Development Level

Tbio 73 | 11,651
Tchem 36 | 1,388
Tclin 8 | 612
Tdark 1 | 6,593

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 18 | 979
decreased total body fat amoun... 6 | 207
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 6 | 499
decreased body weight 5 | 161
abnormal behavior 4 | 298
abnormal embryo size 4 | 220
abnormal heart morphology 4 | 162
decreased circulating serum al... 4 | 82
decreased vertical activity 4 | 208
increased bone mineral density 4 | 72
increased startle reflex 4 | 112
abnormal retina morphology 3 | 71
decreased body length 3 | 101
decreased circulating choleste... 3 | 93
decreased circulating fructosa... 3 | 30
decreased circulating total pr... 3 | 49
decreased lean body mass 3 | 135
embryonic lethality prior to o... 3 | 239
enlarged heart 3 | 210
increased lean body mass 3 | 172
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal startle reflex 2 | 15
abnormal testis morphology 2 | 43
abnormal vibrissa morphology 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating insulin ... 2 | 76
decreased fasted circulating g... 2 | 65
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased total body fat amoun... 2 | 134
mammalian phenotype 2 | 17
microphthalmia 2 | 26
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
small superior vagus ganglion 2 | 74
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal facial morphology 1 | 17
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal iris morphology 1 | 13
abnormal limb bud morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal tail movements 1 | 12
abnormal vitreous body morphol... 1 | 10
anophthalmia 1 | 33
cataract 1 | 92
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating LDL chol... 1 | 38
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased hemoglobin content 1 | 68
decreased total retina thickne... 1 | 17
edema 1 | 59
female infertility 1 | 60
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
male infertility 1 | 123
pallor 1 | 34

Disease

Carcinoma 98 | 11,493
ovarian cancer 74 | 8,520
osteosarcoma 67 | 7,950
Cancer 65 | 2,499
psoriasis 62 | 6,694
atypical teratoid / rhabdoid tumor 54 | 5,112
glioblastoma 52 | 5,792
ependymoma 49 | 4,679
medulloblastoma, large-cell 49 | 6,241
group 3 medulloblastoma 43 | 4,104
lung cancer 42 | 4,740
Breast cancer 40 | 3,578
primitive neuroectodermal tumor 39 | 3,035
malignant mesothelioma 35 | 3,232
Kidney cancer 33 | 2,613
non-small cell lung cancer 33 | 2,890
interstitial cystitis 32 | 2,312
Astrocytoma, Pilocytic 31 | 3,081
adult high grade glioma 31 | 3,801
lung adenocarcinoma 31 | 2,716
oligodendroglioma 31 | 2,850
astrocytic glioma 30 | 2,597
invasive ductal carcinoma 30 | 2,951
lung carcinoma 29 | 2,843
Schizophrenia 27 | 1,160
breast carcinoma 24 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
pancreatic cancer 23 | 2,398
diabetes mellitus 22 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
ductal carcinoma in situ 21 | 1,745
pituitary cancer 21 | 1,972
Osteoporosis 20 | 363
Pick disease 19 | 1,894
subependymal giant cell astrocytoma 19 | 2,287
tuberculosis 19 | 2,010
cystic fibrosis 18 | 1,696
group 4 medulloblastoma 18 | 1,855
Bipolar Disorder 17 | 666
Breast Neoplasms 17 | 445
Kidney disease 17 | 430
Colorectal Neoplasms 16 | 243
Rheumatoid arthritis 16 | 1,191
Stomach Neoplasms 16 | 300
colon cancer 16 | 1,478
ulcerative colitis 16 | 1,819
Alzheimer's disease 14 | 658
Intellectual disability 14 | 1,016
Mammary Neoplasms 14 | 425
Vascular disease 14 | 319
Autosomal recessive predisposition 13 | 1,442
Depressive disorder 13 | 409
Parkinson's disease 13 | 392
adrenocortical carcinoma 13 | 1,428
pediatric high grade glioma 13 | 1,064
Obesity 12 | 678
acute myeloid leukemia 12 | 783
acute quadriplegic myopathy 12 | 1,158
astrocytoma 12 | 1,146
esophageal adenocarcinoma 12 | 737
juvenile dermatomyositis 12 | 1,187
Hypoplastic mandible condyle 11 | 275
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Orbital separation excessive 11 | 244
Prostatic Neoplasms 11 | 495
cutaneous lupus erythematosus 11 | 1,057
primary pancreatic ductal adenocarcinoma 11 | 1,109
spina bifida 11 | 1,074
Cognitive delay 10 | 608
Colonic Neoplasms 10 | 142
Cryptorchidism 10 | 296
Disease Models, Animal 10 | 155
Dull intelligence 10 | 645
Global developmental delay 10 | 608
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental and motor retardation 10 | 608
Mental deficiency 10 | 645
Poor school performance 10 | 645
Renal Cell Carcinoma 10 | 214
Short stature 10 | 531
Adenoma 9 | 167
Arthritis 9 | 290
Cleft Palate 9 | 271
Heart disease 9 | 306
Lung Neoplasms 9 | 232
Multiple myeloma 9 | 1,332
Neoplasm Invasiveness 9 | 161
Waldenstrons macroglobulinemia 9 | 765
dermatomyositis 9 | 966
medulloblastoma 9 | 720
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Asthma 8 | 385
Duchenne muscular dystrophy 8 | 601
Mental Depression 8 | 333
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
fibroadenoma 8 | 559
gastric carcinoma 8 | 807

Tissue

Endocrine System 116 | 18,159
Female tissues 116 | 17,400
Nervous System 116 | 16,725
Digestive Tract 115 | 17,369
Male tissues 115 | 17,142
Skin and soft tissues 115 | 17,230
Blood and immune system 114 | 16,909
Urinary Tract 113 | 16,678
Liver and Pancreas 111 | 16,750
Respiratory system 111 | 16,393
Cardiovascular System 107 | 15,192

Target Family

Non-IDG 52 | 12,091
Kinase 34 | 634
GPCR 10 | 408
Transcription Factor 9 | 1,400
Enzyme 8 | 4,145
Epigenetic 1 | 242
Ion Channel 1 | 344
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38
Transporter 1 | 473

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol 4-kinase type 2-alpha PI4K2A Tbio Kinase -2.88003 745.1 146
Wnt inhibitory factor 1 WIF1 Tbio Non-IDG -2.11284 143.2 350
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Tyrosine-protein kinase transmembrane receptor ROR2 ROR2 Tbio Kinase -1.88065 80.4 419
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Frizzled-4 FZD4 Tbio GPCR -2.05508 106.8 313
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.71197 390.1 730
Disabled homolog 2 DAB2 Tbio Non-IDG -2.26146 184.8 239