Development Level

Tbio 22 | 10,625
Tclin 16 | 602
Tchem 15 | 1,890
Tdark 1 | 7,003

Collection

Ion Channel: IDG Consortium (Targets) 2 | 102
Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

abnormal behavior 2 | 226
decreased fasted circulating g... 2 | 49
hyperactivity 2 | 108
straub tail 2 | 26
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
cataract 1 | 26
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating insulin ... 1 | 75
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased gamma-delta T cell n... 1 | 18
decreased granulocyte number 1 | 8
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased late germinal center... 1 | 2
decreased lean body mass 1 | 195
decreased monocyte cell number 1 | 28
decreased myeloid cell number ... 1 | 1
decreased pre-pro B cell numbe... 1 | 2
decreased pro-B cell number 1 | 2
decreased total body fat amoun... 1 | 186
enlarged epididymis 1 | 27
enlarged heart 1 | 111
impaired pupillary reflex 1 | 14
increased B cell number 1 | 23
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating chloride... 1 | 43
increased circulating iron lev... 1 | 25
increased circulating sodium l... 1 | 71
increased early germinal cente... 1 | 2
increased heart weight 1 | 37
increased immature B cell numb... 1 | 1
increased lean body mass 1 | 107
increased mature B cell number 1 | 12
increased or absent threshold ... 1 | 128
increased pre-B cell number 1 | 1
increased startle reflex 1 | 38
limb grasping 1 | 35
mydriasis 1 | 9
persistence of hyaloid vascula... 1 | 22
preweaning lethality, incomple... 1 | 260
shortened RR interval 1 | 19
thrombocytopenia 1 | 46

Disease

medulloblastoma, large-cell 37 | 6,234
glioblastoma 35 | 5,572
atypical teratoid / rhabdoid tumor 30 | 4,369
oligodendroglioma 30 | 2,849
Schizophrenia 26 | 503
pilocytic astrocytoma 26 | 3,086
pediatric high grade glioma 25 | 2,712
primitive neuroectodermal tumor 24 | 3,031
psoriasis 24 | 6,685
osteosarcoma 22 | 7,933
Carcinoma 21 | 2,147
Epilepsy 21 | 346
ovarian cancer 20 | 8,491
Pick disease 18 | 1,893
lung carcinoma 18 | 2,844
astrocytic glioma 17 | 2,241
subependymal giant cell astrocytoma 17 | 2,287
ependymoma 16 | 2,514
group 4 medulloblastoma 15 | 1,875
Parkinson's disease 14 | 364
astrocytoma 14 | 1,493
Toxic encephalopathy 12 | 131
lung cancer 12 | 4,473
posterior fossa group A ependymoma 12 | 1,511
Lennox-Gastaut syndrome 11 | 34
Simple partial seizure 11 | 26
group 3 medulloblastoma 11 | 2,254
Bipolar Disorder 10 | 266
General anesthesia 10 | 53
Local anesthesia 10 | 40
adult high grade glioma 10 | 2,148
malignant mesothelioma 10 | 3,163
Alzheimer's disease 9 | 644
Autistic Disorder 9 | 320
Epilepsy characterized by intractable complex partial seizures 9 | 28
Intellectual disability 9 | 573
Migraine Prevention 9 | 22
Tonic-clonic epilepsy 9 | 47
Amyotrophic Lateral Sclerosis 8 | 432
medulloblastoma 8 | 1,524
pituitary cancer 8 | 1,972
posterior fossa group B ependymoma 8 | 1,530
Alcohol dependence 7 | 107
Major Depressive Disorder 7 | 106
atypical teratoid/rhabdoid tumor 7 | 1,095
non primary Sjogren syndrome sicca 7 | 840
sonic hedgehog group medulloblastoma 7 | 1,482
Alcoholism 6 | 14
Arteriosclerotic Parkinsonism 6 | 8
Attention deficit hyperactivity disorder 6 | 156
Breast cancer 6 | 3,098
Carney complex 6 | 23
Extrapyramidal disease 6 | 8
Influenza A Prevention 6 | 7
Influenza due to Influenza A virus 6 | 7
Neurodegenerative disease 6 | 383
Parkinsonism 6 | 19
Postencephalitic parkinsonism 6 | 12
Tetanus 6 | 66
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
lung adenocarcinoma 6 | 2,714
pancreatic cancer 6 | 2,300
Cocaine-Related Disorders 5 | 88
Down syndrome 5 | 548
Huntington's disease 5 | 72
Waldenstrons macroglobulinemia 5 | 764
acute quadriplegic myopathy 5 | 1,157
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
invasive ductal carcinoma 5 | 2,950
primary pancreatic ductal adenocarcinoma 5 | 1,271
Duchenne muscular dystrophy 4 | 602
Epilepsy, Temporal Lobe 4 | 23
Moderate to Severe Alzheimer's Type Dementia 4 | 5
Multiple myeloma 4 | 1,327
Partial seizure 4 | 15
Primary pigmented nodular adrenocortical disease 4 | 13
Rheumatoid Arthritis 4 | 1,170
Substance Withdrawal Syndrome 4 | 55
Substance-Related Disorders 4 | 114
colon cancer 4 | 1,475
cystic fibrosis 4 | 1,670
ductal carcinoma in situ 4 | 1,745
gastric carcinoma 4 | 832
ulcerative colitis 4 | 2,087
Brain Ischemia 3 | 87
Cerebrovascular disease 3 | 231
Morphine dependence 3 | 19
Pain agnosia 3 | 99
Seizures 3 | 95
Status Epilepticus 3 | 85
Vascular disease 3 | 281
adrenocortical carcinoma 3 | 1,427
breast carcinoma 3 | 1,614
cutaneous lupus erythematosus 3 | 1,056
dermatomyositis 3 | 966
interstitial cystitis 3 | 2,299
juvenile dermatomyositis 3 | 1,189
pancreatic carcinoma 3 | 567
tuberculosis 3 | 1,563

