Development Level

Tchem 48 | 1,598
Tbio 31 | 11,445
Tclin 19 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 5 | 298
decreased body weight 4 | 161
increased circulating alkaline... 4 | 122
preweaning lethality, incomple... 4 | 499
abnormal gait 3 | 69
decreased circulating choleste... 3 | 93
decreased leukocyte cell numbe... 3 | 73
decreased total body fat amoun... 3 | 207
increased circulating iron lev... 3 | 30
increased mean platelet volume 3 | 45
increased total body fat amoun... 3 | 134
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating glucose ... 2 | 126
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
enlarged spleen 2 | 41
impaired righting response 2 | 26
increased circulating alanine ... 2 | 13
increased circulating aspartat... 2 | 15
increased circulating bilirubi... 2 | 16
increased circulating glucose ... 2 | 24
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
tremors 2 | 39
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
abnormal joint morphology 1 | 23
abnormal locomotor behavior 1 | 24
abnormal optic disc morphology 1 | 10
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
absent vibrissae 1 | 12
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased mature B cell number 1 | 7
decreased monocyte cell number 1 | 8
enlarged lymph nodes 1 | 37
enlarged thymus 1 | 5
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased T cell number 1 | 6
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased glycosylated hemoglo... 1 | 1
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
limb grasping 1 | 41
polycystic kidney 1 | 15
shortened RR interval 1 | 17
small seminal vesicle 1 | 10
trunk curl 1 | 16

Disease

Cancer 75 | 2,499
Carcinoma 75 | 11,493
osteosarcoma 64 | 7,950
ovarian cancer 61 | 8,520
glioblastoma 50 | 5,792
psoriasis 50 | 6,694
medulloblastoma, large-cell 47 | 6,241
lung cancer 43 | 4,740
atypical teratoid / rhabdoid tumor 41 | 5,112
ependymoma 38 | 4,679
Breast cancer 34 | 3,578
Kidney cancer 33 | 2,613
diabetes mellitus 33 | 1,728
adult high grade glioma 30 | 3,801
invasive ductal carcinoma 27 | 2,951
Obesity 26 | 678
group 3 medulloblastoma 26 | 4,104
Rheumatoid arthritis 25 | 1,191
group 4 medulloblastoma 25 | 1,855
lung adenocarcinoma 24 | 2,716
tuberculosis 24 | 2,010
Astrocytoma, Pilocytic 23 | 3,081
Schizophrenia 23 | 1,160
oligodendroglioma 23 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
non-small cell lung cancer 22 | 2,890
Vascular disease 21 | 319
breast carcinoma 21 | 1,638
malignant mesothelioma 21 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
subependymal giant cell astrocytoma 21 | 2,287
ductal carcinoma in situ 20 | 1,745
Alzheimer's disease 19 | 658
Breast Neoplasms 19 | 445
Mammary Neoplasms 19 | 425
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
ulcerative colitis 19 | 1,819
Hyperglycemia 18 | 137
Pick disease 18 | 1,894
interstitial cystitis 18 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
primitive neuroectodermal tumor 18 | 3,035
Autosomal recessive predisposition 17 | 1,442
Stomach Neoplasms 17 | 300
pancreatic cancer 17 | 2,398
pituitary cancer 17 | 1,972
Arthritis 16 | 290
Carcinoma, Hepatocellular 16 | 228
Liver carcinoma 16 | 240
Prostatic Neoplasms 16 | 495
astrocytic glioma 16 | 2,597
lung carcinoma 16 | 2,843
Bipolar Disorder 15 | 666
Multiple myeloma 15 | 1,332
Short stature 15 | 531
astrocytoma 15 | 1,146
juvenile dermatomyositis 15 | 1,187
Renal Cell Carcinoma 14 | 214
Asthma 13 | 385
Depressive disorder 13 | 409
Heart disease 13 | 306
Hypertension 13 | 396
Hypertensive disease 13 | 292
Intellectual disability 13 | 1,016
colon cancer 13 | 1,478
Hyperinsulinism 12 | 133
Insulin Resistance 12 | 72
Lung Neoplasms 12 | 232
adrenocortical carcinoma 12 | 1,428
cystic fibrosis 12 | 1,696
Adenocarcinoma 11 | 122
Atopic dermatitis 11 | 952
Cell Transformation, Neoplastic 11 | 97
Dull intelligence 11 | 645
Kidney disease 11 | 430
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Neoplasm Invasiveness 11 | 161
Neoplasm Metastasis 11 | 168
Parkinson's disease 11 | 392
Poor school performance 11 | 645
Squamous cell carcinoma 11 | 129
acute quadriplegic myopathy 11 | 1,158
dermatomyositis 11 | 966
Acquired scoliosis 10 | 281
Brain Ischemia 10 | 110
Byzanthine arch palate 10 | 194
Cognitive delay 10 | 608
Curvature of spine 10 | 282
Epilepsy 10 | 792
Global developmental delay 10 | 608
Hypoplastic mandible condyle 10 | 275
Mandibular hypoplasia 10 | 275
Mental and motor retardation 10 | 608
Micrognathism 10 | 275
Seizures 10 | 596
pediatric high grade glioma 10 | 1,064
primary Sjogren syndrome 10 | 735
spina bifida 10 | 1,074

Tissue

Digestive Tract 98 | 17,369
Endocrine System 98 | 18,159
Female tissues 98 | 17,400
Nervous System 98 | 16,725
Skin and soft tissues 98 | 17,230
Blood and immune system 97 | 16,909
Liver and Pancreas 97 | 16,750
Male tissues 97 | 17,142
Urinary Tract 97 | 16,678
Cardiovascular System 96 | 15,192
Respiratory system 96 | 16,393

Target Family

Kinase 40 | 634
Non-IDG 27 | 12,091
Transcription Factor 15 | 1,400
Enzyme 12 | 4,145
Epigenetic 2 | 242
Nuclear Receptor 1 | 48
Transporter 1 | 473

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.97780 974.9 1992
Neuromodulin GAP43 Tbio Non-IDG -2.93905 762.9 597
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631
Suppressor of cytokine signaling 7 SOCS7 Tbio Non-IDG -1.64336 42.5 122
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013