Development Level

Tbio 162 | 11,445
Tchem 91 | 1,598
Tclin 14 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 29 | 979
preweaning lethality, incomple... 11 | 499
increased total body fat amoun... 7 | 134
abnormal bone structure 6 | 187
abnormal behavior 5 | 298
decreased bone mineral content 5 | 151
decreased mean corpuscular vol... 5 | 79
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
abnormal lens morphology 4 | 81
increased circulating choleste... 4 | 66
increased lean body mass 4 | 172
increased lymphocyte cell numb... 4 | 32
prenatal lethality prior to he... 4 | 87
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
cataract 3 | 92
decreased blood urea nitrogen ... 3 | 51
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
decreased circulating creatini... 3 | 39
decreased circulating sodium l... 3 | 22
decreased circulating triglyce... 3 | 79
decreased lean body mass 3 | 135
decreased neutrophil cell numb... 3 | 42
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
hypoactivity 3 | 132
impaired righting response 3 | 26
increased circulating HDL chol... 3 | 80
increased circulating LDL chol... 3 | 13
increased circulating alkaline... 3 | 122
increased circulating free fat... 3 | 20
increased large unstained cell... 3 | 5
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular hem... 3 | 96
increased neutrophil cell numb... 3 | 46
small testis 3 | 58
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
abnormal testis morphology 2 | 43
absent vibrissae 2 | 12
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating fructosa... 2 | 30
decreased circulating insulin ... 2 | 76
decreased eosinophil cell numb... 2 | 24
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased threshold for audito... 2 | 26
edema 2 | 59
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
increased bone mineral content 2 | 108
increased circulating calcium ... 2 | 34
increased circulating iron lev... 2 | 30
increased circulating total pr... 2 | 28
increased eosinophil cell numb... 2 | 11
increased heart rate 2 | 23
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
male infertility 2 | 123
short tibia 2 | 97
shortened RR interval 2 | 17
thrombocytopenia 2 | 56
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retinal vasculature m... 1 | 27
abnormal tooth morphology 1 | 24
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased mean corpuscular hem... 1 | 31
enlarged spleen 1 | 41
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating aspartat... 1 | 15
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74
stereotypic behavior 1 | 3
thrombocytosis 1 | 27

Disease

Carcinoma 196 | 11,493
ovarian cancer 186 | 8,520
osteosarcoma 149 | 7,950
Cancer 132 | 2,499
psoriasis 121 | 6,694
glioblastoma 118 | 5,792
medulloblastoma, large-cell 112 | 6,241
lung cancer 111 | 4,740
atypical teratoid / rhabdoid tumor 99 | 5,112
ependymoma 77 | 4,679
Breast cancer 72 | 3,578
group 3 medulloblastoma 70 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 67 | 3,291
Kidney cancer 64 | 2,613
Multiple myeloma 62 | 1,332
adult high grade glioma 62 | 3,801
oligodendroglioma 57 | 2,850
malignant mesothelioma 53 | 3,232
diabetes mellitus 52 | 1,728
lung adenocarcinoma 52 | 2,716
primitive neuroectodermal tumor 52 | 3,035
subependymal giant cell astrocytoma 52 | 2,287
non-small cell lung cancer 49 | 2,890
Astrocytoma, Pilocytic 47 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,989
lung carcinoma 47 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,955
pancreatic cancer 46 | 2,398
Rheumatoid arthritis 45 | 1,191
invasive ductal carcinoma 44 | 2,951
tuberculosis 44 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 43 | 1,962
astrocytic glioma 42 | 2,597
group 4 medulloblastoma 40 | 1,855
Pick disease 37 | 1,894
acute quadriplegic myopathy 37 | 1,158
dermatomyositis 37 | 966
astrocytoma 35 | 1,146
Schizophrenia 34 | 1,160
interstitial cystitis 34 | 2,312
juvenile dermatomyositis 34 | 1,187
Autosomal recessive predisposition 31 | 1,442
spina bifida 31 | 1,074
Breast Neoplasms 30 | 445
adrenocortical carcinoma 30 | 1,428
colon cancer 30 | 1,478
Intellectual disability 29 | 1,016
Mammary Neoplasms 29 | 425
Vascular disease 29 | 319
breast carcinoma 29 | 1,638
pituitary cancer 29 | 1,972
primary pancreatic ductal adenocarcinoma 29 | 1,109
ulcerative colitis 29 | 1,819
cystic fibrosis 28 | 1,696
Short stature 25 | 531
Waldenstrons macroglobulinemia 24 | 765
ductal carcinoma in situ 24 | 1,745
Liver Cirrhosis, Experimental 23 | 769
Prostatic Neoplasms 22 | 495
acute myeloid leukemia 22 | 783
Carcinoma, Hepatocellular 21 | 228
Liver carcinoma 21 | 240
Stomach Neoplasms 21 | 300
esophageal adenocarcinoma 21 | 737
Alzheimer's disease 20 | 658
Bipolar Disorder 20 | 666
Dull intelligence 20 | 645
Low intelligence 20 | 645
Lung Neoplasms 20 | 232
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Obesity 20 | 678
Parkinson's disease 20 | 392
Poor school performance 20 | 645
cutaneous lupus erythematosus 20 | 1,057
Arthritis 19 | 290
Epilepsy 19 | 792
pancreatic carcinoma 19 | 562
pediatric high grade glioma 19 | 1,064
Acquired scoliosis 18 | 281
Asthma 18 | 385
Curvature of spine 18 | 282
Hypoplastic mandible condyle 18 | 275
Mandibular hypoplasia 18 | 275
Micrognathism 18 | 275
Muscle hypotonia 18 | 571
medulloblastoma 18 | 720
Brain Ischemia 17 | 110
Diabetes Mellitus, Experimental 17 | 108
Melanoma 17 | 711
Multiple Sclerosis 17 | 540
Neoplasm Metastasis 17 | 168
Renal Cell Carcinoma 17 | 214
Seizures 17 | 596
Atopic dermatitis 16 | 952
Endometriosis 16 | 540
Hypertension 16 | 396
Kidney disease 16 | 430
Toxic encephalopathy 16 | 141
hepatocellular carcinoma 16 | 547

