Development Level

Tbio 88 | 10,625
Tchem 50 | 1,890
Tclin 13 | 602
Tdark 5 | 7,003

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 9 | 633
decreased body weight 5 | 174
abnormal behavior 4 | 226
decreased total body fat amoun... 4 | 186
abnormal embryo size 3 | 112
abnormal femur morphology 3 | 14
abnormal lens morphology 3 | 73
abnormal retina morphology 3 | 100
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 121
embryonic lethality prior to t... 3 | 187
impaired glucose tolerance 3 | 52
increased mean corpuscular hem... 3 | 93
preweaning lethality, incomple... 3 | 260
abnormal coat-hair pigmentatio... 2 | 54
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
decreased circulating creatini... 2 | 31
decreased circulating fructosa... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
decreased lean body mass 2 | 195
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased mature B cell number 2 | 25
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
hyperactivity 2 | 108
increased bone mineral density 2 | 52
increased hematocrit 2 | 36
increased leukocyte cell numbe... 2 | 37
persistence of hyaloid vascula... 2 | 22
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal ear morphology 1 | 5
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal iris morphology 1 | 12
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal pelvic girdle bone mo... 1 | 11
abnormal pericardium morpholog... 1 | 11
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal spinal cord morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal tooth morphology 1 | 24
absent heartbeat 1 | 6
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
decreased CD4-positive, CD25-p... 1 | 24
decreased NK T cell number 1 | 28
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased cervical vertebrae n... 1 | 12
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating iron lev... 1 | 25
decreased fasted circulating g... 1 | 49
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
dilated heart left ventricle 1 | 10
enlarged lymph nodes 1 | 27
improved glucose tolerance 1 | 56
increased NK T cell number 1 | 11
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased or absent threshold ... 1 | 128
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased vertical activity 1 | 18
irregularly shaped pupil 1 | 7
polycystic kidney 1 | 9
polydactyly 1 | 22
short tibia 1 | 82
thrombocytopenia 1 | 46
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 110 | 8,491
glioblastoma 86 | 5,572
osteosarcoma 83 | 7,933
lung cancer 70 | 4,473
psoriasis 69 | 6,685
medulloblastoma, large-cell 64 | 6,234
Carcinoma 63 | 2,147
pilocytic astrocytoma 63 | 3,086
pancreatic cancer 62 | 2,300
Cancer 60 | 2,346
atypical teratoid / rhabdoid tumor 59 | 4,369
primary pancreatic ductal adenocarcinoma 53 | 1,271
Breast cancer 52 | 3,098
pediatric high grade glioma 51 | 2,712
invasive ductal carcinoma 50 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,956
lung carcinoma 42 | 2,844
malignant mesothelioma 42 | 3,163
ulcerative colitis 42 | 2,087
lung adenocarcinoma 41 | 2,714
non-small cell lung cancer 41 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,988
subependymal giant cell astrocytoma 38 | 2,287
interstitial cystitis 37 | 2,299
oligodendroglioma 37 | 2,849
primitive neuroectodermal tumor 35 | 3,031
cystic fibrosis 33 | 1,670
juvenile dermatomyositis 33 | 1,189
posterior fossa group A ependymoma 32 | 1,511
ependymoma 31 | 2,514
astrocytoma 30 | 1,493
Duchenne muscular dystrophy 29 | 602
breast carcinoma 29 | 1,614
gastric carcinoma 29 | 832
pituitary cancer 27 | 1,972
diabetes mellitus 26 | 1,663
ductal carcinoma in situ 26 | 1,745
tuberculosis 26 | 1,563
group 4 medulloblastoma 25 | 1,875
sonic hedgehog group medulloblastoma 24 | 1,482
Pick disease 23 | 1,893
astrocytic glioma 23 | 2,241
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 499
nasopharyngeal carcinoma 23 | 1,056
dermatomyositis 22 | 966
colon cancer 20 | 1,475
primary Sjogren syndrome 20 | 788
Multiple myeloma 19 | 1,327
acute quadriplegic myopathy 18 | 1,157
cutaneous lupus erythematosus 18 | 1,056
group 3 medulloblastoma 18 | 2,254
adult high grade glioma 17 | 2,148
Becker muscular dystrophy 16 | 187
Kidney disease 16 | 397
medulloblastoma 16 | 1,524
urothelial carcinoma 16 | 318
Rheumatoid Arthritis 15 | 1,170
adrenocortical carcinoma 15 | 1,427
esophageal adenocarcinoma 14 | 737
Spontaneous abortion 13 | 108
acute myeloid leukemia 13 | 785
fibroadenoma 12 | 557
interstitial lung disease 12 | 292
non-small cell lung carcinoma 12 | 413
Intellectual disability 11 | 573
Neoplasm Invasiveness 11 | 127
Vascular disease 11 | 281
Waldenstrons macroglobulinemia 11 | 764
active Crohn's disease 11 | 918
limb girdle muscular dystrophy 2A 11 | 156
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
Down syndrome 10 | 548
Heart disease 10 | 279
glioblastoma multiforme 10 | 347
pterygium 10 | 74
spina bifida 10 | 1,064
Alzheimer's disease 9 | 644
Atopic dermatitis 9 | 944
Myopia 9 | 99
Noonan Syndrome 9 | 33
Osteoporosis 9 | 259
Schizophrenia 9 | 503
Stomach Neoplasms 9 | 282
active ulcerative colitis 9 | 477
atypical teratoid/rhabdoid tumor 9 | 1,095
head and neck cancer 9 | 270
head and neck cancer and chronic obstructive pulmonary disease 9 | 237
pancreatic carcinoma 9 | 567
Animal Mammary Neoplasms 8 | 135
Arthritis 8 | 248
Ehlers-Danlos syndrome 8 | 42
Gaucher disease type 1 8 | 171
IGA Glomerulonephritis 8 | 454
Mammary Neoplasms 8 | 410
Mammary Neoplasms, Experimental 8 | 149
Melanoma 8 | 261
Multiple Sclerosis 8 | 498
Osteoarthritis 8 | 96
posterior fossa group B ependymoma 8 | 1,530

Tissue

Blood and immune system 156 | 17,994
Cardiovascular System 156 | 17,957
Digestive Tract 156 | 18,472
Endocrine System 156 | 18,511
Female tissues 156 | 18,646
Liver and Pancreas 156 | 18,135
Male tissues 156 | 17,968
Nervous System 156 | 18,560
Respiratory system 156 | 17,483
Skin and soft tissues 156 | 18,114
Urinary Tract 156 | 18,443

Target Family

Non-IDG 105 | 11,969
Kinase 26 | 634
Enzyme 25 | 4,146

PathwayCommons: panther Pathway

Integrin signalling pathway 156 | 156
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 81 | 81
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
ADP-ribosylation factor-like protein 1 ARL1 Tbio Enzyme -0.40932 3.58 187
Collagen alpha-1(VIII) chain COL8A1 Tbio Non-IDG -1.25305 16.3 98
Collagen alpha-1(I) chain COL1A1 Tbio Non-IDG -2.94271 807.7 451
Collagen alpha-1(IV) chain COL4A1 Tchem Non-IDG -2.25341 170.3 323
Collagen alpha-1(III) chain COL3A1 Tchem Non-IDG -2.54818 328.8 384
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.27384 181.6 339
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
GTPase NRas NRAS Tchem Enzyme -2.98048 880.4 265
Collagen alpha-1(II) chain COL2A1 Tbio Non-IDG -2.86562 689.3 377