Development Level

Tbio 315 | 11,651
Tchem 117 | 1,388
Tclin 30 | 612
Tdark 10 | 6,593

Collection

RFA-RM-18-021 7 | 328
Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 35 | 979
preweaning lethality, incomple... 19 | 499
abnormal bone structure 12 | 187
decreased total body fat amoun... 12 | 207
decreased body weight 10 | 161
abnormal behavior 7 | 298
abnormal retina morphology 7 | 71
decreased bone mineral density 7 | 126
hypoactivity 7 | 132
increased circulating alkaline... 7 | 122
increased lean body mass 7 | 172
decreased bone mineral content 6 | 151
decreased circulating HDL chol... 6 | 68
decreased circulating alanine ... 6 | 47
decreased circulating serum al... 6 | 82
decreased circulating triglyce... 6 | 79
decreased lean body mass 6 | 135
embryonic lethality prior to t... 6 | 278
short tibia 6 | 97
abnormal cornea morphology 5 | 31
decreased caudal vertebrae num... 5 | 53
decreased circulating choleste... 5 | 93
decreased circulating fructosa... 5 | 30
decreased vertical activity 5 | 208
increased bone mineral content 5 | 108
increased circulating HDL chol... 5 | 80
increased neutrophil cell numb... 5 | 46
increased or absent threshold ... 5 | 101
abnormal embryo size 4 | 220
decreased circulating creatini... 4 | 39
decreased leukocyte cell numbe... 4 | 73
enlarged heart 4 | 210
impaired glucose tolerance 4 | 75
improved glucose tolerance 4 | 79
increased bone mineral density 4 | 72
increased circulating choleste... 4 | 66
increased heart weight 4 | 62
increased hemoglobin content 4 | 45
increased leukocyte cell numbe... 4 | 47
abnormal eye morphology 3 | 68
abnormal gait 3 | 69
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
abnormal tooth morphology 3 | 24
cataract 3 | 92
decreased circulating LDL chol... 3 | 38
decreased circulating alkaline... 3 | 46
decreased circulating glucose ... 3 | 126
decreased circulating sodium l... 3 | 22
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased hemoglobin content 3 | 68
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
edema 3 | 59
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
enlarged spleen 3 | 41
hyperactivity 3 | 148
increased blood urea nitrogen ... 3 | 48
increased circulating free fat... 3 | 20
increased erythrocyte cell num... 3 | 39
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
abnormal epididymis morphology 2 | 42
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
abnormal vibrissa morphology 2 | 25
corneal opacity 2 | 32
decreased T cell number 2 | 15
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating chloride... 2 | 30
decreased circulating free fat... 2 | 31
decreased circulating insulin ... 2 | 76
decreased hematocrit 2 | 46
decreased mean corpuscular hem... 2 | 31
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
enlarged kidney 2 | 14
enlarged lymph nodes 2 | 37
impaired righting response 2 | 26
increased circulating calcium ... 2 | 34
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased circulating total pr... 2 | 28
increased eosinophil cell numb... 2 | 11
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
tremors 2 | 39

