Development Level

Tchem 38 | 1,890
Tbio 37 | 10,625
Tclin 9 | 602

IMPC Phenotype

preweaning lethality, complete... 8 | 633
decreased lean body mass 4 | 195
decreased body weight 3 | 174
abnormal behavior 2 | 226
abnormal bone mineralization 2 | 55
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating triglyce... 2 | 83
decreased mean corpuscular hem... 2 | 34
embryonic lethality prior to t... 2 | 187
increased circulating LDL chol... 2 | 15
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
increased lean body mass 2 | 107
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 5
abnormal lens morphology 1 | 73
abnormal respiratory quotient 1 | 9
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 18
absent vibrissae 1 | 14
decreased B cell number 1 | 30
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased thermal nociceptive ... 1 | 4
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating free fat... 1 | 17
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 57
male infertility 1 | 62
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260
small superior vagus ganglion 1 | 20
thrombocytosis 1 | 23
tremors 1 | 34

Disease

Cancer 63 | 2,346
ovarian cancer 53 | 8,491
osteosarcoma 51 | 7,933
lung cancer 41 | 4,473
psoriasis 38 | 6,685
glioblastoma 36 | 5,572
medulloblastoma, large-cell 33 | 6,234
atypical teratoid / rhabdoid tumor 26 | 4,369
pancreatic cancer 23 | 2,300
tuberculosis 22 | 1,563
lung carcinoma 21 | 2,844
non-small cell lung cancer 21 | 2,798
Rheumatoid Arthritis 20 | 1,170
diabetes mellitus 20 | 1,663
subependymal giant cell astrocytoma 19 | 2,287
Breast cancer 18 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
malignant mesothelioma 18 | 3,163
oligodendroglioma 18 | 2,849
ulcerative colitis 18 | 2,087
Carcinoma 17 | 2,147
ependymoma 17 | 2,514
lung adenocarcinoma 17 | 2,714
Arthritis 16 | 248
Pick disease 16 | 1,893
Vascular disease 16 | 281
interstitial cystitis 16 | 2,299
juvenile dermatomyositis 16 | 1,189
pilocytic astrocytoma 16 | 3,086
astrocytoma 15 | 1,493
group 4 medulloblastoma 15 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
primitive neuroectodermal tumor 15 | 3,031
Alzheimer's disease 14 | 644
Multiple myeloma 14 | 1,327
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
invasive ductal carcinoma 14 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
dermatomyositis 13 | 966
pediatric high grade glioma 13 | 2,712
pituitary cancer 13 | 1,972
Mammary Neoplasms 12 | 410
Obesity 12 | 616
medulloblastoma 12 | 1,524
adult high grade glioma 11 | 2,148
colon cancer 11 | 1,475
Asthma 10 | 349
Kidney disease 10 | 397
Waldenstrons macroglobulinemia 10 | 764
astrocytic glioma 10 | 2,241
cystic fibrosis 10 | 1,670
primary Sjogren syndrome 10 | 788
primary pancreatic ductal adenocarcinoma 10 | 1,271
Liver carcinoma 9 | 217
Lung Neoplasms 9 | 171
Lung disease 9 | 136
Multiple Sclerosis 9 | 498
Osteopetrosis 9 | 40
Osteoporosis 9 | 259
Parkinson's disease 9 | 364
acute quadriplegic myopathy 9 | 1,157
ductal carcinoma in situ 9 | 1,745
spina bifida 9 | 1,064
Brain Ischemia 8 | 87
Prostatic Neoplasms 8 | 471
Stomach Neoplasms 8 | 282
active Crohn's disease 8 | 918
acute myeloid leukemia 8 | 785
cutaneous lupus erythematosus 8 | 1,056
sonic hedgehog group medulloblastoma 8 | 1,482
Amyotrophic Lateral Sclerosis 7 | 432
Neoplasm Invasiveness 7 | 127
Toxic encephalopathy 7 | 131
gastric carcinoma 7 | 832
mucosa-associated lymphoid tissue lymphoma 7 | 480
nasopharyngeal carcinoma 7 | 1,056
Colonic Neoplasms 6 | 126
Heat Stroke 6 | 12
IGA Glomerulonephritis 6 | 454
Neoplasm Metastasis 6 | 138
Squamous cell carcinoma 6 | 96
adrenocortical carcinoma 6 | 1,427
breast carcinoma 6 | 1,614
chronic lymphocytic leukemia 6 | 244
esophageal adenocarcinoma 6 | 737
group 3 medulloblastoma 6 | 2,254
ovarian neoplasm 6 | 97
pancreatic carcinoma 6 | 567
periodontitis 6 | 269
posterior fossa group A ependymoma 6 | 1,511
Adenocarcinoma 5 | 115
Anemia 5 | 252
Cardiomyopathies 5 | 90
Inflammatory bowel disease 5 | 142
Melanoma 5 | 261
Renal Cell Carcinoma 5 | 199
Reperfusion Injury 5 | 84
Thrombocytopenia 5 | 105
fibroadenoma 5 | 557
inflammatory breast cancer 5 | 404

Tissue

Blood and immune system 84 | 17,994
Cardiovascular System 84 | 17,957
Digestive Tract 84 | 18,472
Endocrine System 84 | 18,511
Female tissues 84 | 18,646
Liver and Pancreas 84 | 18,135
Male tissues 84 | 17,968
Nervous System 84 | 18,560
Respiratory system 84 | 17,483
Urinary Tract 84 | 18,443
Skin and soft tissues 83 | 18,114

Target Family

Kinase 30 | 634
Non-IDG 26 | 11,969
Transcription Factor 16 | 1,400
Enzyme 11 | 4,146
Epigenetic 1 | 242

PathwayCommons: netpath Pathway

RANKL 84 | 84
EGFR1 473 | 473
TNFalpha 271 | 271
TCR 259 | 259
TGF_beta_Receptor 220 | 220
AndrogenReceptor 164 | 164
BCR 161 | 161
Wnt 118 | 118
Prolactin 105 | 105
KitReceptor 104 | 104
Leptin 98 | 98
IL6 85 | 85
IL3 84 | 84
TSH 82 | 82
IL2 81 | 81
Notch 76 | 76
Alpha6Beta4Integrin 74 | 74
IL4 73 | 73
IL1 69 | 69
IL5 59 | 59
FSH 44 | 44
Hedgehog 39 | 39
ID 38 | 38
TWEAK 35 | 35
IL-7 28 | 28
IL9 24 | 24
TSLP 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.03044 1092.0 356
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.39396 233.2 634
Triggering receptor expressed on myeloid cells 2 TREM2 Tbio Non-IDG -2.32637 219.6 297
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.87718 69.0 145
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -1.97989 67.5 582
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.41371 28.0 678
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.25781 180.0 594
Heat shock protein HSP 90-alpha HSP90AA1 Tchem Non-IDG -3.28941 4395.5 921
5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 Tchem Kinase -1.87050 66.3 830
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.11789 1349.3 1026