Development Level

Tchem 78 | 1,890
Tbio 45 | 10,625
Tclin 16 | 602
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 12 | 633
decreased body weight 5 | 174
decreased bone mineral content 5 | 157
decreased lean body mass 4 | 195
abnormal behavior 3 | 226
abnormal bone mineralization 3 | 55
abnormal bone structure 3 | 131
decreased grip strength 3 | 123
embryonic lethality prior to t... 3 | 187
increased circulating alkaline... 3 | 119
increased lean body mass 3 | 107
preweaning lethality, incomple... 3 | 260
short tibia 3 | 82
abnormal embryo size 2 | 112
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal startle reflex 2 | 14
cataract 2 | 26
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating fructosa... 2 | 31
decreased circulating triglyce... 2 | 83
decreased lumbar vertebrae num... 2 | 62
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
enlarged lymph nodes 2 | 27
impaired glucose tolerance 2 | 52
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating choleste... 2 | 53
increased circulating iron lev... 2 | 25
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal femur morphology 1 | 14
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal head morphology 1 | 10
abnormal iris morphology 1 | 12
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal snout morphology 1 | 18
abnormal spinal cord morpholog... 1 | 8
abnormal testis morphology 1 | 30
absent heartbeat 1 | 6
decreased B cell number 1 | 30
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased kidney weight 1 | 7
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
decreased threshold for audito... 1 | 32
enlarged heart 1 | 111
hypoactivity 1 | 89
increased B cell number 1 | 23
increased T cell number 1 | 15
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating triglyce... 1 | 24
increased heart rate 1 | 17
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
male infertility 1 | 62
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
shortened RR interval 1 | 19
small testis 1 | 37
thrombocytosis 1 | 23

Disease

Cancer 95 | 2,346
ovarian cancer 87 | 8,484
osteosarcoma 84 | 7,933
psoriasis 69 | 6,685
glioblastoma 67 | 5,572
medulloblastoma, large-cell 64 | 6,234
lung cancer 60 | 4,466
atypical teratoid / rhabdoid tumor 50 | 4,369
Carcinoma 48 | 2,147
Breast cancer 45 | 3,094
ependymoma 41 | 2,514
oligodendroglioma 41 | 2,849
pilocytic astrocytoma 39 | 3,086
pediatric high grade glioma 38 | 2,712
invasive ductal carcinoma 36 | 2,950
non-small cell lung cancer 36 | 2,798
malignant mesothelioma 35 | 3,162
astrocytoma 34 | 1,493
lung adenocarcinoma 34 | 2,713
lung carcinoma 34 | 2,844
pancreatic cancer 34 | 2,300
primitive neuroectodermal tumor 33 | 3,031
group 4 medulloblastoma 31 | 1,875
interstitial cystitis 31 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,988
Mammary Neoplasms 30 | 410
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,289
breast carcinoma 27 | 1,614
cystic fibrosis 27 | 1,665
diabetes mellitus 26 | 1,663
pituitary cancer 26 | 1,972
ulcerative colitis 25 | 2,087
astrocytic glioma 23 | 2,241
subependymal giant cell astrocytoma 22 | 2,287
tuberculosis 22 | 1,557
group 3 medulloblastoma 21 | 2,254
Rheumatoid Arthritis 20 | 1,160
Vascular disease 20 | 281
colon cancer 20 | 1,475
ductal carcinoma in situ 20 | 1,745
juvenile dermatomyositis 20 | 1,189
primary pancreatic ductal adenocarcinoma 20 | 1,271
Lung Neoplasms 19 | 171
adrenocortical carcinoma 19 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
posterior fossa group A ependymoma 18 | 1,511
Heart disease 17 | 279
Kidney disease 17 | 396
Schizophrenia 17 | 501
medulloblastoma 17 | 1,524
Obesity 16 | 616
adult high grade glioma 16 | 2,148
dermatomyositis 16 | 933
spina bifida 16 | 1,064
Pick disease 15 | 1,893
Renal Cell Carcinoma 15 | 199
Prostatic Neoplasms 14 | 471
Stomach Neoplasms 14 | 282
sonic hedgehog group medulloblastoma 14 | 1,482
Alzheimer's disease 13 | 644
Cerebrovascular disease 13 | 231
Colorectal Neoplasms 13 | 217
atypical teratoid/rhabdoid tumor 13 | 1,095
non-small cell lung carcinoma 13 | 413
Atherosclerosis 12 | 275
Cardiomegaly 12 | 66
Liver carcinoma 12 | 217
Multiple myeloma 12 | 1,327
pancreatic carcinoma 12 | 567
primary Sjogren syndrome 12 | 789
Arthritis 11 | 248
Colonic Neoplasms 11 | 126
Intellectual disability 11 | 573
Parkinson's disease 11 | 364
acute myeloid leukemia 11 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
esophageal adenocarcinoma 11 | 737
gastric carcinoma 11 | 832
nasopharyngeal carcinoma 11 | 1,056
posterior fossa group B ependymoma 11 | 1,530
Atopic dermatitis 10 | 944
Hypertension 10 | 287
Osteoporosis 10 | 257
Squamous cell carcinoma 10 | 94
acute quadriplegic myopathy 10 | 1,157
glioblastoma multiforme 10 | 347
Adenocarcinoma 9 | 115
Hemangiosarcoma 9 | 18
Liver disease 9 | 219
Liver neoplasms 9 | 109
Lung disease 9 | 132
Myocardial Ischemia 9 | 169
Noonan Syndrome 9 | 33
Reperfusion Injury 9 | 84
Waldenstrons macroglobulinemia 9 | 765
aldosterone-producing adenoma 9 | 664
cutaneous lupus erythematosus 9 | 1,056
non primary Sjogren syndrome sicca 9 | 840
Asthma 8 | 349

