Development Level

Tchem 28 | 1,598
Tbio 16 | 11,445
Tclin 15 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased body weight 4 | 161
decreased total body fat amoun... 4 | 207
abnormal gait 3 | 69
increased neutrophil cell numb... 3 | 46
increased total body fat amoun... 3 | 134
abnormal retina morphology 2 | 71
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
increased monocyte cell number 2 | 63
preweaning lethality, incomple... 2 | 499
thrombocytopenia 2 | 56
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal maxilla morphology 1 | 17
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
female infertility 1 | 60
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased heart left ventricle... 1 | 4
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
mammalian phenotype 1 | 17
short tibia 1 | 97

Disease

Carcinoma 47 | 11,493
Cancer 44 | 2,499
osteosarcoma 42 | 7,950
ovarian cancer 38 | 8,520
medulloblastoma, large-cell 31 | 6,241
lung cancer 30 | 4,740
glioblastoma 29 | 5,792
psoriasis 25 | 6,694
atypical teratoid / rhabdoid tumor 19 | 5,112
lung carcinoma 18 | 2,843
subependymal giant cell astrocytoma 18 | 2,287
Kidney cancer 17 | 2,613
Rheumatoid arthritis 16 | 1,191
diabetes mellitus 16 | 1,728
ependymoma 16 | 4,679
group 4 medulloblastoma 16 | 1,855
invasive ductal carcinoma 16 | 2,951
tuberculosis 16 | 2,010
Breast cancer 15 | 3,578
astrocytoma 15 | 1,146
Arthritis 14 | 290
Schizophrenia 14 | 1,160
Vascular disease 14 | 319
group 3 medulloblastoma 14 | 4,104
interstitial cystitis 14 | 2,312
Multiple myeloma 13 | 1,332
adult high grade glioma 13 | 3,801
malignant mesothelioma 13 | 3,232
non-small cell lung cancer 13 | 2,890
oligodendroglioma 13 | 2,850
primary Sjogren syndrome 13 | 735
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
lung adenocarcinoma 12 | 2,716
Asthma 11 | 385
Astrocytoma, Pilocytic 11 | 3,081
Liver Cirrhosis, Experimental 11 | 769
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
Alzheimer's disease 10 | 658
Breast Neoplasms 10 | 445
Mammary Neoplasms 10 | 425
Short stature 10 | 531
cutaneous lupus erythematosus 10 | 1,057
dermatomyositis 10 | 966
juvenile dermatomyositis 10 | 1,187
pancreatic cancer 10 | 2,398
primitive neuroectodermal tumor 10 | 3,035
Bipolar Disorder 9 | 666
Blepharoptosis 9 | 231
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Lung Neoplasms 9 | 232
Lung disease 9 | 142
Mental and motor retardation 9 | 608
Orbital separation excessive 9 | 244
Pick disease 9 | 1,894
Stomach Neoplasms 9 | 300
astrocytic glioma 9 | 2,597
cystic fibrosis 9 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
ulcerative colitis 9 | 1,819
Anemia 8 | 365
Inflammatory bowel disease 8 | 151
Liver Neoplasms, Experimental 8 | 59
Muscle hypotonia 8 | 571
Obesity 8 | 678
Waldenstrons macroglobulinemia 8 | 765
adrenocortical carcinoma 8 | 1,428
breast carcinoma 8 | 1,638
pituitary cancer 8 | 1,972
Brain Ischemia 7 | 110
Byzanthine arch palate 7 | 194
Carcinoma, Squamous Cell 7 | 110
Concave bridge of nose 7 | 195
Delayed bone age 7 | 136
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Downward slant of palpebral fissure 7 | 158
Frontal bossing 7 | 157
Heart disease 7 | 306
Kidney disease 7 | 430
Melanoma 7 | 711
Multiple Sclerosis 7 | 540
Prostatic Neoplasms 7 | 495
Squamous cell carcinoma 7 | 129
colon cancer 7 | 1,478
ductal carcinoma in situ 7 | 1,745
Acquired scoliosis 6 | 281
Congenital Epicanthus 6 | 177
Curvature of spine 6 | 282
Dull intelligence 6 | 645
Hypoplastic mandible condyle 6 | 275
Immune system cancer 6 | 140
Low intelligence 6 | 645
Mental deficiency 6 | 645
Pectus excavatum 6 | 100
Poor school performance 6 | 645
Short neck 6 | 140
Strabismus 6 | 270
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
pediatric high grade glioma 6 | 1,064

Tissue

Blood and immune system 57 | 16,909
Cardiovascular System 57 | 15,192
Digestive Tract 57 | 17,369
Endocrine System 57 | 18,159
Female tissues 57 | 17,400
Liver and Pancreas 57 | 16,750
Male tissues 57 | 17,142
Nervous System 57 | 16,725
Respiratory system 57 | 16,393
Skin and soft tissues 57 | 17,230
Urinary Tract 57 | 16,678

Target Family

Non-IDG 22 | 12,091
Kinase 20 | 634
Transcription Factor 10 | 1,400
Enzyme 7 | 4,145

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Transcription factor SOX-4 SOX4 Tbio Transcription Factor -2.22104 164.2 211
Ribosomal protein S6 kinase alpha-1 RPS6KA1 Tchem Kinase -2.57872 338.0 1158
Interleukin-5 IL5 Tclin Non-IDG -3.45852 2701.9 571
Cytosolic phospholipase A2 PLA2G4A Tchem Enzyme -2.68316 506.7 274