Development Level

Tchem 33 | 1,598
Tbio 31 | 11,445
Tclin 17 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal gait 3 | 69
increased mean corpuscular hem... 3 | 96
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
decreased total body fat amoun... 2 | 207
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
increased neutrophil cell numb... 2 | 46
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal colon morphology 1 | 3
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
enlarged heart 1 | 210
female infertility 1 | 60
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased heart left ventricle... 1 | 4
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
limb grasping 1 | 41

Disease

Cancer 68 | 2,499
Carcinoma 64 | 11,493
ovarian cancer 58 | 8,520
osteosarcoma 53 | 7,950
medulloblastoma, large-cell 45 | 6,241
psoriasis 44 | 6,694
lung cancer 41 | 4,740
glioblastoma 39 | 5,792
atypical teratoid / rhabdoid tumor 32 | 5,112
Breast cancer 29 | 3,578
adult high grade glioma 24 | 3,801
Schizophrenia 23 | 1,160
ependymoma 23 | 4,679
group 3 medulloblastoma 23 | 4,104
diabetes mellitus 22 | 1,728
malignant mesothelioma 22 | 3,232
tuberculosis 21 | 2,010
Astrocytoma, Pilocytic 20 | 3,081
Kidney cancer 19 | 2,613
Multiple myeloma 19 | 1,332
Rheumatoid arthritis 19 | 1,191
invasive ductal carcinoma 19 | 2,951
subependymal giant cell astrocytoma 19 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
juvenile dermatomyositis 18 | 1,187
non-small cell lung cancer 18 | 2,890
primitive neuroectodermal tumor 18 | 3,035
Vascular disease 17 | 319
group 4 medulloblastoma 17 | 1,855
pancreatic cancer 17 | 2,398
interstitial cystitis 16 | 2,312
primary Sjogren syndrome 16 | 735
ulcerative colitis 16 | 1,819
lung adenocarcinoma 15 | 2,716
lung carcinoma 15 | 2,843
oligodendroglioma 15 | 2,850
Alzheimer's disease 14 | 658
Breast Neoplasms 14 | 445
Mammary Neoplasms 14 | 425
Multiple Sclerosis 14 | 540
Obesity 14 | 678
astrocytoma 14 | 1,146
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Arthritis 13 | 290
Asthma 13 | 385
Prostatic Neoplasms 13 | 495
pituitary cancer 13 | 1,972
Melanoma 12 | 711
Pick disease 12 | 1,894
colon cancer 12 | 1,478
cutaneous lupus erythematosus 12 | 1,057
Bipolar Disorder 11 | 666
Carcinoma, Hepatocellular 11 | 228
Hyperglycemia 11 | 137
Liver carcinoma 11 | 240
breast carcinoma 11 | 1,638
Anemia 10 | 365
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Inflammatory bowel disease 10 | 151
Lung Neoplasms 10 | 232
Major Depressive Disorder 10 | 301
Mental and motor retardation 10 | 608
Orbital separation excessive 10 | 244
Short stature 10 | 531
Stomach Neoplasms 10 | 300
active ulcerative colitis 10 | 764
astrocytic glioma 10 | 2,597
dermatomyositis 10 | 966
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
Atopic dermatitis 9 | 952
Hypertension 9 | 396
Kidney disease 9 | 430
Liver Cirrhosis, Experimental 9 | 769
Unipolar Depression 9 | 250
Waldenstrons macroglobulinemia 9 | 765
adrenocortical carcinoma 9 | 1,428
cystic fibrosis 9 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Acquired scoliosis 8 | 281
Blepharoptosis 8 | 231
Brain Ischemia 8 | 110
Byzanthine arch palate 8 | 194
Concave bridge of nose 8 | 195
Curvature of spine 8 | 282
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Depressive disorder 8 | 409
Downward slant of palpebral fissure 8 | 158
Hypertensive disease 8 | 292
Immune system cancer 8 | 140
Intellectual disability 8 | 1,016
Pectus excavatum 8 | 100
Reperfusion Injury 8 | 86
Splenomegaly 8 | 190
active Crohn's disease 8 | 922
acute quadriplegic myopathy 8 | 1,158
pancreatic carcinoma 8 | 562
primary pancreatic ductal adenocarcinoma 8 | 1,109

Tissue

Blood and immune system 81 | 16,909
Digestive Tract 81 | 17,369
Endocrine System 80 | 18,159
Female tissues 80 | 17,400
Liver and Pancreas 80 | 16,750
Male tissues 80 | 17,142
Skin and soft tissues 80 | 17,230
Nervous System 79 | 16,725
Respiratory system 79 | 16,393
Urinary Tract 79 | 16,678
Cardiovascular System 78 | 15,192

Target Family

Non-IDG 31 | 12,091
Kinase 27 | 634
Transcription Factor 15 | 1,400
Enzyme 7 | 4,145
Nuclear Receptor 1 | 48

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Eukaryotic translation initiation factor 3 subunit B EIF3B Tbio Non-IDG -1.83618 70.5 84
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
40S ribosomal protein S6 RPS6 Tbio Non-IDG -2.76789 501.6 920
Protein C-ets-1 ETS1 Tbio Transcription Factor -2.89500 760.0 463
SH2 domain-containing adapter protein B SHB Tbio Non-IDG -2.19060 169.7 209
Telomerase reverse transcriptase TERT Tchem Enzyme -3.56910 3506.4 643