Development Level

Tchem 46 | 1,890
Tbio 42 | 10,625
Tclin 9 | 602
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 10 | 633
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
decreased body weight 4 | 174
decreased bone mineral content 3 | 157
decreased grip strength 3 | 123
decreased kidney weight 3 | 7
enlarged lymph nodes 3 | 27
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
cataract 2 | 26
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating triglyce... 2 | 83
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
impaired pupillary reflex 2 | 14
increased circulating alkaline... 2 | 119
increased erythrocyte cell num... 2 | 26
increased neutrophil cell numb... 2 | 15
male infertility 2 | 62
abnormal behavior 1 | 226
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal heart left ventricle ... 1 | 20
abnormal lens morphology 1 | 73
abnormal motor learning 1 | 4
abnormal respiratory quotient 1 | 9
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal skin morphology 1 | 23
abnormal spinal cord morpholog... 1 | 8
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
absent heartbeat 1 | 6
absent startle reflex 1 | 15
cleft palate 1 | 6
corneal opacity 1 | 25
decreased B cell number 1 | 30
decreased body length 1 | 108
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating free fat... 1 | 39
decreased circulating potassiu... 1 | 17
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
enlarged heart 1 | 111
hydrops fetalis 1 | 22
immune system phenotype 1 | 17
impaired righting response 1 | 19
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
mydriasis 1 | 9
narrow eye opening 1 | 15
no spontaneous movement 1 | 1
small testis 1 | 37
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

ovarian cancer 60 | 8,492
Cancer 54 | 2,346
osteosarcoma 53 | 7,933
medulloblastoma, large-cell 48 | 6,234
glioblastoma 47 | 5,572
lung cancer 43 | 4,473
atypical teratoid / rhabdoid tumor 41 | 4,369
psoriasis 40 | 6,685
ependymoma 29 | 2,514
Carcinoma 26 | 2,147
Breast cancer 25 | 3,099
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
malignant mesothelioma 24 | 3,163
pilocytic astrocytoma 24 | 3,086
primitive neuroectodermal tumor 24 | 3,031
astrocytic glioma 23 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
lung adenocarcinoma 23 | 2,714
oligodendroglioma 23 | 2,849
subependymal giant cell astrocytoma 23 | 2,287
adult high grade glioma 22 | 2,148
invasive ductal carcinoma 22 | 2,950
lung carcinoma 22 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
pediatric high grade glioma 19 | 2,712
non-small cell lung cancer 18 | 2,798
group 3 medulloblastoma 17 | 2,254
interstitial cystitis 17 | 2,299
Pick disease 16 | 1,893
pituitary cancer 16 | 1,972
group 4 medulloblastoma 15 | 1,875
medulloblastoma 14 | 1,524
pancreatic cancer 14 | 2,300
ulcerative colitis 14 | 2,087
Lung Neoplasms 13 | 171
Multiple myeloma 13 | 1,328
Rheumatoid Arthritis 12 | 1,171
colon cancer 12 | 1,475
juvenile dermatomyositis 12 | 1,189
Mammary Neoplasms 11 | 410
Waldenstrons macroglobulinemia 11 | 765
adrenocortical carcinoma 11 | 1,427
astrocytoma 11 | 1,493
breast carcinoma 11 | 1,614
diabetes mellitus 11 | 1,663
ductal carcinoma in situ 11 | 1,745
primary pancreatic ductal adenocarcinoma 11 | 1,271
Intellectual disability 10 | 573
Noonan Syndrome 10 | 33
Vascular disease 10 | 281
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
tuberculosis 10 | 1,563
Cleft Lip 9 | 91
Cleft palate 9 | 125
spina bifida 9 | 1,064
Schizophrenia 8 | 503
cystic fibrosis 8 | 1,670
dermatomyositis 8 | 967
posterior fossa group A ependymoma 8 | 1,511
posterior fossa group B ependymoma 8 | 1,530
tuberculosis and treatment for 6 months 8 | 686
Achondroplasia 7 | 20
Cardiomyopathies 7 | 90
Costello Syndrome 7 | 18
Craniosynostosis 7 | 47
Heart disease 7 | 279
LADD syndrome 7 | 9
LEOPARD Syndrome 7 | 20
Melanoma 7 | 261
Prostatic Neoplasms 7 | 471
Squamous cell carcinoma 7 | 96
Stomach Neoplasms 7 | 282
atypical teratoid/rhabdoid tumor 7 | 1,095
cutaneous lupus erythematosus 7 | 1,056
non-small cell lung carcinoma 7 | 413
primary Sjogren syndrome 7 | 789
Cardiofaciocutaneous syndrome 6 | 15
Colorectal Neoplasms 6 | 217
Liver carcinoma 6 | 217
Neoplasm Metastasis 6 | 138
Parkinson's disease 6 | 364
Renal Cell Carcinoma 6 | 199
chronic lymphocytic leukemia 6 | 244
progressive supranuclear palsy 6 | 674
Acrocephalosyndactylia 5 | 15
Alzheimer's disease 5 | 644
Autistic Disorder 5 | 320
Cardiomegaly 5 | 66
Craniofacial Abnormalities 5 | 147
Down syndrome 5 | 548
Hamman-Rich syndrome 5 | 35
Hyperalgesia 5 | 71
IGA Glomerulonephritis 5 | 454
Mammary Neoplasms, Experimental 5 | 150
Myocardial Ischemia 5 | 169
Neurodegenerative disease 5 | 383
Obesity 5 | 616
acute myeloid leukemia 5 | 785
aldosterone-producing adenoma 5 | 664
nasopharyngeal carcinoma 5 | 1,056

Tissue

Endocrine System 99 | 18,512
Female tissues 99 | 18,647
Male tissues 99 | 17,969
Nervous System 99 | 18,561
Skin and soft tissues 99 | 18,115
Blood and immune system 98 | 17,995
Cardiovascular System 98 | 17,958
Digestive Tract 98 | 18,473
Liver and Pancreas 98 | 18,136
Urinary Tract 98 | 18,444
Respiratory system 95 | 17,484

Target Family

Kinase 42 | 634
Non-IDG 33 | 11,969
Enzyme 24 | 4,146

PathwayCommons: panther Pathway

FGF signaling pathway 99 | 99
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 82 | 82
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

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