Development Level

Tbio 45 | 10,625
Tchem 12 | 1,890
Tclin 11 | 602
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

decreased bone mineral content 3 | 157
decreased circulating fructosa... 3 | 31
decreased total body fat amoun... 3 | 186
preweaning lethality, complete... 3 | 633
abnormal behavioral response t... 2 | 52
abnormal bone structure 2 | 131
abnormal sleep behavior 2 | 63
convulsive seizures 2 | 11
decreased body weight 2 | 174
decreased lean body mass 2 | 195
increased blood urea nitrogen ... 2 | 44
increased mean corpuscular vol... 2 | 91
preweaning lethality, incomple... 2 | 260
abnormal coat/hair pigmentatio... 1 | 54
abnormal hair texture 1 | 4
abnormal placenta size 1 | 10
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal skin coloration 1 | 18
abnormal vocalization 1 | 21
absent startle reflex 1 | 15
decreased CD4-positive, CD25-p... 1 | 24
decreased NK T cell number 1 | 28
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased dendritic cell numbe... 1 | 3
decreased exploration in new e... 1 | 9
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased immature NK cell num... 1 | 1
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased startle reflex 1 | 48
decreased urine creatinine lev... 1 | 2
decreased vertical activity 1 | 22
edema 1 | 11
embryonic lethality prior to t... 1 | 187
fused cornea and lens 1 | 4
fusion of vertebral arches 1 | 7
hemorrhage 1 | 12
hydrops fetalis 1 | 22
improved glucose tolerance 1 | 56
increased CD4-positive, alpha ... 1 | 15
increased CD8-positive, alpha-... 1 | 11
increased KLRG1-positive NK ce... 1 | 9
increased Ly6C high monocyte n... 1 | 12
increased NK cell number 1 | 19
increased circulating alkaline... 1 | 119
increased circulating amylase ... 1 | 13
increased effector memory CD4-... 1 | 15
increased effector memory CD8-... 1 | 14
increased erythrocyte cell num... 1 | 26
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mature NK cell numbe... 1 | 1
increased mean corpuscular hem... 1 | 93
increased monocyte cell number 1 | 27
increased or absent threshold ... 1 | 128
increased plasmacytoid dendrit... 1 | 1
increased red blood cell distr... 1 | 21
prenatal lethality prior to he... 1 | 64
vertebral fusion 1 | 23

