Development Level

Tchem 36 | 1,598
Tbio 30 | 11,445
Tclin 17 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 4 | 499
abnormal bone structure 2 | 187
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
increased blood urea nitrogen ... 2 | 48
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal ovary morphology 1 | 7
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
absent epididymis 1 | 3
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hypoactivity 1 | 132
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased heart left ventricle... 1 | 4
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
shortened RR interval 1 | 17

Disease

Carcinoma 67 | 11,493
Cancer 65 | 2,499
osteosarcoma 57 | 7,950
ovarian cancer 57 | 8,520
glioblastoma 46 | 5,792
medulloblastoma, large-cell 41 | 6,241
lung cancer 37 | 4,740
psoriasis 35 | 6,694
atypical teratoid / rhabdoid tumor 30 | 5,112
ependymoma 28 | 4,679
Breast cancer 26 | 3,578
group 3 medulloblastoma 25 | 4,104
adult high grade glioma 24 | 3,801
Kidney cancer 23 | 2,613
diabetes mellitus 23 | 1,728
invasive ductal carcinoma 23 | 2,951
malignant mesothelioma 23 | 3,232
tuberculosis 23 | 2,010
Schizophrenia 22 | 1,160
group 4 medulloblastoma 22 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
lung carcinoma 21 | 2,843
subependymal giant cell astrocytoma 21 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
non-small cell lung cancer 20 | 2,890
Multiple myeloma 19 | 1,332
oligodendroglioma 19 | 2,850
Astrocytoma, Pilocytic 18 | 3,081
interstitial cystitis 18 | 2,312
lung adenocarcinoma 18 | 2,716
Rheumatoid arthritis 17 | 1,191
Vascular disease 17 | 319
astrocytic glioma 17 | 2,597
primitive neuroectodermal tumor 16 | 3,035
ulcerative colitis 16 | 1,819
Alzheimer's disease 15 | 658
Waldenstrons macroglobulinemia 15 | 765
pancreatic cancer 15 | 2,398
Pick disease 14 | 1,894
juvenile dermatomyositis 14 | 1,187
primary Sjogren syndrome 14 | 735
astrocytoma 13 | 1,146
dermatomyositis 13 | 966
pituitary cancer 13 | 1,972
Arthritis 12 | 290
Bipolar Disorder 12 | 666
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
Short stature 12 | 531
colon cancer 12 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
Anemia 11 | 365
Heart disease 11 | 306
Lung Neoplasms 11 | 232
Obesity 11 | 678
Prostatic Neoplasms 11 | 495
Stomach Neoplasms 11 | 300
cutaneous lupus erythematosus 11 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
spina bifida 11 | 1,074
Asthma 10 | 385
Liver Cirrhosis, Experimental 10 | 769
Orbital separation excessive 10 | 244
adrenocortical carcinoma 10 | 1,428
cystic fibrosis 10 | 1,696
Blepharoptosis 9 | 231
Carcinoma, Squamous Cell 9 | 110
Cognitive delay 9 | 608
Depressive disorder 9 | 409
Dull intelligence 9 | 645
Global developmental delay 9 | 608
Hyperglycemia 9 | 137
Immune system cancer 9 | 140
Intellectual disability 9 | 1,016
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Muscle hypotonia 9 | 571
Parkinson's disease 9 | 392
Poor school performance 9 | 645
Squamous cell carcinoma 9 | 129
ductal carcinoma in situ 9 | 1,745
pediatric high grade glioma 9 | 1,064
primary pancreatic ductal adenocarcinoma 9 | 1,109
Carcinoma, Hepatocellular 8 | 228
Cell Transformation, Neoplastic 8 | 97
Congenital Epicanthus 8 | 177
Hypoplastic mandible condyle 8 | 275
Kidney disease 8 | 430
Liver Neoplasms, Experimental 8 | 59
Liver carcinoma 8 | 240
Mandibular hypoplasia 8 | 275
Melanoma 8 | 711
Micrognathism 8 | 275
Renal Cell Carcinoma 8 | 214
Splenomegaly 8 | 190
breast carcinoma 8 | 1,638
mucosa-associated lymphoid tissue lymphoma 8 | 484
Crohn's disease 7 | 321

Tissue

Blood and immune system 84 | 16,909
Endocrine System 84 | 18,159
Male tissues 84 | 17,142
Digestive Tract 83 | 17,369
Female tissues 83 | 17,400
Liver and Pancreas 83 | 16,750
Nervous System 83 | 16,725
Respiratory system 83 | 16,393
Skin and soft tissues 83 | 17,230
Urinary Tract 83 | 16,678
Cardiovascular System 82 | 15,192

Target Family

Non-IDG 33 | 12,091
Kinase 27 | 634
Transcription Factor 11 | 1,400
Enzyme 9 | 4,145
Nuclear Receptor 2 | 48
Ion Channel 1 | 344
Transporter 1 | 473

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Calsenilin KCNIP3 Tbio Ion Channel -1.72310 56.0 369
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492