Development Level

Tbio 41 | 11,445
Tchem 34 | 1,598
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
increased total body fat amoun... 4 | 134
abnormal behavior 3 | 298
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
increased lean body mass 3 | 172
preweaning lethality, incomple... 3 | 499
abnormal bone mineralization 2 | 38
abnormal gait 2 | 69
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to t... 2 | 278
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
male infertility 2 | 123
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
absent vibrissae 1 | 12
decreased IgG3 level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired righting response 1 | 26
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart left ventricle... 1 | 4
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 66 | 11,493
Cancer 63 | 2,499
ovarian cancer 53 | 8,520
osteosarcoma 51 | 7,950
lung cancer 43 | 4,740
glioblastoma 38 | 5,792
psoriasis 38 | 6,694
medulloblastoma, large-cell 33 | 6,241
atypical teratoid / rhabdoid tumor 28 | 5,112
Kidney cancer 25 | 2,613
tuberculosis 25 | 2,010
pancreatic cancer 24 | 2,398
Breast cancer 22 | 3,578
ependymoma 22 | 4,679
Rheumatoid arthritis 21 | 1,191
diabetes mellitus 21 | 1,728
lung carcinoma 21 | 2,843
non-small cell lung cancer 21 | 2,890
adult high grade glioma 20 | 3,801
malignant mesothelioma 19 | 3,232
subependymal giant cell astrocytoma 19 | 2,287
group 3 medulloblastoma 18 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
oligodendroglioma 18 | 2,850
Arthritis 17 | 290
lung adenocarcinoma 17 | 2,716
Astrocytoma, Pilocytic 16 | 3,081
Pick disease 16 | 1,894
Vascular disease 16 | 319
group 4 medulloblastoma 16 | 1,855
interstitial cystitis 16 | 2,312
juvenile dermatomyositis 16 | 1,187
Schizophrenia 15 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
primitive neuroectodermal tumor 15 | 3,035
Multiple myeloma 14 | 1,332
astrocytoma 14 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
invasive ductal carcinoma 14 | 2,951
ulcerative colitis 14 | 1,819
Alzheimer's disease 13 | 658
Autosomal recessive predisposition 13 | 1,442
dermatomyositis 13 | 966
pituitary cancer 13 | 1,972
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
Obesity 12 | 678
cystic fibrosis 12 | 1,696
Asthma 11 | 385
astrocytic glioma 11 | 2,597
colon cancer 11 | 1,478
Epilepsy 10 | 792
Kidney disease 10 | 430
Lung disease 10 | 142
Osteopetrosis 10 | 43
Osteoporosis 10 | 363
Parkinson's disease 10 | 392
Stomach Neoplasms 10 | 300
Waldenstrons macroglobulinemia 10 | 765
primary Sjogren syndrome 10 | 735
Carcinoma, Hepatocellular 9 | 228
Liver carcinoma 9 | 240
Lung Neoplasms 9 | 232
Multiple Sclerosis 9 | 540
Prostatic Neoplasms 9 | 495
acute quadriplegic myopathy 9 | 1,158
ductal carcinoma in situ 9 | 1,745
primary pancreatic ductal adenocarcinoma 9 | 1,109
spina bifida 9 | 1,074
Anemia 8 | 365
Brain Ischemia 8 | 110
Hyperglycemia 8 | 137
Seizures 8 | 596
Toxic encephalopathy 8 | 141
active Crohn's disease 8 | 922
acute myeloid leukemia 8 | 783
cutaneous lupus erythematosus 8 | 1,057
Amyotrophic lateral sclerosis 7 | 451
Arthritis, Rheumatoid 7 | 174
Bipolar Disorder 7 | 666
Chronic Lymphocytic Leukemia 7 | 262
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Hypertensive disease 7 | 292
Immunologic Deficiency Syndromes 7 | 113
Inflammatory bowel disease 7 | 151
Liver Cirrhosis, Experimental 7 | 769
Melanoma 7 | 711
Mental and motor retardation 7 | 608
Neoplasm Invasiveness 7 | 161
Neoplasm Metastasis 7 | 168
Recurrent respiratory infections 7 | 141
Renal Cell Carcinoma 7 | 214
Short stature 7 | 531
Thrombocytopenia 7 | 197
breast carcinoma 7 | 1,638
gastric carcinoma 7 | 807
mucosa-associated lymphoid tissue lymphoma 7 | 484
nasopharyngeal carcinoma 7 | 1,058

Tissue

Blood and immune system 84 | 16,909
Digestive Tract 84 | 17,369
Respiratory system 84 | 16,393
Skin and soft tissues 84 | 17,230
Urinary Tract 84 | 16,678
Endocrine System 83 | 18,159
Female tissues 83 | 17,400
Liver and Pancreas 83 | 16,750
Male tissues 83 | 17,142
Cardiovascular System 82 | 15,192
Nervous System 82 | 16,725

Target Family

Kinase 30 | 634
Non-IDG 26 | 12,091
Transcription Factor 16 | 1,400
Enzyme 11 | 4,145
Epigenetic 1 | 242

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor receptor superfamily member 11A TNFRSF11A Tbio Non-IDG -3.26478 1689.0 464
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Signal-regulatory protein beta-1 isoform 3 SIRPB1 Tbio Non-IDG -0.77740 8.38 192
Forkhead box protein O4 FOXO4 Tbio Transcription Factor -2.43923 278.0 720
V-type proton ATPase subunit E 1 ATP6V1E1 Tbio Enzyme -1.04091 10.7 137
Osteoclast-associated immunoglobulin-like receptor OSCAR Tbio Non-IDG 0.00000 169
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494