Development Level

Tbio 98 | 11,445
Tchem 51 | 1,598
Tclin 12 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 5 | 278
abnormal behavior 4 | 298
decreased total body fat amoun... 4 | 207
abnormal retina morphology 3 | 71
decreased vertical activity 3 | 208
increased bone mineral density 3 | 72
increased circulating choleste... 3 | 66
increased startle reflex 3 | 112
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal skin coloration 2 | 25
decreased circulating glucose ... 2 | 126
decreased lean body mass 2 | 135
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating glycerol... 2 | 9
increased heart rate 2 | 23
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
shortened RR interval 2 | 17
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal embryonic autopod pla... 1 | 2
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal liver size 1 | 5
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal social-conspecific in... 1 | 3
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart 1 | 210
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased caudal vertebrae num... 1 | 7
increased circulating calcium ... 1 | 34
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
male infertility 1 | 123
mammalian phenotype 1 | 17
pale liver 1 | 6
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19

Disease

Carcinoma 122 | 11,493
ovarian cancer 117 | 8,520
Cancer 101 | 2,499
osteosarcoma 97 | 7,950
psoriasis 73 | 6,694
glioblastoma 72 | 5,792
lung cancer 72 | 4,740
medulloblastoma, large-cell 70 | 6,241
Breast cancer 61 | 3,578
atypical teratoid / rhabdoid tumor 59 | 5,112
ependymoma 47 | 4,679
malignant mesothelioma 45 | 3,232
diabetes mellitus 40 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
group 3 medulloblastoma 39 | 4,104
lung adenocarcinoma 36 | 2,716
primitive neuroectodermal tumor 36 | 3,035
Kidney cancer 35 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,989
Multiple myeloma 34 | 1,332
adult high grade glioma 34 | 3,801
Breast Neoplasms 33 | 445
Mammary Neoplasms 33 | 425
non-small cell lung cancer 33 | 2,890
oligodendroglioma 33 | 2,850
invasive ductal carcinoma 32 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,962
Prostatic Neoplasms 31 | 495
Astrocytoma, Pilocytic 29 | 3,081
astrocytoma 29 | 1,146
breast carcinoma 28 | 1,638
subependymal giant cell astrocytoma 28 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
pancreatic cancer 27 | 2,398
Pick disease 26 | 1,894
Rheumatoid arthritis 26 | 1,191
Schizophrenia 26 | 1,160
colon cancer 26 | 1,478
Obesity 24 | 678
astrocytic glioma 24 | 2,597
ductal carcinoma in situ 24 | 1,745
Bipolar Disorder 23 | 666
Waldenstrons macroglobulinemia 23 | 765
acute quadriplegic myopathy 23 | 1,158
Intellectual disability 22 | 1,016
lung carcinoma 22 | 2,843
tuberculosis 22 | 2,010
Vascular disease 21 | 319
group 4 medulloblastoma 21 | 1,855
pediatric high grade glioma 21 | 1,064
ulcerative colitis 21 | 1,819
juvenile dermatomyositis 20 | 1,187
Carcinoma, Hepatocellular 18 | 228
pituitary cancer 18 | 1,972
Autosomal recessive predisposition 17 | 1,442
Endometriosis 17 | 540
Liver carcinoma 17 | 240
Parkinson's disease 17 | 392
Squamous cell carcinoma 17 | 129
dermatomyositis 17 | 966
interstitial cystitis 17 | 2,312
Liver Cirrhosis, Experimental 16 | 769
Melanoma 16 | 711
Stomach Neoplasms 16 | 300
Alzheimer's disease 15 | 658
Carcinoma, Squamous Cell 15 | 110
Colorectal Neoplasms 15 | 243
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
Short stature 15 | 531
adrenocortical carcinoma 15 | 1,428
Cognitive delay 14 | 608
Epilepsy 14 | 792
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Neoplasm Metastasis 14 | 168
cystic fibrosis 14 | 1,696
spina bifida 14 | 1,074
Asthma 13 | 385
Crohn's disease 13 | 321
Heart disease 13 | 306
Kidney disease 13 | 430
Mammary Neoplasms, Experimental 13 | 154
Muscle hypotonia 13 | 571
Strabismus 13 | 270
Toxic encephalopathy 13 | 141
aldosterone-producing adenoma 13 | 665
medulloblastoma 13 | 720
Acquired scoliosis 12 | 281
Cryptorchidism 12 | 296
Curvature of spine 12 | 282
Lung Neoplasms 12 | 232
Mood Disorders 12 | 184
Neurodegenerative disease 12 | 414
Seizures 12 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 510
Hypoplastic mandible condyle 11 | 275

Tissue

Endocrine System 162 | 18,159
Digestive Tract 161 | 17,369
Female tissues 161 | 17,400
Male tissues 161 | 17,142
Respiratory system 161 | 16,393
Skin and soft tissues 161 | 17,230
Blood and immune system 160 | 16,909
Liver and Pancreas 160 | 16,750
Nervous System 160 | 16,725
Urinary Tract 160 | 16,678
Cardiovascular System 158 | 15,192

Target Family

Non-IDG 60 | 12,091
Enzyme 34 | 4,145
Transcription Factor 31 | 1,400
Epigenetic 15 | 242
Kinase 14 | 634
Nuclear Receptor 6 | 48
TF/Epigenetic 3 | 38
Transporter 1 | 473

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
SNRPN upstream reading frame protein SNURF Tbio Non-IDG -1.05125 8.44 12
BAG family molecular chaperone regulator 1 BAG1 Tbio Non-IDG -2.50252 335.1 394
Lysine-specific demethylase 3A KDM3A Tchem Epigenetic -1.83544 74.7 253
POZ-, AT hook-, and zinc finger-containing protein 1 PATZ1 Tbio Transcription Factor -1.98463 95.1 106
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.07841 114.8 103
EF-hand calcium-binding domain-containing protein 6 EFCAB6 Tdark Non-IDG -0.67693 4.17 19
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Nuclear receptor subfamily 2 group C member 1 NR2C1 Tbio Nuclear Receptor -1.39182 24.4 294
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148