Development Level

Tbio 144 | 11,445
Tchem 56 | 1,598
Tclin 17 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 24 | 979
preweaning lethality, incomple... 13 | 499
abnormal bone structure 8 | 187
abnormal behavior 7 | 298
decreased body length 7 | 101
decreased total body fat amoun... 7 | 207
abnormal heart morphology 6 | 162
abnormal retina morphology 6 | 71
decreased bone mineral content 6 | 151
decreased body weight 5 | 161
decreased bone mineral density 5 | 126
decreased lean body mass 5 | 135
embryonic lethality prior to t... 5 | 278
enlarged heart 5 | 210
increased heart weight 5 | 62
abnormal embryo size 4 | 220
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased prepulse inhibition 4 | 82
edema 4 | 59
hyperactivity 4 | 148
hypoactivity 4 | 132
increased lean body mass 4 | 172
increased mean corpuscular vol... 4 | 92
abnormal testis morphology 3 | 43
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased fasted circulating g... 3 | 65
decreased lymphocyte cell numb... 3 | 83
decreased startle reflex 3 | 75
embryonic lethality prior to o... 3 | 239
increased bone mineral density 3 | 72
increased or absent threshold ... 3 | 101
male infertility 3 | 123
thrombocytopenia 3 | 56
abnormal coat-hair pigmentatio... 2 | 64
abnormal eye morphology 2 | 68
abnormal head morphology 2 | 10
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
abnormal startle reflex 2 | 15
abnormal tooth morphology 2 | 24
decreased circulating LDL chol... 2 | 38
decreased circulating total pr... 2 | 49
decreased erythrocyte cell num... 2 | 62
decreased mean corpuscular hem... 2 | 31
decreased red blood cell distr... 2 | 41
enlarged kidney 2 | 14
enlarged spleen 2 | 41
increased body length 2 | 32
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating phosphat... 2 | 26
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
mammalian phenotype 2 | 17
microphthalmia 2 | 26
small testis 2 | 58
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal spleen morphology 1 | 55
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged lymph nodes 1 | 37
impaired pupillary reflex 1 | 26
increased cardiac muscle contr... 1 | 8
increased circulating calcium ... 1 | 34
increased circulating fructosa... 1 | 13
increased circulating magnesiu... 1 | 10
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 164 | 11,493
ovarian cancer 157 | 8,520
osteosarcoma 136 | 7,950
Cancer 131 | 2,499
glioblastoma 120 | 5,792
psoriasis 108 | 6,694
medulloblastoma, large-cell 97 | 6,241
atypical teratoid / rhabdoid tumor 94 | 5,112
lung cancer 90 | 4,740
Breast cancer 79 | 3,578
ependymoma 78 | 4,679
group 3 medulloblastoma 68 | 4,104
adult high grade glioma 66 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 60 | 3,291
Kidney cancer 58 | 2,613
malignant mesothelioma 57 | 3,232
Astrocytoma, Pilocytic 55 | 3,081
non-small cell lung cancer 53 | 2,890
oligodendroglioma 49 | 2,850
primitive neuroectodermal tumor 49 | 3,035
invasive ductal carcinoma 47 | 2,951
subependymal giant cell astrocytoma 47 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 46 | 2,989
lung adenocarcinoma 46 | 2,716
pancreatic cancer 46 | 2,398
astrocytic glioma 43 | 2,597
diabetes mellitus 42 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
tuberculosis 39 | 2,010
Multiple myeloma 38 | 1,332
lung carcinoma 38 | 2,843
Pick disease 36 | 1,894
Schizophrenia 36 | 1,160
ductal carcinoma in situ 35 | 1,745
colon cancer 34 | 1,478
Rheumatoid arthritis 33 | 1,191
group 4 medulloblastoma 33 | 1,855
juvenile dermatomyositis 32 | 1,187
ulcerative colitis 32 | 1,819
acute quadriplegic myopathy 31 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
primary pancreatic ductal adenocarcinoma 31 | 1,109
pituitary cancer 30 | 1,972
adrenocortical carcinoma 29 | 1,428
astrocytoma 29 | 1,146
breast carcinoma 29 | 1,638
Vascular disease 28 | 319
Waldenstrons macroglobulinemia 28 | 765
dermatomyositis 28 | 966
Breast Neoplasms 26 | 445
Intellectual disability 26 | 1,016
Lung Neoplasms 25 | 232
Prostatic Neoplasms 25 | 495
acute myeloid leukemia 25 | 783
cystic fibrosis 25 | 1,696
Stomach Neoplasms 24 | 300
Epilepsy 23 | 792
Liver Cirrhosis, Experimental 23 | 769
Mammary Neoplasms 23 | 425
Muscle hypotonia 21 | 571
Osteoporosis 21 | 363
interstitial cystitis 21 | 2,312
Carcinoma, Hepatocellular 20 | 228
Dull intelligence 20 | 645
Hypertensive disease 20 | 292
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Neoplasm Metastasis 20 | 168
Orbital separation excessive 20 | 244
Poor school performance 20 | 645
pediatric high grade glioma 20 | 1,064
Acquired scoliosis 19 | 281
Curvature of spine 19 | 282
Endometriosis 19 | 540
Kidney disease 19 | 430
Liver carcinoma 19 | 240
Short stature 19 | 531
Arthritis 18 | 290
Hypertension 18 | 396
Hypoplastic mandible condyle 18 | 275
Mandibular hypoplasia 18 | 275
Micrognathism 18 | 275
Seizures 18 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 510
Neoplasm Invasiveness 17 | 161
gastric cancer 17 | 459
medulloblastoma 17 | 720
Bipolar Disorder 16 | 666
Cell Transformation, Neoplastic 16 | 97
Down syndrome 16 | 499
Obesity 16 | 678
Ovarian Neoplasms 16 | 102
Parkinson's disease 16 | 392
Squamous cell carcinoma 16 | 129
Amyotrophic lateral sclerosis 15 | 451
Byzanthine arch palate 15 | 194
Carcinoma, Squamous Cell 15 | 110
Colorectal Neoplasms 15 | 243
ovarian neoplasm 15 | 99

Tissue

Digestive Tract 219 | 17,369
Endocrine System 219 | 18,159
Blood and immune system 218 | 16,909
Nervous System 218 | 16,725
Skin and soft tissues 218 | 17,230
Female tissues 217 | 17,400
Liver and Pancreas 217 | 16,750
Male tissues 217 | 17,142
Respiratory system 217 | 16,393
Urinary Tract 217 | 16,678
Cardiovascular System 213 | 15,192

Target Family

Non-IDG 85 | 12,091
Transcription Factor 47 | 1,400
Kinase 41 | 634
Enzyme 36 | 4,145
Epigenetic 7 | 242
Nuclear Receptor 4 | 48

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
Anaphase-promoting complex subunit 7 ANAPC7 Tbio Enzyme -0.17118 1.40 73
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
Mediator of RNA polymerase II transcription subunit 15 MED15 Tbio Enzyme -1.60315 40.6 144
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448