Development Level

Tbio 31 | 11,445
Tchem 4 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
preweaning lethality, complete... 3 | 979
abnormal retina morphology 2 | 71
corneal opacity 2 | 32
decreased body weight 2 | 161
decreased total body fat amoun... 2 | 207
increased bone mineral density 2 | 72
increased heart weight 2 | 62
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal eyelid morphology 1 | 7
abnormal gait 1 | 69
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal placement of pupils 1 | 6
cataract 1 | 92
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased threshold for audito... 1 | 26
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
thrombocytopenia 1 | 56

Disease

Carcinoma 29 | 11,493
Cancer 27 | 2,499
ovarian cancer 26 | 8,520
osteosarcoma 23 | 7,950
glioblastoma 22 | 5,792
psoriasis 22 | 6,694
medulloblastoma, large-cell 21 | 6,241
atypical teratoid / rhabdoid tumor 18 | 5,112
oligodendroglioma 18 | 2,850
ependymoma 17 | 4,679
lung cancer 16 | 4,740
malignant mesothelioma 16 | 3,232
group 3 medulloblastoma 14 | 4,104
Astrocytoma, Pilocytic 13 | 3,081
astrocytic glioma 13 | 2,597
primitive neuroectodermal tumor 12 | 3,035
Breast cancer 11 | 3,578
juvenile dermatomyositis 11 | 1,187
lung adenocarcinoma 11 | 2,716
Pick disease 10 | 1,894
interstitial cystitis 10 | 2,312
pancreatic cancer 10 | 2,398
pituitary cancer 10 | 1,972
tuberculosis 10 | 2,010
Kidney cancer 9 | 2,613
acute quadriplegic myopathy 9 | 1,158
adult high grade glioma 9 | 3,801
group 4 medulloblastoma 9 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
non-small cell lung cancer 9 | 2,890
adrenocortical carcinoma 8 | 1,428
dermatomyositis 8 | 966
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
invasive ductal carcinoma 8 | 2,951
Down syndrome 7 | 499
Liver Cirrhosis, Experimental 7 | 769
Multiple myeloma 7 | 1,332
Orbital separation excessive 7 | 244
active ulcerative colitis 7 | 764
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Breast Neoplasms 6 | 445
Intellectual disability 6 | 1,016
Lung Neoplasms 6 | 232
Mammary Neoplasms 6 | 425
Muscle hypotonia 6 | 571
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
Short stature 6 | 531
aldosterone-producing adenoma 6 | 665
astrocytoma 6 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
breast carcinoma 6 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
primary pancreatic ductal adenocarcinoma 6 | 1,109
subependymal giant cell astrocytoma 6 | 2,287
Acquired scoliosis 5 | 281
Chronic Lymphocytic Leukemia 5 | 262
Cognitive delay 5 | 608
Cryptorchidism 5 | 296
Curvature of spine 5 | 282
Duchenne muscular dystrophy 5 | 601
Dull intelligence 5 | 645
Global developmental delay 5 | 608
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Poor school performance 5 | 645
Short neck 5 | 140
Strabismus 5 | 270
Vascular disease 5 | 319
ductal carcinoma in situ 5 | 1,745
gastric carcinoma 5 | 807
lung carcinoma 5 | 2,843
nephrosclerosis 5 | 333
pediatric high grade glioma 5 | 1,064
primary Sjogren syndrome 5 | 735
Bipolar Disorder 4 | 666
Brain Ischemia 4 | 110
Byzanthine arch palate 4 | 194
Concave bridge of nose 4 | 195
Congenital Epicanthus 4 | 177
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Feeding difficulties in infancy 4 | 175
Hypoplastic mandible condyle 4 | 275
Kidney disease 4 | 430
Multiple Sclerosis 4 | 540
Parkinson's disease 4 | 392
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 922
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
esophageal adenocarcinoma 4 | 737
gastric cancer 4 | 459
hepatocellular carcinoma 4 | 547
nasopharyngeal carcinoma 4 | 1,058
ulcerative colitis 4 | 1,819

Tissue

Digestive Tract 37 | 17,369
Male tissues 36 | 17,142
Skin and soft tissues 36 | 17,230
Endocrine System 35 | 18,159
Female tissues 35 | 17,400
Nervous System 35 | 16,725
Urinary Tract 35 | 16,678
Blood and immune system 33 | 16,909
Respiratory system 32 | 16,393
Cardiovascular System 31 | 15,192
Liver and Pancreas 31 | 16,750

Target Family

Transcription Factor 25 | 1,400
Kinase 6 | 634
Non-IDG 5 | 12,091
Enzyme 2 | 4,145

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ETS domain-containing protein Elk-4 ELK4 Tbio Transcription Factor -1.07328 11.4 100
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.68609 492.0 349
Oligodendrocyte transcription factor 2 OLIG2 Tbio Transcription Factor -2.64017 420.5 368
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
ETS domain-containing protein Elk-3 ELK3 Tbio Transcription Factor -0.17124 0.86 225
DNA-binding protein inhibitor ID-4 ID4 Tbio Transcription Factor -2.22096 177.3 245
Paired box protein Pax-8 PAX8 Tbio Transcription Factor -2.64765 442.1 540
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Four and a half LIM domains protein 2 FHL2 Tbio Non-IDG -2.60042 385.8 253
Transcription factor 12 TCF12 Tbio Transcription Factor -2.24606 159.8 253