Development Level

Tclin 15 | 602
Tbio 14 | 10,625
Tchem 12 | 1,890
Tdark 1 | 7,003

Collection

Ion Channel: IDG Consortium (Targets) 2 | 102

IMPC Phenotype

abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal retinal pigmentation 1 | 61
decreased body weight 1 | 174
decreased circulating HDL chol... 1 | 77
decreased circulating alanine ... 1 | 53
decreased circulating chloride... 1 | 32
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased gamma-delta T cell n... 1 | 18
decreased granulocyte number 1 | 8
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased late germinal center... 1 | 2
decreased lean body mass 1 | 195
decreased monocyte cell number 1 | 28
decreased myeloid cell number ... 1 | 1
decreased pre-pro B cell numbe... 1 | 2
decreased pro-B cell number 1 | 2
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
increased B cell number 1 | 23
increased T cell number 1 | 15
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased early germinal cente... 1 | 2
increased immature B cell numb... 1 | 1
increased lean body mass 1 | 107
increased mature B cell number 1 | 12
increased pre-B cell number 1 | 1
increased startle reflex 1 | 38
persistence of hyaloid vascula... 1 | 22
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
straub tail 1 | 26
thrombocytopenia 1 | 46

Disease

glioblastoma 31 | 5,572
medulloblastoma, large-cell 29 | 6,234
Schizophrenia 28 | 503
atypical teratoid / rhabdoid tumor 26 | 4,369
pilocytic astrocytoma 26 | 3,086
pediatric high grade glioma 22 | 2,712
primitive neuroectodermal tumor 22 | 3,031
oligodendroglioma 21 | 2,849
lung carcinoma 18 | 2,844
osteosarcoma 18 | 7,933
psoriasis 18 | 6,685
astrocytic glioma 17 | 2,241
ependymoma 17 | 2,514
Epilepsy 16 | 346
ovarian cancer 16 | 8,491
Carcinoma 15 | 2,147
subependymal giant cell astrocytoma 14 | 2,287
Parkinson's disease 13 | 364
Bipolar Disorder 12 | 266
Lennox-Gastaut syndrome 11 | 34
Pick disease 11 | 1,893
Simple partial seizure 11 | 26
General anesthesia 10 | 53
Local anesthesia 10 | 40
Toxic encephalopathy 10 | 131
group 4 medulloblastoma 10 | 1,875
posterior fossa group A ependymoma 10 | 1,511
Epilepsy characterized by intractable complex partial seizures 9 | 28
Intellectual disability 9 | 573
Migraine Prevention 9 | 22
Tonic-clonic epilepsy 9 | 47
adult high grade glioma 8 | 2,148
malignant mesothelioma 8 | 3,163
Alzheimer's disease 7 | 644
Amyotrophic Lateral Sclerosis 7 | 432
Autistic Disorder 7 | 320
Tetanus 7 | 66
astrocytoma 7 | 1,493
lung cancer 7 | 4,473
medulloblastoma 7 | 1,524
Alcoholism 6 | 14
Arteriosclerotic Parkinsonism 6 | 8
Cocaine-Related Disorders 6 | 88
Extrapyramidal disease 6 | 8
Influenza A Prevention 6 | 7
Influenza due to Influenza A virus 6 | 7
Parkinsonism 6 | 19
Postencephalitic parkinsonism 6 | 12
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
non primary Sjogren syndrome sicca 6 | 840
pituitary cancer 6 | 1,972
sonic hedgehog group medulloblastoma 6 | 1,482
Major Depressive Disorder 5 | 106
atypical teratoid/rhabdoid tumor 5 | 1,095
group 3 medulloblastoma 5 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
invasive ductal carcinoma 5 | 2,950
lung adenocarcinoma 5 | 2,714
Alcohol dependence 4 | 107
Botulism 4 | 20
Down syndrome 4 | 548
Huntington's disease 4 | 72
Moderate to Severe Alzheimer's Type Dementia 4 | 5
Partial seizure 4 | 15
cystic fibrosis 4 | 1,670
ductal carcinoma in situ 4 | 1,745
pancreatic cancer 4 | 2,300
posterior fossa group B ependymoma 4 | 1,530
Brain Ischemia 3 | 87
Cerebrovascular disease 3 | 231
Epilepsy, Temporal Lobe 3 | 23
Gaucher disease type 1 3 | 171
Morphine dependence 3 | 19
Multiple myeloma 3 | 1,327
Neurodegenerative disease 3 | 383
Psychoses, Substance-Induced 3 | 17
Psychosexual Disorders 3 | 6
Rheumatoid Arthritis 3 | 1,170
Substance Withdrawal Syndrome 3 | 55
Vascular disease 3 | 281
acute quadriplegic myopathy 3 | 1,157
adrenocortical carcinoma 3 | 1,427
chronic lymphocytic leukemia 3 | 244
fibroadenoma 3 | 557
gastric carcinoma 3 | 832
interstitial cystitis 3 | 2,299
juvenile dermatomyositis 3 | 1,189
non-small cell lung carcinoma 3 | 413
obsessive-compulsive disorder 3 | 34
primary pancreatic ductal adenocarcinoma 3 | 1,271
Atopic dermatitis 2 | 944
Attention deficit hyperactivity disorder 2 | 156
Breast cancer 2 | 3,098
Endometriosis 2 | 535
Myocardial Ischemia 2 | 169
Waldenstrons macroglobulinemia 2 | 764
breast carcinoma 2 | 1,614
dermatomyositis 2 | 966
pancreatic carcinoma 2 | 567

Tissue

Digestive Tract 42 | 18,472
Endocrine System 42 | 18,511
Female tissues 42 | 18,646
Liver and Pancreas 42 | 18,135
Nervous System 42 | 18,560
Blood and immune system 41 | 17,994
Cardiovascular System 41 | 17,957
Urinary Tract 41 | 18,443
Male tissues 40 | 17,968
Skin and soft tissues 40 | 18,114
Respiratory system 38 | 17,483

Target Family

Ion Channel 17 | 341
Non-IDG 12 | 11,969
Transporter 7 | 473
Kinase 3 | 634
GPCR 2 | 408
Enzyme 1 | 4,146

PathwayCommons: panther Pathway

Ionotropic glutamate receptor ... 42 | 42
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 81 | 81
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SH3 and multiple ankyrin repeat domains protein 1 SHANK1 Tbio Non-IDG -1.52802 34.3 167
SH3 and multiple ankyrin repeat domains protein 3 SHANK3 Tbio Non-IDG -2.21170 158.8 0
Vesicular glutamate transporter 3 SLC17A8 Tbio Transporter -1.98538 103.1 38
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.50812 310.3 171
Glutamate receptor 2 GRIA2 Tclin Ion Channel -2.63267 422.3 407
Glutamate receptor 1 GRIA1 Tclin Ion Channel -3.15085 1376.5 691
Glutamate receptor 3 GRIA3 Tclin Ion Channel -1.95421 83.7 203
Voltage-dependent calcium channel gamma-5 subunit CACNG5 Tchem Ion Channel 0.09 1.00 57
Metabotropic glutamate receptor 2 GRM2 Tchem GPCR -2.74553 574.9 269
PRKCA-binding protein PICK1 Tbio Non-IDG -2.11607 148.6 326