Disease

ovarian cancer 39 | 8,484
osteosarcoma 35 | 7,933
psoriasis 34 | 6,685
medulloblastoma, large-cell 27 | 6,234
glioblastoma 26 | 5,572
Carcinoma 22 | 2,147
Cancer 19 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
lung cancer 19 | 4,466
Breast cancer 18 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
pilocytic astrocytoma 18 | 3,086
atypical teratoid / rhabdoid tumor 17 | 4,369
non-small cell lung cancer 17 | 2,798
invasive ductal carcinoma 16 | 2,950
malignant mesothelioma 16 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
lung carcinoma 15 | 2,844
pancreatic cancer 15 | 2,300
acute quadriplegic myopathy 14 | 1,157
adult high grade glioma 14 | 2,148
primary pancreatic ductal adenocarcinoma 14 | 1,271
breast carcinoma 13 | 1,614
pediatric high grade glioma 13 | 2,712
juvenile dermatomyositis 12 | 1,189
lung adenocarcinoma 12 | 2,713
primitive neuroectodermal tumor 12 | 3,031
Duchenne muscular dystrophy 11 | 602
Ocular hypertension 11 | 27
colon cancer 11 | 1,475
cystic fibrosis 11 | 1,665
ependymoma 11 | 2,514
group 4 medulloblastoma 10 | 1,875
oligodendroglioma 10 | 2,849
subependymal giant cell astrocytoma 10 | 2,287
Acute lymphoid leukemia 9 | 25
Anaplastic large T-cell systemic malignant lymphoma 9 | 10
Burkitt's lymphoma 9 | 15
Carcinoma of breast 9 | 11
Carcinoma of female breast 9 | 20
Diffuse non-Hodgkin's lymphoma, large cell 9 | 12
Follicular non-Hodgkin's lymphoma 9 | 17
Gestational trophoblastic neoplasia 9 | 14
HER2-positive carcinoma of breast 9 | 10
Hodgkin's disease 9 | 18
Hypertensive disorder 9 | 58
Kaposi's sarcoma 9 | 20
Langerhans cell histiocytosis, disseminated 9 | 10
Liposarcoma 9 | 20
Malignant tumor of head and/or neck 9 | 15
Malignant tumor of ovary 9 | 25
Malignant tumor of prostate 9 | 11
Malignant tumor of stomach 9 | 12
Malignant tumor of testis 9 | 11
Metastatic Breast Carcinoma 9 | 21
Metastatic Prostate Carcinoma 9 | 18
Mycosis fungoides 9 | 28
Nephroblastoma 9 | 45
Neuroblastoma 9 | 78
Non-Hodgkin's lymphoma 9 | 22
Open-angle glaucoma 9 | 26
Pick disease 9 | 1,893
Rhabdomyosarcoma 9 | 29
Secondary malignant neoplasm of pancreas 9 | 10
Transitional cell carcinoma 9 | 18
astrocytic glioma 9 | 2,241
diabetes mellitus 9 | 1,663
medulloblastoma 9 | 1,524
posterior fossa group A ependymoma 9 | 1,511
Multiple myeloma 8 | 1,327
Waldenstrons macroglobulinemia 8 | 765
astrocytoma 8 | 1,493
atypical teratoid/rhabdoid tumor 8 | 1,095
pituitary cancer 8 | 1,972
ulcerative colitis 8 | 2,087
Becker muscular dystrophy 7 | 187
Rheumatoid Arthritis 7 | 1,160
ductal carcinoma in situ 7 | 1,745
interstitial cystitis 7 | 2,299
gastric cancer 6 | 430
nasopharyngeal carcinoma 6 | 1,056
tuberculosis 6 | 1,557
Amyotrophic Lateral Sclerosis 5 | 431
Animal Mammary Neoplasms 5 | 136
Cardiomyopathy 5 | 110
Distal arthrogryposis 5 | 45
Intellectual disability 5 | 573
Mammary Neoplasms, Experimental 5 | 150
Myopathy 5 | 128
Nonsyndromic deafness 5 | 121
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
hepatocellular carcinoma 5 | 532
posterior fossa group B ependymoma 5 | 1,530
spina bifida 5 | 1,064
Lissencephaly 4 | 61
Mammary Neoplasms 4 | 410
Ophthalmoplegia 4 | 18
dermatomyositis 4 | 933
interstitial lung disease 4 | 291
primary Sjogren syndrome 4 | 789

Tissue

Blood and immune system 70 | 17,995
Cardiovascular System 70 | 17,958
Digestive Tract 70 | 18,473
Endocrine System 70 | 18,512
Female tissues 70 | 18,647
Liver and Pancreas 70 | 18,136
Male tissues 70 | 17,969
Nervous System 70 | 18,561
Respiratory system 70 | 17,484
Urinary Tract 70 | 18,444
Skin and soft tissues 69 | 18,115

Target Family

Non-IDG 48 | 11,971
Kinase 14 | 634
Enzyme 8 | 4,146

PathwayCommons: panther Pathway

Cytoskeletal regulation by Rho... 70 | 70
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 82 | 82
untitled 79 | 79
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein phosphatase Slingshot homolog 1 SSH1 Tbio Enzyme -1.41770 25.0 106
Tubulin beta-2A chain TUBB2A Tclin Non-IDG -1.58651 36.1 215
Beta-actin-like protein 2 ACTBL2 Tdark Non-IDG -0.50618 4.39 46
Profilin-2 PFN2 Tbio Non-IDG -1.92449 89.6 196
Myosin-3 MYH3 Tbio Non-IDG -1.66510 45.6 38
Actin-related protein 2/3 complex subunit 5 ARPC5 Tbio Non-IDG -1.07398 11.5 63
Rho-associated protein kinase 2 ROCK2 Tclin Kinase -2.39656 248.3 472
Stathmin-4 STMN4 Tbio Non-IDG -2.00718 102.2 96
Vasodilator-stimulated phosphoprotein VASP Tbio Non-IDG -2.92544 883.0 726
LIM domain kinase 1 LIMK1 Tchem Kinase -2.22441 175.4 612