Development Level

Tbio 59 | 10,625
Tchem 25 | 1,890
Tclin 20 | 602
Tdark 9 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 5 | 633
decreased body weight 4 | 174
decreased circulating choleste... 4 | 85
decreased lean body mass 4 | 195
decreased bone mineral content 3 | 157
decreased total body fat amoun... 3 | 186
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
preweaning lethality, incomple... 3 | 260
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal respiratory quotient 2 | 9
abnormal rib morphology 2 | 28
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating fructosa... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased lumbar vertebrae num... 2 | 62
embryonic lethality prior to t... 2 | 187
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating chloride... 2 | 43
increased sacral vertebrae num... 2 | 62
tremors 2 | 34
abnormal behavior 1 | 226
abnormal embryo size 1 | 112
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
absent pinna reflex 1 | 21
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating alanine ... 1 | 53
decreased circulating creatini... 1 | 31
decreased circulating phosphat... 1 | 15
decreased circulating potassiu... 1 | 17
decreased effector memory CD4-... 1 | 6
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased heart weight 1 | 44
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
enlarged heart 1 | 111
fusion of vertebral arches 1 | 7
hypoactivity 1 | 89
immune system phenotype 1 | 17
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased erythrocyte cell num... 1 | 26
increased lean body mass 1 | 107
increased monocyte cell number 1 | 27
increased or absent threshold ... 1 | 128
increased red blood cell distr... 1 | 21
increased startle reflex 1 | 38
persistence of hyaloid vascula... 1 | 22
thrombocytopenia 1 | 46
thrombocytosis 1 | 23
vertebral fusion 1 | 23

Disease

ovarian cancer 66 | 8,484
osteosarcoma 54 | 7,933
glioblastoma 47 | 5,572
psoriasis 47 | 6,685
medulloblastoma, large-cell 44 | 6,234
atypical teratoid / rhabdoid tumor 35 | 4,369
pilocytic astrocytoma 30 | 3,086
Cancer 29 | 2,346
lung cancer 29 | 4,466
malignant mesothelioma 28 | 3,162
oligodendroglioma 27 | 2,849
Breast cancer 26 | 3,094
pediatric high grade glioma 26 | 2,712
primitive neuroectodermal tumor 25 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,289
subependymal giant cell astrocytoma 24 | 2,287
ependymoma 23 | 2,514
pancreatic cancer 23 | 2,300
Carcinoma 22 | 2,147
astrocytic glioma 22 | 2,241
diabetes mellitus 21 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
non-small cell lung cancer 21 | 2,798
Pick disease 19 | 1,893
Schizophrenia 19 | 501
astrocytoma 19 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
lung adenocarcinoma 17 | 2,713
lung carcinoma 17 | 2,844
primary pancreatic ductal adenocarcinoma 17 | 1,271
Multiple myeloma 16 | 1,327
Parkinson's disease 16 | 364
adult high grade glioma 16 | 2,148
posterior fossa group B ependymoma 16 | 1,530
Toxic encephalopathy 15 | 131
acute quadriplegic myopathy 15 | 1,157
breast carcinoma 15 | 1,614
juvenile dermatomyositis 15 | 1,189
medulloblastoma 15 | 1,524
Huntington's disease 14 | 72
group 4 medulloblastoma 14 | 1,875
pituitary cancer 14 | 1,972
colon cancer 13 | 1,475
invasive ductal carcinoma 13 | 2,950
Alzheimer's disease 12 | 644
Amyotrophic Lateral Sclerosis 12 | 431
Epilepsy 12 | 346
Intellectual disability 12 | 573
posterior fossa group A ependymoma 12 | 1,511
Neurodegenerative disease 11 | 383
Rheumatoid Arthritis 11 | 1,160
Waldenstrons macroglobulinemia 11 | 765
nasopharyngeal carcinoma 11 | 1,056
Bipolar Disorder 10 | 266
Duchenne muscular dystrophy 10 | 602
Vascular disease 10 | 281
cystic fibrosis 10 | 1,665
group 3 medulloblastoma 10 | 2,254
non primary Sjogren syndrome sicca 10 | 840
sonic hedgehog group medulloblastoma 10 | 1,482
spina bifida 10 | 1,064
ulcerative colitis 10 | 2,087
Acute lymphoid leukemia 9 | 25
Anaplastic large T-cell systemic malignant lymphoma 9 | 10
Burkitt's lymphoma 9 | 15
Carcinoma of breast 9 | 11
Carcinoma of female breast 9 | 20
Diffuse non-Hodgkin's lymphoma, large cell 9 | 12
Follicular non-Hodgkin's lymphoma 9 | 17
Gestational trophoblastic neoplasia 9 | 14
HER2-positive carcinoma of breast 9 | 10
Hodgkin's disease 9 | 18
Hypertensive disorder 9 | 58
Kaposi's sarcoma 9 | 20
Langerhans cell histiocytosis, disseminated 9 | 10
Liposarcoma 9 | 20
Malignant tumor of head and/or neck 9 | 15
Malignant tumor of ovary 9 | 25
Malignant tumor of prostate 9 | 11
Malignant tumor of stomach 9 | 12
Malignant tumor of testis 9 | 11
Mammary Neoplasms 9 | 410
Metastatic Breast Carcinoma 9 | 21
Metastatic Prostate Carcinoma 9 | 18
Mycosis fungoides 9 | 28
Nephroblastoma 9 | 45
Neuroblastoma 9 | 78
Non-Hodgkin's lymphoma 9 | 22
Ocular hypertension 9 | 27
Open-angle glaucoma 9 | 26
Rhabdomyosarcoma 9 | 29
Secondary malignant neoplasm of pancreas 9 | 10
Transitional cell carcinoma 9 | 18
adrenocortical carcinoma 9 | 1,427
atypical teratoid/rhabdoid tumor 9 | 1,095
interstitial cystitis 9 | 2,299
Brain Ischemia 8 | 87
Cerebrovascular disease 8 | 231
acute myeloid leukemia 8 | 780
ductal carcinoma in situ 8 | 1,745

Tissue

Blood and immune system 113 | 17,995
Cardiovascular System 113 | 17,958
Digestive Tract 113 | 18,473
Endocrine System 113 | 18,512
Female tissues 113 | 18,647
Liver and Pancreas 113 | 18,136
Male tissues 113 | 17,969
Nervous System 113 | 18,561
Respiratory system 113 | 17,484
Urinary Tract 113 | 18,444
Skin and soft tissues 112 | 18,115

Target Family

Non-IDG 66 | 11,971
Enzyme 20 | 4,146
Ion Channel 11 | 341
Kinase 8 | 634
Transcription Factor 6 | 1,400
Epigenetic 2 | 242

PathwayCommons: panther Pathway

Huntington disease 113 | 113
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 82 | 82
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.65303 525.6 142
Tubulin beta-2A chain TUBB2A Tclin Non-IDG -1.58651 36.1 215
Calpain-5 CAPN5 Tbio Non-IDG -1.66912 47.3 128
Beta-actin-like protein 2 ACTBL2 Tdark Non-IDG -0.50618 4.39 46
Huntingtin-interacting protein 1-related protein HIP1R Tbio Non-IDG -1.51948 37.8 178
Actin-related protein 2/3 complex subunit 5 ARPC5 Tbio Non-IDG -1.07398 11.5 63
Calpain-12 CAPN12 Tdark Non-IDG -0.42344 3.13 67
Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 Tbio Non-IDG -1.59494 38.2 10