Development Level

Tchem 18 | 1,598
Tbio 16 | 11,445
Tclin 10 | 613

IMPC Phenotype

decreased total body fat amoun... 4 | 207
preweaning lethality, complete... 4 | 979
increased mean corpuscular hem... 3 | 96
thrombocytopenia 3 | 56
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased prepulse inhibition 2 | 82
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased heart rate 2 | 23
preweaning lethality, incomple... 2 | 499
shortened RR interval 2 | 17
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased leukocyte cell numbe... 1 | 73
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
enlarged spleen 1 | 41
hypoactivity 1 | 132
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating phosphat... 1 | 26
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
thrombocytosis 1 | 27

Disease

Carcinoma 32 | 11,493
Cancer 29 | 2,499
ovarian cancer 29 | 8,520
osteosarcoma 24 | 7,950
psoriasis 20 | 6,694
glioblastoma 18 | 5,792
lung cancer 18 | 4,740
diabetes mellitus 16 | 1,728
group 3 medulloblastoma 15 | 4,104
medulloblastoma, large-cell 15 | 6,241
Kidney cancer 14 | 2,613
ependymoma 14 | 4,679
Breast cancer 13 | 3,578
Schizophrenia 13 | 1,160
atypical teratoid / rhabdoid tumor 13 | 5,112
malignant mesothelioma 13 | 3,232
Breast Neoplasms 11 | 445
Intellectual disability 11 | 1,016
Mammary Neoplasms 11 | 425
Vascular disease 11 | 319
subependymal giant cell astrocytoma 10 | 2,287
Bipolar Disorder 9 | 666
Epilepsy 9 | 792
Obesity 9 | 678
Renal Cell Carcinoma 9 | 214
pancreatic cancer 9 | 2,398
primitive neuroectodermal tumor 9 | 3,035
Autosomal recessive predisposition 8 | 1,442
Cognitive delay 8 | 608
Dull intelligence 8 | 645
Global developmental delay 8 | 608
Hypertensive disease 8 | 292
Low intelligence 8 | 645
Major Depressive Disorder 8 | 301
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Poor school performance 8 | 645
Short stature 8 | 531
Stomach Neoplasms 8 | 300
Unipolar Depression 8 | 250
acute quadriplegic myopathy 8 | 1,158
group 4 medulloblastoma 8 | 1,855
juvenile dermatomyositis 8 | 1,187
pituitary cancer 8 | 1,972
Alzheimer's disease 7 | 658
Astrocytoma, Pilocytic 7 | 3,081
Concave bridge of nose 7 | 195
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Depressive disorder 7 | 409
Hypertension 7 | 396
Lung Neoplasms 7 | 232
Orbital separation excessive 7 | 244
Pick disease 7 | 1,894
adult high grade glioma 7 | 3,801
interstitial cystitis 7 | 2,312
lung adenocarcinoma 7 | 2,716
lung carcinoma 7 | 2,843
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
ulcerative colitis 7 | 1,819
Acquired scoliosis 6 | 281
Carcinoma, Hepatocellular 6 | 228
Carcinoma, Squamous Cell 6 | 110
Cardiomyopathies 6 | 110
Congenital Epicanthus 6 | 177
Curvature of spine 6 | 282
Downward slant of palpebral fissure 6 | 158
Liver carcinoma 6 | 240
Multiple myeloma 6 | 1,332
Neoplasm Invasiveness 6 | 161
Seizures 6 | 596
Squamous cell carcinoma 6 | 129
astrocytic glioma 6 | 2,597
breast carcinoma 6 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
tuberculosis 6 | 2,010
Arthritis 5 | 290
Byzanthine arch palate 5 | 194
Colonic Neoplasms 5 | 142
Delayed bone age 5 | 136
Heart disease 5 | 306
Kidney disease 5 | 430
Male infertility 5 | 206
Mental Depression 5 | 333
Parkinson's disease 5 | 392
Pectus excavatum 5 | 100
Prostatic Neoplasms 5 | 495
Rheumatoid arthritis 5 | 1,191
Waldenstrons macroglobulinemia 5 | 765
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
colon cancer 5 | 1,478
dermatomyositis 5 | 966
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Endocrine System 43 | 18,159
Female tissues 43 | 17,400
Liver and Pancreas 43 | 16,750
Nervous System 43 | 16,725
Blood and immune system 42 | 16,909
Cardiovascular System 42 | 15,192
Digestive Tract 42 | 17,369
Male tissues 42 | 17,142
Respiratory system 42 | 16,393
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678

Target Family

Kinase 20 | 634
Non-IDG 13 | 12,091
Enzyme 5 | 4,145
Transcription Factor 4 | 1,400
GPCR 1 | 408
Nuclear Receptor 1 | 48

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478