Development Level

Tchem 55 | 1,890
Tbio 44 | 10,625
Tclin 8 | 602
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

decreased body weight 4 | 174
preweaning lethality, complete... 4 | 633
enlarged lymph nodes 3 | 27
abnormal bone mineralization 2 | 55
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 53
decreased circulating aspartat... 2 | 27
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
increased circulating alkaline... 2 | 119
increased erythrocyte cell num... 2 | 26
increased lean body mass 2 | 107
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal hair growth 1 | 8
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal spinal cord morpholog... 1 | 8
abnormal testis morphology 1 | 30
absent heartbeat 1 | 6
absent pinna reflex 1 | 21
cataract 1 | 26
decreased B cell number 1 | 30
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating free fat... 1 | 39
decreased lactate dehydrogenas... 1 | 14
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
hydrops fetalis 1 | 22
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased body length 1 | 20
increased body weight 1 | 42
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
male infertility 1 | 62
preweaning lethality, incomple... 1 | 260
rough coat 1 | 1
small testis 1 | 37
sparse hair 1 | 6
thrombocytosis 1 | 23

Disease

ovarian cancer 68 | 8,492
Cancer 63 | 2,346
osteosarcoma 63 | 7,933
medulloblastoma, large-cell 55 | 6,234
glioblastoma 53 | 5,572
lung cancer 48 | 4,473
psoriasis 47 | 6,685
atypical teratoid / rhabdoid tumor 46 | 4,369
Breast cancer 36 | 3,099
lung adenocarcinoma 36 | 2,714
Carcinoma 35 | 2,147
ependymoma 32 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,289
pilocytic astrocytoma 30 | 3,086
interstitial cystitis 28 | 2,299
malignant mesothelioma 28 | 3,163
subependymal giant cell astrocytoma 28 | 2,287
ulcerative colitis 28 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,988
invasive ductal carcinoma 26 | 2,950
lung carcinoma 26 | 2,844
pancreatic cancer 26 | 2,300
pediatric high grade glioma 26 | 2,712
primitive neuroectodermal tumor 26 | 3,031
astrocytic glioma 25 | 2,241
adult high grade glioma 24 | 2,148
non-small cell lung cancer 24 | 2,798
oligodendroglioma 24 | 2,849
group 4 medulloblastoma 21 | 1,875
Rheumatoid Arthritis 20 | 1,171
juvenile dermatomyositis 19 | 1,189
Pick disease 18 | 1,893
pituitary cancer 18 | 1,972
medulloblastoma 17 | 1,524
spina bifida 17 | 1,064
Multiple myeloma 16 | 1,328
group 3 medulloblastoma 16 | 2,254
primary pancreatic ductal adenocarcinoma 16 | 1,271
astrocytoma 15 | 1,493
ductal carcinoma in situ 15 | 1,745
Lung Neoplasms 14 | 171
Mammary Neoplasms 14 | 410
diabetes mellitus 14 | 1,663
Prostatic Neoplasms 13 | 471
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
Noonan Syndrome 12 | 33
Schizophrenia 12 | 503
cutaneous lupus erythematosus 12 | 1,056
posterior fossa group B ependymoma 12 | 1,530
Asthma 11 | 349
Stomach Neoplasms 11 | 282
Vascular disease 11 | 281
Waldenstrons macroglobulinemia 11 | 765
breast carcinoma 11 | 1,614
cystic fibrosis 11 | 1,670
primary Sjogren syndrome 11 | 789
tuberculosis 11 | 1,563
Melanoma 10 | 261
Neoplasm Metastasis 10 | 138
acute quadriplegic myopathy 10 | 1,157
adrenocortical carcinoma 10 | 1,427
colon cancer 10 | 1,475
dermatomyositis 10 | 967
ovarian neoplasm 10 | 97
progressive supranuclear palsy 10 | 674
Cardiomyopathies 9 | 90
Heart disease 9 | 279
Liver carcinoma 9 | 217
Mammary Neoplasms, Experimental 9 | 150
Squamous cell carcinoma 9 | 96
chronic lymphocytic leukemia 9 | 244
nasopharyngeal carcinoma 9 | 1,056
non-small cell lung carcinoma 9 | 413
Animal Mammary Neoplasms 8 | 136
Costello Syndrome 8 | 18
IGA Glomerulonephritis 8 | 454
Intellectual disability 8 | 573
LEOPARD Syndrome 8 | 20
atypical teratoid/rhabdoid tumor 8 | 1,095
hepatocellular carcinoma 8 | 550
pancreatic carcinoma 8 | 567
posterior fossa group A ependymoma 8 | 1,511
tuberculosis and treatment for 6 months 8 | 686
Adenocarcinoma 7 | 115
Alzheimer's disease 7 | 644
Autistic Disorder 7 | 320
Cardiofaciocutaneous syndrome 7 | 15
Colorectal Neoplasms 7 | 217
Neoplasm Invasiveness 7 | 127
Obesity 7 | 616
acute myeloid leukemia 7 | 785
fibroadenoma 7 | 557
gastric carcinoma 7 | 832
mucosa-associated lymphoid tissue lymphoma 7 | 480
sonic hedgehog group medulloblastoma 7 | 1,482
Arthritis 6 | 248
Juvenile arthritis 6 | 124
Myocardial Ischemia 6 | 169
aldosterone-producing adenoma 6 | 664

Tissue

Blood and immune system 109 | 17,995
Cardiovascular System 109 | 17,958
Digestive Tract 109 | 18,473
Endocrine System 109 | 18,512
Female tissues 109 | 18,647
Liver and Pancreas 109 | 18,136
Male tissues 109 | 17,969
Nervous System 109 | 18,561
Respiratory system 109 | 17,484
Skin and soft tissues 109 | 18,115
Urinary Tract 109 | 18,444

Target Family

Kinase 44 | 634
Non-IDG 33 | 11,969
Enzyme 25 | 4,146
Transcription Factor 7 | 1,400

PathwayCommons: panther Pathway

EGF receptor signaling pathway 109 | 109
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 82 | 82
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 3 MAP3K3 Tchem Kinase -1.70303 53.0 162
Protein kinase C beta type PRKCB Tchem Kinase -1.97915 83.5 530
Mitogen-activated protein kinase kinase kinase 5 MAP3K5 Tchem Kinase -2.61089 467.7 1104
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.51668 46.0 252
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.45286 25.5 179
Ras-related C3 botulinum toxin substrate 2 RAC2 Tchem Enzyme -2.87547 633.7 216
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.04744 808.6 1868
Signal transducer and activator of transcription 4 STAT4 Tbio Transcription Factor -2.48798 302.9 704
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.64445 3.33 246
Protein sprouty homolog 1 SPRY1 Tbio Non-IDG -2.16395 131.0 148