Tissue

Blood and immune system 54 | 17,994
Cardiovascular System 54 | 17,957
Digestive Tract 54 | 18,472
Endocrine System 54 | 18,511
Female tissues 54 | 18,646
Liver and Pancreas 54 | 18,135
Male tissues 54 | 17,968
Nervous System 54 | 18,560
Respiratory system 54 | 17,483
Skin and soft tissues 54 | 18,114
Urinary Tract 54 | 18,443

Target Family

Ion Channel 19 | 341
Non-IDG 14 | 11,969
GPCR 6 | 408
Transporter 6 | 473
Enzyme 5 | 4,146
Kinase 4 | 634

PathwayCommons: panther Pathway

Metabotropic glutamate recepto... 54 | 54
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 81 | 81
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 10 ADCY10 Tchem Enzyme -3.12717 1279.3 98
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.50812 310.3 171
Guanine nucleotide-binding protein G(i) subunit alpha-1 GNAI1 Tchem Non-IDG -0.58441 3.11 173
Guanine nucleotide-binding protein G(i) subunit alpha-2 GNAI2 Tbio Non-IDG -1.25323 16.6 188
Glutamate receptor 2 GRIA2 Tclin Ion Channel -2.63267 422.3 407
Glutamate receptor 1 GRIA1 Tclin Ion Channel -3.15085 1376.5 691
Glutamate receptor 3 GRIA3 Tclin Ion Channel -1.95421 83.7 203
Glutamate receptor ionotropic, kainate 2 GRIK2 Tclin Ion Channel -2.42011 265.6 219
Glutamate receptor ionotropic, kainate 3 GRIK3 Tclin Ion Channel -1.48916 28.2 125
Vesicle-associated membrane protein 1 VAMP1 Tbio Non-IDG -1.73811 49.5 212