Development Level

Tbio 23 | 10,625
Tdark 5 | 7,003
Tchem 1 | 1,890
Tclin 1 | 602

IMPC Term

abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 24
decreased circulating phosphat... 1 | 15
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased erythrocyte cell num... 1 | 43
decreased gamma-delta T cell n... 1 | 18
decreased granulocyte number 1 | 8
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased late germinal center... 1 | 2
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased myeloid cell number ... 1 | 1
decreased pre-pro B cell numbe... 1 | 2
decreased prepulse inhibition 1 | 52
decreased pro-B cell number 1 | 2
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
immune system phenotype 1 | 17
increased B cell number 1 | 23
increased T cell number 1 | 15
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating calcium ... 1 | 32
increased early germinal cente... 1 | 2
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased immature B cell numb... 1 | 1
increased lean body mass 1 | 107
increased mature B cell number 1 | 12
increased pre-B cell number 1 | 1
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
vertebral fusion 1 | 23

Disease

osteosarcoma 21 | 7,933
medulloblastoma, large-cell 19 | 6,234
glioblastoma 16 | 5,572
ovarian cancer 15 | 8,484
pilocytic astrocytoma 14 | 3,086
atypical teratoid / rhabdoid tumor 13 | 4,369
psoriasis 13 | 6,685
ependymoma 12 | 2,514
primitive neuroectodermal tumor 12 | 3,031
Pick disease 11 | 1,893
oligodendroglioma 10 | 2,849
pediatric high grade glioma 10 | 2,712
lung carcinoma 9 | 2,844
malignant mesothelioma 9 | 3,162
subependymal giant cell astrocytoma 9 | 2,287
invasive ductal carcinoma 8 | 2,950
lung cancer 8 | 4,466
pituitary cancer 8 | 1,972
astrocytic glioma 7 | 2,241
astrocytoma 7 | 1,493
group 3 medulloblastoma 7 | 2,254
Breast cancer 6 | 3,094
Tetanus 6 | 66
adult high grade glioma 6 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
non-small cell lung cancer 6 | 2,798
ulcerative colitis 6 | 2,087
Multiple myeloma 5 | 1,327
colon cancer 5 | 1,475
ductal carcinoma in situ 5 | 1,745
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
juvenile dermatomyositis 5 | 1,189
Anxiety Disorders 4 | 37
Cancer 4 | 2,346
Cocaine-Related Disorders 4 | 88
Depressive disorder 4 | 48
Duchenne muscular dystrophy 4 | 602
Irritable bowel syndrome 4 | 59
Rheumatoid Arthritis 4 | 1,160
active Crohn's disease 4 | 918
breast carcinoma 4 | 1,614
chronic kidney disease 4 | 90
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
lung adenocarcinoma 4 | 2,713
medulloblastoma 4 | 1,524
pancreatic cancer 4 | 2,300
Alcohol dependence 3 | 107
Alzheimer's disease 3 | 644
Anorexia 3 | 15
Bipolar Disorder 3 | 266
Botulism 3 | 20
Down syndrome 3 | 548
Gaucher disease type 1 3 | 171
Hypertension 3 | 287
Hypertensive disease 3 | 193
Major Depressive Disorder 3 | 106
Melanoma 3 | 261
Neuropathy 3 | 210
Obesity 3 | 616
Osteoporosis 3 | 257
Panic disorder 3 | 55
Seizures 3 | 95
acute quadriplegic myopathy 3 | 1,157
adrenocortical carcinoma 3 | 1,427
cystic fibrosis 3 | 1,665
non primary Sjogren syndrome sicca 3 | 840
post-traumatic stress disorder 3 | 45
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271
tuberculosis 3 | 1,557
Acromegaly 2 | 40
Adenoma 2 | 165
Alopecia 2 | 55
Atopic dermatitis 2 | 944
Congenital Heart Defects 2 | 37
Cushing's syndrome 2 | 47
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Epilepsy 2 | 346
Hypoglycemia 2 | 81
Hypothyroidism 2 | 89
IGA Glomerulonephritis 2 | 454
Melancholia 2 | 12
Myocardial Ischemia 2 | 169
Neurodegenerative disease 2 | 383
Pain agnosia 2 | 99
Pituitary adenoma 2 | 35
Waldenstrons macroglobulinemia 2 | 765
Weight Gain 2 | 87
West Syndrome 2 | 23
active ulcerative colitis 2 | 477
atypical teratoid/rhabdoid tumor 2 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
dermatomyositis 2 | 933
glioblastoma multiforme 2 | 347
nasopharyngeal carcinoma 2 | 1,056
sarcoidosis 2 | 358
spina bifida 2 | 1,064
urothelial carcinoma 2 | 318

Tissue

Cardiovascular System 30 | 17,958
Digestive Tract 30 | 18,473
Endocrine System 30 | 18,512
Female tissues 30 | 18,647
Liver and Pancreas 30 | 18,136
Male tissues 30 | 17,969
Nervous System 30 | 18,561
Respiratory system 30 | 17,484
Skin and soft tissues 30 | 18,115
Urinary Tract 30 | 18,444
Blood and immune system 29 | 17,995

Target Family

Non-IDG 28 | 11,971
GPCR 2 | 406

PathwayCommons: panther Pathway

Cortocotropin releasing factor... 30 | 30
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Angiogenesis 141 | 141
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 82 | 82
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

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