Development Level

Tchem 47 | 1,598
Tbio 21 | 11,445
Tclin 17 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased total body fat amoun... 4 | 207
abnormal gait 3 | 69
decreased body weight 3 | 161
decreased vertical activity 3 | 208
abnormal behavior 2 | 298
abnormal lens morphology 2 | 81
decreased circulating glucose ... 2 | 126
embryonic lethality prior to t... 2 | 278
increased heart rate 2 | 23
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
shortened RR interval 2 | 17
thrombocytopenia 2 | 56
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased grip strength 1 | 41
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
polycystic kidney 1 | 15

Disease

Cancer 72 | 2,499
Carcinoma 69 | 11,493
osteosarcoma 59 | 7,950
ovarian cancer 59 | 8,520
lung cancer 48 | 4,740
glioblastoma 44 | 5,792
medulloblastoma, large-cell 39 | 6,241
psoriasis 37 | 6,694
Breast cancer 33 | 3,578
atypical teratoid / rhabdoid tumor 33 | 5,112
ependymoma 29 | 4,679
Kidney cancer 28 | 2,613
Rheumatoid arthritis 25 | 1,191
lung carcinoma 25 | 2,843
diabetes mellitus 24 | 1,728
subependymal giant cell astrocytoma 24 | 2,287
group 3 medulloblastoma 23 | 4,104
adult high grade glioma 21 | 3,801
non-small cell lung cancer 21 | 2,890
Pick disease 20 | 1,894
Schizophrenia 20 | 1,160
group 4 medulloblastoma 20 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
invasive ductal carcinoma 20 | 2,951
malignant mesothelioma 20 | 3,232
Astrocytoma, Pilocytic 19 | 3,081
Multiple myeloma 19 | 1,332
astrocytoma 19 | 1,146
lung adenocarcinoma 18 | 2,716
oligodendroglioma 18 | 2,850
pancreatic cancer 18 | 2,398
tuberculosis 18 | 2,010
Vascular disease 17 | 319
interstitial cystitis 17 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
pituitary cancer 17 | 1,972
ulcerative colitis 17 | 1,819
Breast Neoplasms 16 | 445
Mammary Neoplasms 16 | 425
Arthritis 15 | 290
Obesity 15 | 678
primitive neuroectodermal tumor 15 | 3,035
Alzheimer's disease 14 | 658
astrocytic glioma 14 | 2,597
colon cancer 14 | 1,478
dermatomyositis 14 | 966
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
juvenile dermatomyositis 14 | 1,187
Bipolar Disorder 13 | 666
Carcinoma, Hepatocellular 13 | 228
Liver carcinoma 13 | 240
Neoplasm Metastasis 13 | 168
Prostatic Neoplasms 13 | 495
Short stature 13 | 531
Stomach Neoplasms 13 | 300
Waldenstrons macroglobulinemia 13 | 765
acute quadriplegic myopathy 13 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Asthma 12 | 385
Carcinoma, Squamous Cell 12 | 110
Depressive disorder 12 | 409
Hypoplastic mandible condyle 12 | 275
Lung Neoplasms 12 | 232
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Orbital separation excessive 12 | 244
Parkinson's disease 12 | 392
Squamous cell carcinoma 12 | 129
Blepharoptosis 11 | 231
Brain Ischemia 11 | 110
Frontal bossing 11 | 157
Intellectual disability 11 | 1,016
Mammary Neoplasms, Experimental 11 | 154
Muscle hypotonia 11 | 571
adrenocortical carcinoma 11 | 1,428
cutaneous lupus erythematosus 11 | 1,057
ductal carcinoma in situ 11 | 1,745
Autosomal recessive predisposition 10 | 1,442
Byzanthine arch palate 10 | 194
Cell Transformation, Neoplastic 10 | 97
Cryptorchidism 10 | 296
Downward slant of palpebral fissure 10 | 158
Dull intelligence 10 | 645
Heart disease 10 | 306
Hypertension 10 | 396
Inflammatory bowel disease 10 | 151
Kidney disease 10 | 430
Liver Cirrhosis, Experimental 10 | 769
Low intelligence 10 | 645
Melanoma 10 | 711
Mental Depression 10 | 333
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Multiple Sclerosis 10 | 540
Poor school performance 10 | 645
Renal Cell Carcinoma 10 | 214
Seizures 10 | 596
acute myeloid leukemia 10 | 783
breast carcinoma 10 | 1,638
cystic fibrosis 10 | 1,696

Tissue

Digestive Tract 85 | 17,369
Endocrine System 85 | 18,159
Female tissues 85 | 17,400
Liver and Pancreas 85 | 16,750
Male tissues 85 | 17,142
Skin and soft tissues 85 | 17,230
Urinary Tract 85 | 16,678
Blood and immune system 84 | 16,909
Cardiovascular System 84 | 15,192
Nervous System 84 | 16,725
Respiratory system 84 | 16,393

Target Family

Kinase 35 | 634
Non-IDG 23 | 12,091
Transcription Factor 13 | 1,400
Enzyme 9 | 4,145
Epigenetic 4 | 242
Nuclear Receptor 1 | 48

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
E3 SUMO-protein ligase PIAS3 PIAS3 Tbio Transcription Factor -1.74449 53.4 174
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.97780 974.9 1992
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Forkhead box protein O4 FOXO4 Tbio Transcription Factor -2.43923 278.0 720