Development Level

Tbio 7 | 10,625
Tchem 3 | 1,890

IMPC Term

abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lung morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal spinal cord morpholog... 1 | 8
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
preweaning lethality, complete... 1 | 633

Disease

osteosarcoma 8 | 7,933
Porphyria 6 | 9
Hereditary coproporphyria 5 | 9
Variegate porphyria 5 | 10
lung cancer 5 | 4,473
ovarian cancer 5 | 8,492
Acute intermittent porphyria 4 | 14
Porphyria cutanea tarda 4 | 12
malignant mesothelioma 4 | 3,163
medulloblastoma, large-cell 4 | 6,234
psoriasis 4 | 6,685
Erythropoietic protoporphyria 3 | 15
glioblastoma 3 | 5,572
oligodendroglioma 3 | 2,849
Anemia 2 | 252
Cancer 2 | 2,346
Cutaneous porphyria 2 | 6
Epilepsy 2 | 346
Microcephaly 2 | 149
Multiple myeloma 2 | 1,328
Prostatic Neoplasms 2 | 471
Toxic encephalopathy 2 | 131
Waldenstrons macroglobulinemia 2 | 765
astrocytic glioma 2 | 2,241
astrocytoma 2 | 1,493
atypical teratoid / rhabdoid tumor 2 | 4,369
atypical teratoid/rhabdoid tumor 2 | 1,095
cutaneous lupus erythematosus 2 | 1,056
ependymoma 2 | 2,514
group 3 medulloblastoma 2 | 2,254
invasive ductal carcinoma 2 | 2,950
lung adenocarcinoma 2 | 2,714
non-small cell lung cancer 2 | 2,798
pancreatic cancer 2 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
primitive neuroectodermal tumor 2 | 3,031
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis 2 | 1,563
Angelman syndrome 1 | 38
Cerebral palsy 1 | 28
Cerebrovascular disease 1 | 231
Clubfoot 1 | 35
Congenital myasthenic syndrome, acetazolamide-responsive 1 | 5
Coproporphyria 1 | 1
Cytochrome-c Oxidase Deficiency 1 | 15
Dermatitis 1 | 141
Encephalitis 1 | 54
Endogenous depression 1 | 4
Endophthalmitis 1 | 10
Fatal infantile encephalocardiomyopathy 1 | 3
Fibrosis 1 | 40
Friedreich ataxia 1 | 23
Gaucher disease type 1 1 | 171
Harderoporphyria 1 | 1
Head and Neck Neoplasms 1 | 23
Hematological Disease 1 | 8
Hemochromatosis 1 | 55
Histidinemia 1 | 9
Hypertensive disease 1 | 193
Hypertrichosis 1 | 23
Hypospadias 1 | 65
Inverted follicular keratosis 1 | 3
Kidney Diseases 1 | 86
Lead Poisoning 1 | 6
Leigh disease 1 | 81
Leigh syndrome 1 | 34
Liver disease 1 | 219
Liver diseases 1 | 66
Meningioma 1 | 27
Mitochondrial complex IV deficiency 1 | 6
Myasthenic Syndrome due to Mutation in SCN4A 1 | 5
Neonatal diabetes mellitus 1 | 6
Omphalocele 1 | 22
Patau syndrome 1 | 15
Periventricular leukomalacia 1 | 6
Pleurisy 1 | 18
Polyhydramnios 1 | 29
Porphyria, South African type 1 | 2
Prader-Willi syndrome 1 | 45
Q fever 1 | 11
Renal Cell Carcinoma 1 | 199
Retinal detachment 1 | 33
Seizures 1 | 95
Separation anxiety disorder 1 | 6
Siderosis 1 | 9
Silver-Russell syndrome 1 | 37
Spinal cord disease 1 | 22
Tyrosinemia 1 | 12
adrenocortical carcinoma 1 | 1,427
aldosterone-producing adenoma 1 | 664
cystic fibrosis 1 | 1,670
cytochrome-c oxidase deficiency disease 1 | 19
dermatomyositis 1 | 967
hepatocellular carcinoma 1 | 550
medulloblastoma 1 | 1,524
nasopharyngeal carcinoma 1 | 1,056
pancreatic carcinoma 1 | 567
pituitary cancer 1 | 1,972
sarcoidosis 1 | 368
tuberculosis and treatment for 6 months 1 | 686

Tissue

Blood and immune system 10 | 17,995
Cardiovascular System 10 | 17,958
Digestive Tract 10 | 18,473
Endocrine System 10 | 18,512
Female tissues 10 | 18,647
Liver and Pancreas 10 | 18,136
Male tissues 10 | 17,969
Nervous System 10 | 18,561
Respiratory system 10 | 17,484
Skin and soft tissues 10 | 18,115
Urinary Tract 10 | 18,444

Target Family

Enzyme 10 | 4,146

PathwayCommons: panther Pathway

Heme biosynthesis 10 | 10
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 82 | 82
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protoheme IX farnesyltransferase, mitochondrial COX10 Tbio Enzyme -1.58383 36.7 127
Protoporphyrinogen oxidase PPOX Tchem Enzyme -2.46338 291.0 158
Delta-aminolevulinic acid dehydratase ALAD Tbio Enzyme -3.01264 979.9 141
Probable glutamate--tRNA ligase, mitochondrial EARS2 Tbio Enzyme -2.38552 236.8 52
Ferrochelatase, mitochondrial FECH Tbio Enzyme -2.71654 505.0 124
Glutamine--tRNA ligase QARS Tchem Enzyme -1.61309 39.5 70
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial CPOX Tbio Enzyme -2.03535 108.1 75
Uroporphyrinogen decarboxylase UROD Tbio Enzyme -2.93084 838.2 164
Porphobilinogen deaminase HMBS Tbio Enzyme -2.73938 543.7 180
Bifunctional glutamate/proline--tRNA ligase EPRS Tchem Enzyme -3.09040 1189.8 95