Development Level

Tchem 34 | 1,598
Tbio 29 | 11,445
Tclin 6 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
enlarged spleen 2 | 41
increased circulating alkaline... 2 | 122
increased lean body mass 2 | 172
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal motor learning 1 | 3
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
absent vibrissae 1 | 12
brachydactyly 1 | 19
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased coping response 1 | 8
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 50 | 11,493
Cancer 44 | 2,499
ovarian cancer 41 | 8,520
glioblastoma 38 | 5,792
osteosarcoma 37 | 7,950
psoriasis 35 | 6,694
lung cancer 32 | 4,740
atypical teratoid / rhabdoid tumor 29 | 5,112
medulloblastoma, large-cell 29 | 6,241
Rheumatoid arthritis 20 | 1,191
adult high grade glioma 20 | 3,801
Breast cancer 19 | 3,578
ependymoma 19 | 4,679
malignant mesothelioma 18 | 3,232
oligodendroglioma 18 | 2,850
Schizophrenia 17 | 1,160
diabetes mellitus 17 | 1,728
pancreatic cancer 17 | 2,398
Arthritis 16 | 290
Vascular disease 16 | 319
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
tuberculosis 16 | 2,010
Astrocytoma, Pilocytic 15 | 3,081
Brain Ischemia 15 | 110
group 4 medulloblastoma 15 | 1,855
Asthma 14 | 385
subependymal giant cell astrocytoma 14 | 2,287
Kidney cancer 13 | 2,613
Pick disease 13 | 1,894
non-small cell lung cancer 13 | 2,890
primitive neuroectodermal tumor 13 | 3,035
Alzheimer's disease 12 | 658
dermatomyositis 12 | 966
group 3 medulloblastoma 12 | 4,104
lung adenocarcinoma 12 | 2,716
lung carcinoma 12 | 2,843
pituitary cancer 12 | 1,972
Inflammatory bowel disease 11 | 151
Lung Neoplasms 11 | 232
breast carcinoma 11 | 1,638
interstitial cystitis 11 | 2,312
invasive ductal carcinoma 11 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Bipolar Disorder 10 | 666
Breast Neoplasms 10 | 445
Depressive disorder 10 | 409
Disease Models, Animal 10 | 155
Multiple myeloma 10 | 1,332
Obesity 10 | 678
Parkinson's disease 10 | 392
Reperfusion Injury 10 | 86
Short stature 10 | 531
astrocytic glioma 10 | 2,597
cystic fibrosis 10 | 1,696
spina bifida 10 | 1,074
ulcerative colitis 10 | 1,819
Autosomal recessive predisposition 9 | 1,442
Cholestasis, Extrahepatic 9 | 25
Hyperglycemia 9 | 137
Lung disease 9 | 142
Mammary Neoplasms 9 | 425
Orbital separation excessive 9 | 244
Prostatic Neoplasms 9 | 495
Toxic encephalopathy 9 | 141
acute quadriplegic myopathy 9 | 1,158
astrocytoma 9 | 1,146
colon cancer 9 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
juvenile dermatomyositis 9 | 1,187
Acquired scoliosis 8 | 281
Cell Transformation, Neoplastic 8 | 97
Curvature of spine 8 | 282
Hyperalgesia 8 | 83
Hypertension 8 | 396
Mental Depression 8 | 333
Neoplastic Cell Transformation 8 | 89
Stomach Neoplasms 8 | 300
acute myeloid leukemia 8 | 783
ductal carcinoma in situ 8 | 1,745
primary pancreatic ductal adenocarcinoma 8 | 1,109
Byzanthine arch palate 7 | 194
Colonic Neoplasms 7 | 142
Dull intelligence 7 | 645
Frontal bossing 7 | 157
Heart disease 7 | 306
Hypersensitivity reaction type II disease 7 | 253
Hypertensive disease 7 | 292
Inflammation 7 | 120
Intellectual disability 7 | 1,016
Kidney disease 7 | 430
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Multiple Sclerosis 7 | 540
Neoplasm Invasiveness 7 | 161
Pneumonia 7 | 174
Poor school performance 7 | 645
adrenocortical carcinoma 7 | 1,428
pancreatic carcinoma 7 | 562

Tissue

Blood and immune system 68 | 16,909
Digestive Tract 68 | 17,369
Endocrine System 68 | 18,159
Female tissues 68 | 17,400
Liver and Pancreas 68 | 16,750
Male tissues 68 | 17,142
Nervous System 68 | 16,725
Respiratory system 68 | 16,393
Skin and soft tissues 68 | 17,230
Urinary Tract 68 | 16,678
Cardiovascular System 67 | 15,192

Target Family

Kinase 28 | 634
Non-IDG 24 | 12,091
Enzyme 11 | 4,145
Transcription Factor 6 | 1,400

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 Tbio Non-IDG -1.33153 18.0 188
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.47034 26.6 199
Eukaryotic translation initiation factor 2-alpha kinase 3 EIF2AK3 Tchem Kinase -3.05781 896.8 450
Serine/threonine-protein phosphatase 6 catalytic subunit PPP6C Tbio Enzyme -2.41091 208.5 230
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Dual specificity mitogen-activated protein kinase kinase 7 MAP2K7 Tchem Kinase -3.66356 3766.3 513
Cytosolic phospholipase A2 PLA2G4A Tchem Enzyme -2.68316 506.7 274
F-box/WD repeat-containing protein 5 FBXW5 Tbio Non-IDG -0.48379 3.50 107