Development Level

Tbio 50 | 11,445
Tchem 35 | 1,598
Tclin 19 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased body weight 5 | 161
decreased total body fat amoun... 4 | 207
preweaning lethality, incomple... 4 | 499
abnormal gait 3 | 69
abnormal bone structure 2 | 187
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased hemoglobin content 2 | 68
decreased startle reflex 2 | 75
increased blood urea nitrogen ... 2 | 48
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating glycerol... 1 | 16
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hypoactivity 1 | 132
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased body temperature 1 | 9
increased circulating LDL chol... 1 | 13
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased heart left ventricle... 1 | 4
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased vertical activity 1 | 24
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 86 | 11,493
osteosarcoma 71 | 7,950
ovarian cancer 69 | 8,520
Cancer 67 | 2,499
glioblastoma 46 | 5,792
medulloblastoma, large-cell 44 | 6,241
lung cancer 42 | 4,740
psoriasis 42 | 6,694
atypical teratoid / rhabdoid tumor 37 | 5,112
Breast cancer 35 | 3,578
Kidney cancer 31 | 2,613
ependymoma 29 | 4,679
group 3 medulloblastoma 27 | 4,104
interstitial cystitis 27 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
adult high grade glioma 26 | 3,801
lung carcinoma 26 | 2,843
invasive ductal carcinoma 25 | 2,951
tuberculosis 25 | 2,010
group 4 medulloblastoma 24 | 1,855
subependymal giant cell astrocytoma 24 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
non-small cell lung cancer 23 | 2,890
ulcerative colitis 23 | 1,819
diabetes mellitus 21 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
lung adenocarcinoma 21 | 2,716
malignant mesothelioma 21 | 3,232
pancreatic cancer 21 | 2,398
primary Sjogren syndrome 21 | 735
primitive neuroectodermal tumor 21 | 3,035
Astrocytoma, Pilocytic 20 | 3,081
Schizophrenia 20 | 1,160
juvenile dermatomyositis 20 | 1,187
Rheumatoid arthritis 19 | 1,191
astrocytic glioma 19 | 2,597
astrocytoma 19 | 1,146
oligodendroglioma 18 | 2,850
cutaneous lupus erythematosus 17 | 1,057
Breast Neoplasms 16 | 445
Mammary Neoplasms 16 | 425
Waldenstrons macroglobulinemia 16 | 765
Vascular disease 15 | 319
ductal carcinoma in situ 15 | 1,745
Liver Cirrhosis, Experimental 14 | 769
Pick disease 14 | 1,894
Stomach Neoplasms 14 | 300
colon cancer 14 | 1,478
dermatomyositis 14 | 966
Alzheimer's disease 13 | 658
Lung Neoplasms 13 | 232
breast carcinoma 13 | 1,638
pituitary cancer 13 | 1,972
Arthritis 12 | 290
Melanoma 12 | 711
Multiple myeloma 12 | 1,332
Obesity 12 | 678
Renal Cell Carcinoma 12 | 214
Short stature 12 | 531
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Anemia 11 | 365
Bipolar Disorder 11 | 666
Cognitive delay 11 | 608
Fatigue 11 | 182
Global developmental delay 11 | 608
Heart disease 11 | 306
Mental and motor retardation 11 | 608
Multiple Sclerosis 11 | 540
Orbital separation excessive 11 | 244
cystic fibrosis 11 | 1,696
spina bifida 11 | 1,074
Autosomal recessive predisposition 10 | 1,442
Blastic phase chronic myeloid leukemia 10 | 58
Blepharoptosis 10 | 231
Byzanthine arch palate 10 | 194
Chronic Myelocytic Leukemia Accelerated Phase 10 | 59
Downward slant of palpebral fissure 10 | 158
Fever 10 | 138
Intellectual disability 10 | 1,016
Neurofibromatosis 10 | 40
Parkinson's disease 10 | 392
Prostatic Neoplasms 10 | 495
acute myeloid leukemia 10 | 783
gastric carcinoma 10 | 807
primary pancreatic ductal adenocarcinoma 10 | 1,109
Acquired scoliosis 9 | 281
Congenital Epicanthus 9 | 177
Curvature of spine 9 | 282
Dull intelligence 9 | 645
Hypoplastic mandible condyle 9 | 275
Low intelligence 9 | 645
Mandibular hypoplasia 9 | 275
Mental deficiency 9 | 645
Micrognathism 9 | 275
Muscle hypotonia 9 | 571
Poor school performance 9 | 645
acute quadriplegic myopathy 9 | 1,158
nasopharyngeal carcinoma 9 | 1,058
pancreatic carcinoma 9 | 562
progressive supranuclear palsy 9 | 676

Tissue

Blood and immune system 103 | 16,909
Cardiovascular System 103 | 15,192
Digestive Tract 103 | 17,369
Endocrine System 103 | 18,159
Female tissues 103 | 17,400
Liver and Pancreas 103 | 16,750
Male tissues 103 | 17,142
Respiratory system 103 | 16,393
Skin and soft tissues 103 | 17,230
Urinary Tract 103 | 16,678
Nervous System 102 | 16,725

Target Family

Non-IDG 41 | 12,091
Kinase 35 | 634
Enzyme 16 | 4,145
Transcription Factor 11 | 1,400
Epigenetic 1 | 242

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Suppressor of cytokine signaling 4 SOCS4 Tbio Non-IDG -1.22763 14.8 224
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Megakaryocyte-associated tyrosine-protein kinase MATK Tbio Kinase -2.98596 792.3 265
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GRB2-related adapter protein GRAP Tbio Non-IDG -1.51362 31.8 124
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365