Development Level

Tbio 5 | 10,625
Tdark 3 | 7,003
Tchem 2 | 1,890

IMPC Phenotype

preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
decreased fasted circulating g... 1 | 49
decreased food intake 1 | 6
decreased grip strength 1 | 123
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged liver 1 | 3
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased fasted circulating g... 1 | 68
increased startle reflex 1 | 38
male infertility 1 | 62

Disease

osteosarcoma 7 | 7,933
ovarian cancer 7 | 8,491
psoriasis 6 | 6,685
medulloblastoma, large-cell 5 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
lung carcinoma 4 | 2,844
Amnestic disorder 3 | 37
Multiple myeloma 3 | 1,327
active Crohn's disease 3 | 918
atypical teratoid / rhabdoid tumor 3 | 4,369
breast carcinoma 3 | 1,614
diabetes mellitus 3 | 1,663
glioblastoma 3 | 5,572
interstitial cystitis 3 | 2,299
invasive ductal carcinoma 3 | 2,950
oligodendroglioma 3 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pilocytic astrocytoma 3 | 3,086
primitive neuroectodermal tumor 3 | 3,031
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 2,087
Alzheimer's disease 2 | 644
Amnesia 2 | 17
Anxiety Disorders 2 | 37
Atopic dermatitis 2 | 944
Autistic Disorder 2 | 320
Breast cancer 2 | 3,098
Diabetes insipidus 2 | 14
Diarrhea 2 | 155
Duchenne muscular dystrophy 2 | 602
Dysmenorrhea 2 | 19
Hypertension 2 | 293
Hypertensive disease 2 | 193
Hypoglycemia 2 | 81
Hyponatremia 2 | 6
Hypotension 2 | 53
Ischemia 2 | 27
Liver Cirrhosis 2 | 101
Neurohypophyseal diabetes insipidus 2 | 13
Obesity 2 | 616
Pain 2 | 70
Pituitary hypoplasia 2 | 15
Polyuria 2 | 6
Schizophrenia 2 | 503
Seizures 2 | 95
astrocytoma 2 | 1,493
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
dermatomyositis 2 | 966
ependymoma 2 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
juvenile dermatomyositis 2 | 1,189
lung cancer 2 | 4,473
non primary Sjogren syndrome sicca 2 | 840
pediatric high grade glioma 2 | 2,712
sonic hedgehog group medulloblastoma 2 | 1,482
Alcohol dependence 1 | 107
Amenorrhea 1 | 60
Angina pectoris 1 | 21
Anorexia nervosa 1 | 59
Asperger syndrome 1 | 35
Bilirubin metabolic disorder 1 | 39
Brain disease 1 | 84
Bulimia nervosa 1 | 15
Cardiac arrhythmia 1 | 26
Celiac disease 1 | 112
Cystinuria 1 | 18
Ectopic pregnancy 1 | 16
Edema 1 | 38
Endometritis 1 | 21
Gas gangrene 1 | 15
Gestational trophoblastic neoplasm 1 | 15
Heart failure 1 | 80
Hepatitis 1 | 61
Hyperactive behavior 1 | 31
Hypercalcemia 1 | 37
Hypoactive sexual desire disorder 1 | 9
Hypokalemia 1 | 40
Hypopituitarism 1 | 36
Insulin Resistance 1 | 50
Insulinoma 1 | 20
Mammary Neoplasms, Experimental 1 | 149
Mastitis 1 | 48
Memory Disorders 1 | 36
Meniere's disease 1 | 25
Meningitis 1 | 46
Myoma 1 | 12
Neonatal jaundice 1 | 15
Oligohydramnios 1 | 18
Placenta praevia 1 | 9
Placental insufficiency 1 | 13
Portal hypertension 1 | 21
Prader-Willi syndrome 1 | 45
Psychotic Disorders 1 | 20
Small cell carcinoma of lung 1 | 45
Substance Withdrawal Syndrome 1 | 55
Weight Gain 1 | 87
Weight decreased 1 | 18
chronic kidney disease 1 | 90
fascioscapulohumeral muscular dystrophy 1 | 100

Tissue

Blood and immune system 10 | 17,994
Cardiovascular System 10 | 17,957
Digestive Tract 10 | 18,472
Endocrine System 10 | 18,511
Female tissues 10 | 18,646
Liver and Pancreas 10 | 18,135
Nervous System 10 | 18,560
Respiratory system 10 | 17,483
Skin and soft tissues 10 | 18,114
Urinary Tract 10 | 18,443
Male tissues 9 | 17,968

Target Family

Enzyme 8 | 4,146
Non-IDG 2 | 11,969

PathwayCommons: panther Pathway

Vasopressin synthesis 10 | 10
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 81 | 81
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carboxypeptidase E CPE Tbio Enzyme -2.99888 983.1 216
Vasopressin-neurophysin 2-copeptin AVP Tbio Non-IDG -3.91847 8071.2 168
Oxytocin-neurophysin 1 OXT Tbio Non-IDG -4.17412 14677.4 133
Signal peptidase complex catalytic subunit SEC11C SEC11C Tdark Enzyme -0.46982 3.55 21
Prolyl endopeptidase PREP Tchem Enzyme -2.48589 335.2 140
Prolyl endopeptidase-like PREPL Tbio Enzyme -1.43419 29.8 80
Signal peptidase complex subunit 2 SPCS2 Tdark Enzyme -0.26503 1.68 37
Signal peptidase complex subunit 3 SPCS3 Tdark Enzyme -0.52720 3.96 39
Peptidyl-glycine alpha-amidating monooxygenase PAM Tchem Enzyme -2.59205 375.9 75
Signal peptidase complex catalytic subunit SEC11A SEC11A Tbio Enzyme -0.76426 10.1 94