Disease

Carcinoma 370 | 11,493
ovarian cancer 331 | 8,520
osteosarcoma 258 | 7,950
Cancer 230 | 2,499
glioblastoma 230 | 5,792
psoriasis 225 | 6,694
medulloblastoma, large-cell 222 | 6,241
lung cancer 198 | 4,740
atypical teratoid / rhabdoid tumor 188 | 5,112
ependymoma 180 | 4,679
Breast cancer 171 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 138 | 3,291
pancreatic cancer 136 | 2,398
non-small cell lung cancer 134 | 2,890
group 3 medulloblastoma 126 | 4,104
Kidney cancer 124 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 123 | 2,989
malignant mesothelioma 123 | 3,232
Astrocytoma, Pilocytic 122 | 3,081
oligodendroglioma 119 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 118 | 2,955
lung adenocarcinoma 118 | 2,716
adult high grade glioma 114 | 3,801
invasive ductal carcinoma 114 | 2,951
astrocytic glioma 107 | 2,597
primitive neuroectodermal tumor 107 | 3,035
subependymal giant cell astrocytoma 101 | 2,287
lung carcinoma 96 | 2,843
group 4 medulloblastoma 93 | 1,855
interstitial cystitis 85 | 2,312
breast carcinoma 83 | 1,638
tuberculosis 82 | 2,010
Pick disease 79 | 1,894
diabetes mellitus 79 | 1,728
ulcerative colitis 74 | 1,819
juvenile dermatomyositis 72 | 1,187
Multiple myeloma 71 | 1,332
astrocytoma 71 | 1,146
ductal carcinoma in situ 71 | 1,745
acute quadriplegic myopathy 70 | 1,158
pituitary cancer 70 | 1,972
primary pancreatic ductal adenocarcinoma 70 | 1,109
dermatomyositis 66 | 966
spina bifida 65 | 1,074
Schizophrenia 63 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 63 | 1,962
Waldenstrons macroglobulinemia 62 | 765
Rheumatoid arthritis 61 | 1,191
colon cancer 61 | 1,478
cystic fibrosis 60 | 1,696
pediatric high grade glioma 55 | 1,064
Autosomal recessive predisposition 53 | 1,442
Breast Neoplasms 49 | 445
Liver Cirrhosis, Experimental 49 | 769
adrenocortical carcinoma 48 | 1,428
Mammary Neoplasms 47 | 425
Alzheimer's disease 45 | 658
Prostatic Neoplasms 42 | 495
esophageal adenocarcinoma 41 | 737
Intellectual disability 40 | 1,016
autosomal dominant Emery-Dreifuss muscular dystrophy 40 | 510
gastric carcinoma 40 | 807
Down syndrome 38 | 499
Duchenne muscular dystrophy 37 | 601
Neoplasm Invasiveness 36 | 161
cutaneous lupus erythematosus 36 | 1,057
Stomach Neoplasms 35 | 300
Vascular disease 35 | 319
nasopharyngeal carcinoma 35 | 1,058
Amyotrophic lateral sclerosis 34 | 451
Lung Neoplasms 34 | 232
Melanoma 34 | 711
primary Sjogren syndrome 34 | 735
Depressive disorder 32 | 409
Liver cancer 32 | 604
non primary Sjogren syndrome sicca 32 | 891
Hypertensive disease 31 | 292
Neoplasm Metastasis 31 | 168
Obesity 31 | 678
Liver carcinoma 30 | 240
Renal Cell Carcinoma 30 | 214
Short stature 30 | 531
acute myeloid leukemia 30 | 783
Carcinoma, Hepatocellular 29 | 228
Epilepsy 29 | 792
Parkinson's disease 29 | 392
aldosterone-producing adenoma 29 | 665
Bipolar Disorder 28 | 666
Dull intelligence 28 | 645
Hypertension 28 | 396
Low intelligence 28 | 645
Mental Retardation 28 | 645
Mental deficiency 28 | 645
Poor school performance 28 | 645
fibroadenoma 28 | 559
Cognitive delay 27 | 608
Global developmental delay 27 | 608
Mental and motor retardation 27 | 608
Orbital separation excessive 27 | 244
progressive supranuclear palsy 27 | 676

Tissue

Blood and immune system 470 | 16,909
Digestive Tract 470 | 17,369
Endocrine System 470 | 18,159
Female tissues 470 | 17,400
Male tissues 470 | 17,142
Skin and soft tissues 470 | 17,230
Liver and Pancreas 469 | 16,750
Respiratory system 469 | 16,393
Urinary Tract 469 | 16,678
Nervous System 466 | 16,725
Cardiovascular System 462 | 15,192

Target Family

Non-IDG 253 | 12,091
Kinase 97 | 634
Enzyme 85 | 4,145
Transcription Factor 28 | 1,400
Transporter 5 | 473
Epigenetic 3 | 242
GPCR 1 | 408

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Caskin-2 CASKIN2 Tdark Non-IDG -0.21450 1.97 118
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Palmitoyltransferase ZDHHC5 ZDHHC5 Tbio Enzyme -0.94454 9.00 61
Epsin-1 EPN1 Tbio Non-IDG -1.52389 32.5 163