Development Level

Tchem 34 | 1,598
Tbio 26 | 11,445
Tclin 13 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased body weight 3 | 161
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
decreased circulating creatini... 2 | 39
decreased vertical activity 2 | 208
increased circulating alkaline... 2 | 122
increased lymphocyte cell numb... 2 | 32
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal gait 1 | 69
abnormal skin condition 1 | 6
abnormal tooth morphology 1 | 24
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating free fat... 1 | 31
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating creatine... 1 | 5
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased heart left ventricle... 1 | 4
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
persistence of hyaloid vascula... 1 | 33

Disease

Cancer 60 | 2,499
Carcinoma 57 | 11,493
osteosarcoma 49 | 7,950
ovarian cancer 45 | 8,520
lung cancer 37 | 4,740
psoriasis 35 | 6,694
medulloblastoma, large-cell 31 | 6,241
glioblastoma 30 | 5,792
atypical teratoid / rhabdoid tumor 25 | 5,112
Breast cancer 23 | 3,578
Kidney cancer 22 | 2,613
malignant mesothelioma 21 | 3,232
Rheumatoid arthritis 19 | 1,191
astrocytoma 19 | 1,146
invasive ductal carcinoma 19 | 2,951
subependymal giant cell astrocytoma 19 | 2,287
Schizophrenia 18 | 1,160
adult high grade glioma 18 | 3,801
ependymoma 18 | 4,679
Arthritis 17 | 290
diabetes mellitus 17 | 1,728
tuberculosis 17 | 2,010
interstitial cystitis 16 | 2,312
lung carcinoma 16 | 2,843
oligodendroglioma 16 | 2,850
group 4 medulloblastoma 15 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
ulcerative colitis 15 | 1,819
Asthma 14 | 385
Astrocytoma, Pilocytic 14 | 3,081
Multiple myeloma 14 | 1,332
ductal carcinoma in situ 14 | 1,745
Obesity 13 | 678
group 3 medulloblastoma 13 | 4,104
juvenile dermatomyositis 13 | 1,187
lung adenocarcinoma 13 | 2,716
non-small cell lung cancer 13 | 2,890
pancreatic cancer 13 | 2,398
primary Sjogren syndrome 13 | 735
Carcinoma, Squamous Cell 12 | 110
Multiple Sclerosis 12 | 540
Squamous cell carcinoma 12 | 129
breast carcinoma 12 | 1,638
Atopic dermatitis 11 | 952
Inflammatory bowel disease 11 | 151
Prostatic Neoplasms 11 | 495
Vascular disease 11 | 319
cutaneous lupus erythematosus 11 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
Autosomal recessive predisposition 10 | 1,442
Breast Neoplasms 10 | 445
Carcinoma, Hepatocellular 10 | 228
Immune system cancer 10 | 140
Immunologic Deficiency Syndromes 10 | 113
Liver carcinoma 10 | 240
Mammary Neoplasms 10 | 425
Stomach Neoplasms 10 | 300
Waldenstrons macroglobulinemia 10 | 765
pituitary cancer 10 | 1,972
primary pancreatic ductal adenocarcinoma 10 | 1,109
Alzheimer's disease 9 | 658
Bipolar Disorder 9 | 666
Failure to gain weight 9 | 365
Infantile onset 9 | 238
Lung Neoplasms 9 | 232
Lung disease 9 | 142
Pediatric failure to thrive 9 | 365
Pick disease 9 | 1,894
cystic fibrosis 9 | 1,696
primitive neuroectodermal tumor 9 | 3,035
spina bifida 9 | 1,074
Brain Ischemia 8 | 110
Frontal bossing 8 | 157
Hyperglycemia 8 | 137
Liver Cirrhosis, Experimental 8 | 769
Lymphoid leukemia 8 | 160
Pneumonia 8 | 174
Renal Cell Carcinoma 8 | 214
Short stature 8 | 531
Acquired scoliosis 7 | 281
Anemia 7 | 365
Blepharoptosis 7 | 231
Byzanthine arch palate 7 | 194
Chronic Lymphocytic Leukemia 7 | 262
Crohn's disease 7 | 321
Curvature of spine 7 | 282
Delayed bone age 7 | 136
Hypersensitivity reaction type II disease 7 | 253
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Orbital separation excessive 7 | 244
Pectus excavatum 7 | 100
Splenomegaly 7 | 190
active ulcerative colitis 7 | 764
acute myeloid leukemia 7 | 783
acute quadriplegic myopathy 7 | 1,158
hearing impairment 7 | 199
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962

Tissue

Blood and immune system 73 | 16,909
Digestive Tract 73 | 17,369
Endocrine System 73 | 18,159
Liver and Pancreas 73 | 16,750
Male tissues 73 | 17,142
Respiratory system 73 | 16,393
Skin and soft tissues 73 | 17,230
Urinary Tract 73 | 16,678
Female tissues 72 | 17,400
Nervous System 72 | 16,725
Cardiovascular System 71 | 15,192

Target Family

Kinase 25 | 634
Non-IDG 22 | 12,091
Transcription Factor 13 | 1,400
Enzyme 8 | 4,145
Epigenetic 4 | 242
GPCR 1 | 408

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Staphylococcal nuclease domain-containing protein 1 SND1 Tbio Epigenetic -2.35812 225.9 175
Suppressor of cytokine signaling 5 SOCS5 Tbio Non-IDG -2.04740 106.6 135
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Tumor necrosis factor receptor superfamily member 5 CD40 Tchem Non-IDG -3.50040 3120.3 1879
Protein C-ets-1 ETS1 Tbio Transcription Factor -2.89500 760.0 463
CCAAT/enhancer-binding protein alpha CEBPA Tbio Transcription Factor -2.94393 846.3 518
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818