Tissue

Blood and immune system 270 | 16,909
Digestive Tract 270 | 17,369
Endocrine System 270 | 18,159
Male tissues 270 | 17,142
Skin and soft tissues 270 | 17,230
Female tissues 269 | 17,400
Liver and Pancreas 269 | 16,750
Nervous System 269 | 16,725
Urinary Tract 269 | 16,678
Cardiovascular System 268 | 15,192
Respiratory system 268 | 16,393

Target Family

Non-IDG 123 | 12,091
Enzyme 61 | 4,145
Kinase 54 | 634
Transcription Factor 20 | 1,400
Epigenetic 7 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38
Ion Channel 1 | 344

PathwayCommons: netpath Pathway

http://pathwaycommons.org/pc2/... 270 | 270
http://pathwaycommons.org/pc2/... 472 | 472
http://pathwaycommons.org/pc2/... 258 | 258
http://pathwaycommons.org/pc2/... 220 | 220
http://pathwaycommons.org/pc2/... 164 | 164
http://pathwaycommons.org/pc2/... 161 | 161
http://pathwaycommons.org/pc2/... 118 | 118
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 104 | 104
http://pathwaycommons.org/pc2/... 98 | 98
http://pathwaycommons.org/pc2/... 85 | 85
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 84 | 84
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 81 | 81
http://pathwaycommons.org/pc2/... 76 | 76
http://pathwaycommons.org/pc2/... 74 | 74
http://pathwaycommons.org/pc2/... 73 | 73
http://pathwaycommons.org/pc2/... 69 | 69
http://pathwaycommons.org/pc2/... 59 | 59
http://pathwaycommons.org/pc2/... 44 | 44
http://pathwaycommons.org/pc2/... 39 | 39
http://pathwaycommons.org/pc2/... 38 | 38
http://pathwaycommons.org/pc2/... 35 | 35
http://pathwaycommons.org/pc2/... 28 | 28
http://pathwaycommons.org/pc2/... 24 | 24
http://pathwaycommons.org/pc2/... 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase TRAF7 TRAF7 Tbio Enzyme -1.09531 13.0 112
Tumor necrosis factor receptor superfamily member 11A TNFRSF11A Tbio Non-IDG -3.26478 1689.0 464
MAP kinase-activating death domain protein MADD Tbio Enzyme -1.86555 79.6 121
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
Serine/threonine-protein kinase MARK2 MARK2 Tchem Kinase -2.49873 272.3 322
Tax1-binding protein 1 TAX1BP1 Tbio Non-IDG -1.44609 30.4 133
Leucine-rich PPR motif-containing protein, mitochondrial LRPPRC Tbio Non-IDG -1.67434 54.1 80
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448