Tissue

Cardiovascular System 140 | 17,958
Digestive Tract 140 | 18,473
Endocrine System 140 | 18,512
Female tissues 140 | 18,647
Liver and Pancreas 140 | 18,136
Male tissues 140 | 17,969
Nervous System 140 | 18,561
Respiratory system 140 | 17,484
Skin and soft tissues 140 | 18,115
Urinary Tract 140 | 18,444
Blood and immune system 139 | 17,995

Target Family

Kinase 53 | 634
Non-IDG 51 | 11,971
Enzyme 22 | 4,146
Transcription Factor 10 | 1,400
GPCR 5 | 406

PathwayCommons: panther Pathway

Angiogenesis 141 | 141
Wnt signaling pathway 250 | 250
Inflammation mediated by chemo... 187 | 187
Integrin signalling pathway 156 | 156
Cadherin signaling pathway 147 | 147
Heterotrimeric G-protein signa... 124 | 124
Huntington disease 113 | 113
PDGF signaling pathway 113 | 113
EGF receptor signaling pathway 109 | 109
Heterotrimeric G-protein signa... 105 | 105
Apoptosis signaling pathway 100 | 100
FGF signaling pathway 99 | 99
Alzheimer disease-presenilin p... 97 | 97
TGF-beta signaling pathway 88 | 88
Interleukin signaling pathway 86 | 86
Parkinson disease 82 | 82
untitled 79 | 79
Cytoskeletal regulation by Rho... 70 | 70
Ras Pathway 69 | 69
Nicotinic acetylcholine recept... 62 | 62
T cell activation 60 | 60
Alzheimer disease-amyloid secr... 56 | 56
Metabotropic glutamate recepto... 54 | 54
VEGF signaling pathway 54 | 54
B cell activation 52 | 52
PNAT 52 | 52
Toll receptor signaling pathwa... 44 | 44
Ubiquitin proteasome pathway 43 | 43
Ionotropic glutamate receptor ... 42 | 42
Transcription regulation by bZ... 42 | 42
p53 pathway feedback loops 2 42 | 42
Muscarinic acetylcholine recep... 41 | 41
Thyrotropin-releasing hormone ... 41 | 41
p53 pathway 39 | 39
Blood coagulation 38 | 38
Muscarinic acetylcholine recep... 38 | 38
PI3 kinase pathway 38 | 38
FAS signaling pathway 37 | 37
GABA-B_receptor_II_signaling 35 | 35
Angiotensin_II-stimulated_sign... 34 | 34
Oxytocin receptor mediated sig... 31 | 31
p38 MAPK pathway 31 | 31
5HT2 type receptor mediated s... 30 | 30
Axon guidance mediated by netr... 30 | 30
Cortocotropin releasing factor... 30 | 30
Heterotrimeric G-protein signa... 30 | 30
Insulin/IGF pathway-mitogen ac... 29 | 29
Interferon-gamma signaling pat... 29 | 29
Metabotropic glutamate recepto... 29 | 29
General transcription regulati... 28 | 28
Nicotine pharmacodynamics path... 28 | 28
5HT1 type receptor mediated s... 27 | 27
Notch signaling pathway 27 | 27
Histamine H1 receptor mediated... 26 | 26
Adrenaline and noradrenaline b... 25 | 25
De novo purine biosynthesis 25 | 25
Alpha adrenergic receptor sign... 23 | 23
Endogenous_cannabinoid_signali... 23 | 23
Metabotropic glutamate recepto... 23 | 23
Oxidative stress response 23 | 23
Insulin/IGF pathway-protein ki... 22 | 22
Synaptic_vesicle_trafficking 21 | 21
p53 pathway by glucose depriva... 21 | 21
Hedgehog signaling pathway 19 | 19
Axon guidance mediated by Slit... 18 | 18
DNA replication 18 | 18
Axon guidance mediated by sema... 17 | 17
Beta1 adrenergic receptor sign... 17 | 17
Enkephalin release 17 | 17
Glycolysis 17 | 17
5HT4 type receptor mediated s... 16 | 16
Hypoxia response via HIF activ... 16 | 16
Opioid proenkephalin pathway 16 | 16
Opioid proopiomelanocortin pat... 16 | 16
Plasminogen activating cascade 16 | 16
General transcription by RNA p... 15 | 15
JAK/STAT signaling pathway 15 | 15
Cell cycle 14 | 14
5HT3 type receptor mediated s... 13 | 13
Beta3 adrenergic receptor sign... 11 | 11
Cholesterol biosynthesis 11 | 11
De novo pyrimidine deoxyribonu... 10 | 10
De novo pyrimidine ribonucleot... 10 | 10
Heme biosynthesis 10 | 10
Pyrimidine Metabolism 10 | 10
Vasopressin synthesis 10 | 10
Beta2 adrenergic receptor sign... 9 | 9
Circadian clock system 9 | 9
Fructose galactose metabolism 9 | 9
Histamine H2 receptor mediated... 9 | 9
Salvage pyrimidine ribonucleot... 9 | 9
TCA cycle 9 | 9
Androgen/estrogene/progesteron... 8 | 8
Pentose phosphate pathway 8 | 8
Pyruvate metabolism 8 | 8
Nicotine_degradation 7 | 7
5-arachidonylglycerol_biosynt... 6 | 6
Coenzyme A biosynthesis 6 | 6
Mannose metabolism 6 | 6
P53 pathway feedback loops 1 6 | 6

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Delta-like protein 3 DLL3 Tbio Non-IDG -1.58510 42.7 181
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.07424 1194.2 1600
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 Tclin Kinase -1.78634 57.0 688
Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 Tchem Kinase -2.26683 181.8 641
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.37849 233.2 634
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.60410 3186.8 1232