Development Level

Tbio 46 | 11,445
Tchem 23 | 1,598
Tclin 6 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 10 | 979
decreased body weight 3 | 161
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal vibrissa morphology 2 | 25
decreased bone mineral density 2 | 126
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
enlarged heart 2 | 210
enlarged kidney 2 | 14
increased blood urea nitrogen ... 2 | 48
increased grip strength 2 | 41
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal eating behavior 1 | 1
abnormal embryo size 1 | 220
abnormal esophagus morphology 1 | 5
abnormal femur morphology 1 | 14
abnormal forced expiratory flo... 1 | 1
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin condition 1 | 6
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased body temperature 1 | 2
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased coping response 1 | 8
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased tidal volume 1 | 1
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged gallbladder 1 | 2
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
improved glucose tolerance 1 | 79
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
premature death 1 | 5
respiratory system phenotype 1 | 2
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 58 | 11,493
ovarian cancer 50 | 8,520
Cancer 46 | 2,499
osteosarcoma 42 | 7,950
glioblastoma 39 | 5,792
psoriasis 38 | 6,694
medulloblastoma, large-cell 37 | 6,241
lung cancer 31 | 4,740
atypical teratoid / rhabdoid tumor 29 | 5,112
ependymoma 28 | 4,679
oligodendroglioma 27 | 2,850
Breast cancer 26 | 3,578
group 3 medulloblastoma 23 | 4,104
primitive neuroectodermal tumor 23 | 3,035
Astrocytoma, Pilocytic 21 | 3,081
adult high grade glioma 20 | 3,801
astrocytic glioma 20 | 2,597
Alzheimer's disease 19 | 658
Breast Neoplasms 19 | 445
Kidney cancer 19 | 2,613
Mammary Neoplasms 18 | 425
malignant mesothelioma 18 | 3,232
Schizophrenia 17 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
tuberculosis 16 | 2,010
Rheumatoid arthritis 15 | 1,191
astrocytoma 15 | 1,146
invasive ductal carcinoma 15 | 2,951
non-small cell lung cancer 15 | 2,890
pediatric high grade glioma 15 | 1,064
subependymal giant cell astrocytoma 15 | 2,287
Pick disease 14 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
pituitary cancer 14 | 1,972
diabetes mellitus 13 | 1,728
group 4 medulloblastoma 13 | 1,855
interstitial cystitis 13 | 2,312
lung carcinoma 13 | 2,843
juvenile dermatomyositis 12 | 1,187
Carcinoma, Squamous Cell 11 | 110
Acquired scoliosis 10 | 281
Curvature of spine 10 | 282
Failure to gain weight 10 | 365
Multiple myeloma 10 | 1,332
Orbital separation excessive 10 | 244
Pediatric failure to thrive 10 | 365
lung adenocarcinoma 10 | 2,716
ulcerative colitis 10 | 1,819
Bipolar Disorder 9 | 666
Heart disease 9 | 306
Vascular disease 9 | 319
breast carcinoma 9 | 1,638
colon cancer 9 | 1,478
ductal carcinoma in situ 9 | 1,745
Arthritis 8 | 290
Brain Ischemia 8 | 110
Carcinoma, Pancreatic Ductal 8 | 20
Crohn's disease 8 | 321
Dementia 8 | 175
Epilepsy 8 | 792
Immune system cancer 8 | 140
Intellectual disability 8 | 1,016
Seizures 8 | 596
Short stature 8 | 531
dermatomyositis 8 | 966
Asthma 7 | 385
Byzanthine arch palate 7 | 194
Cataract 7 | 297
Colonic Neoplasms 7 | 142
Depressive disorder 7 | 409
Disease Models, Animal 7 | 155
Down syndrome 7 | 499
Kidney disease 7 | 430
Lens Opacities 7 | 231
Liver cancer 7 | 604
Lung Neoplasms 7 | 232
Lymphoid leukemia 7 | 160
Mood Disorders 7 | 184
Neurodegenerative disease 7 | 414
Parkinson's disease 7 | 392
Squamous cell carcinoma 7 | 129
Strabismus 7 | 270
Waldenstrons macroglobulinemia 7 | 765
acute myeloid leukemia 7 | 783
adrenocortical carcinoma 7 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
cystic fibrosis 7 | 1,696
pancreatic cancer 7 | 2,398
Cerebrovascular disease 6 | 238
Fever 6 | 138
Isolated cases 6 | 72
Liver Cirrhosis 6 | 181
Liver Cirrhosis, Experimental 6 | 769
Mental Depression 6 | 333
Stomach Neoplasms 6 | 300
acute quadriplegic myopathy 6 | 1,158
gastric carcinoma 6 | 807
medulloblastoma 6 | 720

Tissue

Endocrine System 76 | 18,159
Blood and immune system 75 | 16,909
Digestive Tract 75 | 17,369
Male tissues 75 | 17,142
Cardiovascular System 74 | 15,192
Female tissues 74 | 17,400
Liver and Pancreas 74 | 16,750
Nervous System 74 | 16,725
Respiratory system 74 | 16,393
Skin and soft tissues 74 | 17,230
Urinary Tract 74 | 16,678

Target Family

Non-IDG 28 | 12,091
Enzyme 19 | 4,145
Transcription Factor 17 | 1,400
Kinase 8 | 634
Epigenetic 4 | 242

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Numb-like protein NUMBL Tbio Non-IDG -2.50313 317.9 171
Four and a half LIM domains protein 1 FHL1 Tbio Non-IDG -2.46134 291.4 312
Biogenesis of lysosome-related organelles complex 1 subunit 1 BLOC1S1 Tbio Non-IDG -1.17005 16.2 49
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.44791 277.6 405
Contactin-1 CNTN1 Tbio Non-IDG -1.93017 87.6 211
Delta-like protein 3 DLL3 Tbio Non-IDG -1.68978 48.6 214
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.08501 97.6 139
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.80290 601.6 434
Msx2-interacting protein SPEN Tbio Non-IDG -2.94650 839.8 43