Development Level

Tbio 78 | 11,445
Tchem 61 | 1,598
Tclin 21 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 12 | 979
decreased body weight 5 | 161
preweaning lethality, incomple... 5 | 499
decreased total body fat amoun... 4 | 207
increased total body fat amoun... 4 | 134
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
abnormal gait 3 | 69
abnormal lens morphology 3 | 81
abnormal skin morphology 3 | 50
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased vertical activity 3 | 208
embryonic lethality prior to t... 3 | 278
increased monocyte cell number 3 | 63
increased neutrophil cell numb... 3 | 46
small superior vagus ganglion 3 | 74
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased heart left ventricle... 2 | 28
decreased hemoglobin content 2 | 68
decreased mature B cell number 2 | 7
decreased mean corpuscular vol... 2 | 79
edema 2 | 59
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
male infertility 2 | 123
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal maxilla morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
absent vibrissae 1 | 12
anophthalmia 1 | 33
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased spleen weight 1 | 10
increased startle reflex 1 | 112
mammalian phenotype 1 | 17
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
short tibia 1 | 97
small epididymis 1 | 3
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

osteosarcoma 113 | 7,950
Carcinoma 112 | 11,493
Cancer 100 | 2,499
ovarian cancer 90 | 8,520
glioblastoma 78 | 5,792
psoriasis 77 | 6,694
lung cancer 70 | 4,740
medulloblastoma, large-cell 66 | 6,241
ependymoma 51 | 4,679
interstitial cystitis 48 | 2,312
ulcerative colitis 47 | 1,819
Kidney cancer 46 | 2,613
atypical teratoid / rhabdoid tumor 45 | 5,112
lung carcinoma 45 | 2,843
group 3 medulloblastoma 42 | 4,104
Breast cancer 41 | 3,578
subependymal giant cell astrocytoma 41 | 2,287
adult high grade glioma 40 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
tuberculosis 39 | 2,010
primary Sjogren syndrome 38 | 735
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
non-small cell lung cancer 37 | 2,890
invasive ductal carcinoma 36 | 2,951
oligodendroglioma 36 | 2,850
Astrocytoma, Pilocytic 34 | 3,081
cutaneous lupus erythematosus 33 | 1,057
lung adenocarcinoma 32 | 2,716
malignant mesothelioma 32 | 3,232
primitive neuroectodermal tumor 32 | 3,035
Rheumatoid arthritis 30 | 1,191
diabetes mellitus 30 | 1,728
group 4 medulloblastoma 30 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
astrocytoma 28 | 1,146
colon cancer 26 | 1,478
pancreatic cancer 26 | 2,398
Autosomal recessive predisposition 25 | 1,442
Pick disease 25 | 1,894
Vascular disease 25 | 319
astrocytic glioma 25 | 2,597
Arthritis 23 | 290
Schizophrenia 23 | 1,160
pituitary cancer 23 | 1,972
Multiple myeloma 22 | 1,332
Immunologic Deficiency Syndromes 20 | 113
Obesity 20 | 678
juvenile dermatomyositis 20 | 1,187
Alzheimer's disease 19 | 658
adrenocortical carcinoma 19 | 1,428
dermatomyositis 18 | 966
Liver Cirrhosis, Experimental 17 | 769
Short stature 17 | 531
Waldenstrons macroglobulinemia 17 | 765
breast carcinoma 17 | 1,638
cystic fibrosis 17 | 1,696
primary pancreatic ductal adenocarcinoma 17 | 1,109
spina bifida 17 | 1,074
Asthma 16 | 385
Breast Neoplasms 16 | 445
Kidney disease 16 | 430
Lung Neoplasms 16 | 232
Mammary Neoplasms 16 | 425
Melanoma 16 | 711
Multiple Sclerosis 16 | 540
gastric carcinoma 16 | 807
Brain Ischemia 15 | 110
Chronic Lymphocytic Leukemia 15 | 262
Intellectual disability 15 | 1,016
acute myeloid leukemia 15 | 783
nasopharyngeal carcinoma 15 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
pediatric high grade glioma 15 | 1,064
Chronic otitis media 14 | 52
Cognitive delay 14 | 608
Dull intelligence 14 | 645
Fever 14 | 138
Global developmental delay 14 | 608
Low intelligence 14 | 645
Lung disease 14 | 142
Mental Retardation 14 | 645
Mental and motor retardation 14 | 608
Mental deficiency 14 | 645
Muscle hypotonia 14 | 571
Orbital separation excessive 14 | 244
Poor school performance 14 | 645
ear infection chronic 14 | 52
Bipolar Disorder 13 | 666
Blepharoptosis 13 | 231
Infantile onset 13 | 238
Parkinson's disease 13 | 392
Prostatic Neoplasms 13 | 495
Splenomegaly 13 | 190
medulloblastoma 13 | 720
Acquired scoliosis 12 | 281
Curvature of spine 12 | 282
Hepatomegaly 12 | 285
Inflammatory bowel disease 12 | 151
aldosterone-producing adenoma 12 | 665
ductal carcinoma in situ 12 | 1,745

Tissue

Blood and immune system 158 | 16,909
Cardiovascular System 158 | 15,192
Digestive Tract 158 | 17,369
Endocrine System 158 | 18,159
Female tissues 158 | 17,400
Liver and Pancreas 158 | 16,750
Male tissues 158 | 17,142
Respiratory system 158 | 16,393
Skin and soft tissues 158 | 17,230
Urinary Tract 158 | 16,678
Nervous System 155 | 16,725

Target Family

Non-IDG 66 | 12,091
Kinase 53 | 634
Enzyme 19 | 4,145
Transcription Factor 18 | 1,400
Epigenetic 2 | 242
Ion Channel 2 | 344
Transporter 1 | 473

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Caspase recruitment domain-containing protein 11 CARD11 Tbio Enzyme -2.17228 139.2 235
Ras-related protein R-Ras2 RRAS2 Tbio Enzyme -1.56623 42.9 157
Tyrosine-protein phosphatase non-receptor type 18 PTPN18 Tbio Enzyme -0.77241 5.46 77
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598