Development Level

Tbio 144 | 11,445
Tchem 81 | 1,598
Tclin 25 | 613
Tdark 8 | 6,588

Collection

Kinase: IDG Consortium (Target... 6 | 125

IMPC Phenotype

preweaning lethality, complete... 24 | 979
embryonic lethality prior to t... 9 | 278
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to o... 7 | 239
abnormal bone structure 6 | 187
decreased total body fat amoun... 6 | 207
abnormal behavior 5 | 298
abnormal embryo size 5 | 220
decreased bone mineral content 5 | 151
decreased vertical activity 5 | 208
increased neutrophil cell numb... 5 | 46
short tibia 5 | 97
abnormal retina morphology 4 | 71
decreased lean body mass 4 | 135
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular vol... 4 | 79
embryonic growth retardation 4 | 106
increased total body fat amoun... 4 | 134
abnormal gait 3 | 69
abnormal skin morphology 3 | 50
cataract 3 | 92
decreased body weight 3 | 161
decreased bone mineral density 3 | 126
decreased circulating alkaline... 3 | 46
decreased leukocyte cell numbe... 3 | 73
enlarged lymph nodes 3 | 37
hypoactivity 3 | 132
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased lean body mass 3 | 172
increased leukocyte cell numbe... 3 | 47
increased monocyte cell number 3 | 63
abnormal bone mineralization 2 | 38
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
abnormal startle reflex 2 | 15
decreased body length 2 | 101
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating sodium l... 2 | 22
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased large unstained cell... 2 | 11
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
edema 2 | 59
enlarged heart 2 | 210
enlarged kidney 2 | 14
enlarged spleen 2 | 41
hyperactivity 2 | 148
impaired righting response 2 | 26
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating free fat... 2 | 20
increased erythrocyte cell num... 2 | 39
increased spleen weight 2 | 10
male infertility 2 | 123
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 23
absent vibrissae 1 | 12
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 195 | 11,493
osteosarcoma 163 | 7,950
ovarian cancer 163 | 8,520
Cancer 113 | 2,499
psoriasis 111 | 6,694
glioblastoma 109 | 5,792
medulloblastoma, large-cell 105 | 6,241
lung cancer 102 | 4,740
atypical teratoid / rhabdoid tumor 80 | 5,112
ependymoma 77 | 4,679
lung carcinoma 76 | 2,843
Breast cancer 69 | 3,578
interstitial cystitis 69 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,291
malignant mesothelioma 65 | 3,232
non-small cell lung cancer 65 | 2,890
invasive ductal carcinoma 64 | 2,951
oligodendroglioma 64 | 2,850
Kidney cancer 62 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 62 | 2,989
subependymal giant cell astrocytoma 60 | 2,287
adult high grade glioma 57 | 3,801
group 3 medulloblastoma 57 | 4,104
Astrocytoma, Pilocytic 55 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 52 | 2,955
pancreatic cancer 50 | 2,398
ulcerative colitis 49 | 1,819
primitive neuroectodermal tumor 48 | 3,035
diabetes mellitus 46 | 1,728
Multiple myeloma 45 | 1,332
tuberculosis 45 | 2,010
astrocytoma 43 | 1,146
cutaneous lupus erythematosus 43 | 1,057
group 4 medulloblastoma 43 | 1,855
lung adenocarcinoma 43 | 2,716
Pick disease 42 | 1,894
astrocytic glioma 42 | 2,597
Rheumatoid arthritis 41 | 1,191
primary Sjogren syndrome 41 | 735
Waldenstrons macroglobulinemia 39 | 765
juvenile dermatomyositis 37 | 1,187
breast carcinoma 34 | 1,638
Autosomal recessive predisposition 32 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,962
Schizophrenia 31 | 1,160
dermatomyositis 31 | 966
spina bifida 31 | 1,074
colon cancer 29 | 1,478
cystic fibrosis 29 | 1,696
primary pancreatic ductal adenocarcinoma 29 | 1,109
acute quadriplegic myopathy 28 | 1,158
ductal carcinoma in situ 27 | 1,745
Liver Cirrhosis, Experimental 26 | 769
Alzheimer's disease 24 | 658
acute myeloid leukemia 24 | 783
pediatric high grade glioma 23 | 1,064
pituitary cancer 23 | 1,972
Bipolar Disorder 22 | 666
Arthritis 21 | 290
Immunologic Deficiency Syndromes 21 | 113
Intellectual disability 20 | 1,016
gastric carcinoma 20 | 807
Duchenne muscular dystrophy 19 | 601
Breast Neoplasms 18 | 445
Vascular disease 18 | 319
adrenocortical carcinoma 18 | 1,428
esophageal adenocarcinoma 18 | 737
Chronic Lymphocytic Leukemia 16 | 262
Kidney disease 16 | 430
Lung Neoplasms 16 | 232
Mammary Neoplasms 16 | 425
Anemia 15 | 365
Asthma 15 | 385
Down syndrome 15 | 499
Muscle hypotonia 15 | 571
Obesity 15 | 678
Osteoporosis 15 | 363
Parkinson's disease 15 | 392
Arthritis, Rheumatoid 14 | 174
Dull intelligence 14 | 645
Hypersensitivity reaction type II disease 14 | 253
Liver cancer 14 | 604
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
Renal Cell Carcinoma 14 | 214
Short stature 14 | 531
nasopharyngeal carcinoma 14 | 1,058
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Hepatomegaly 13 | 285
Hypertensive disease 13 | 292
Lung disease 13 | 142
Mental and motor retardation 13 | 608
Multiple Sclerosis 13 | 540
Myocardial Ischemia 13 | 169
Prostatic Neoplasms 13 | 495
active Crohn's disease 13 | 922
active ulcerative colitis 13 | 764

Tissue

Blood and immune system 256 | 16,909
Digestive Tract 256 | 17,369
Endocrine System 256 | 18,159
Female tissues 256 | 17,400
Liver and Pancreas 256 | 16,750
Male tissues 256 | 17,142
Respiratory system 256 | 16,393
Skin and soft tissues 256 | 17,230
Urinary Tract 256 | 16,678
Cardiovascular System 255 | 15,192
Nervous System 250 | 16,725

Target Family

Non-IDG 132 | 12,091
Kinase 52 | 634
Enzyme 51 | 4,145
Transcription Factor 16 | 1,400
Epigenetic 3 | 242
Transporter 2 | 473
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Caskin-2 CASKIN2 Tdark Non-IDG -0.21450 1.97 118
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
CD2-associated protein CD2AP Tbio Non-IDG -3.44533 2735.9 82
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Tumor susceptibility gene 101 protein TSG101 Tbio Non-IDG -2.47780 298.9 332
Zinc finger protein 404 ZNF404 Tdark Transcription Factor 0.18 0.73 39
Serine/threonine-protein kinase PRP4 homolog PRPF4B Tchem Kinase -1.17233 14.7 144
Signaling threshold-regulating transmembrane adapter 1 SIT1 Tdark Non-IDG -0.68059 3.19 152
Dual specificity tyrosine-phosphorylation-regulated kinase 1B DYRK1B Tchem Kinase -1.63295 52.7 289