Development Level

Tbio 302 | 10,625
Tchem 130 | 1,890
Tclin 30 | 602
Tdark 11 | 7,003

Collection

Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 19 | 633
decreased total body fat amoun... 14 | 186
preweaning lethality, incomple... 14 | 260
decreased lean body mass 13 | 195
abnormal bone structure 9 | 131
decreased body weight 9 | 174
decreased bone mineral content 9 | 157
abnormal retina morphology 7 | 100
decreased circulating HDL chol... 7 | 77
abnormal behavior 6 | 226
decreased bone mineral density 6 | 126
decreased circulating choleste... 6 | 85
decreased circulating fructosa... 6 | 31
decreased grip strength 6 | 123
increased circulating alkaline... 6 | 119
increased lean body mass 6 | 107
decreased circulating alanine ... 5 | 53
decreased circulating triglyce... 5 | 83
increased bone mineral content 5 | 92
abnormal cornea morphology 4 | 24
abnormal embryo size 4 | 112
abnormal retinal pigmentation 4 | 61
abnormal tooth morphology 4 | 24
decreased circulating alkaline... 4 | 41
decreased circulating serum al... 4 | 79
decreased fasted circulating g... 4 | 49
embryonic lethality prior to t... 4 | 187
impaired glucose tolerance 4 | 52
improved glucose tolerance 4 | 56
increased leukocyte cell numbe... 4 | 37
increased or absent threshold ... 4 | 128
abnormal coping response 3 | 12
abnormal hindbrain development 3 | 24
abnormal lens morphology 3 | 73
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
abnormal sleep behavior 3 | 63
decreased body length 3 | 108
decreased circulating LDL chol... 3 | 37
decreased circulating creatini... 3 | 31
decreased circulating glucose ... 3 | 121
decreased circulating insulin ... 3 | 75
decreased circulating sodium l... 3 | 18
decreased heart weight 3 | 44
decreased leukocyte cell numbe... 3 | 54
decreased lumbar vertebrae num... 3 | 62
decreased mature B cell number 3 | 25
decreased mean corpuscular hem... 3 | 34
increased blood urea nitrogen ... 3 | 44
increased erythrocyte cell num... 3 | 26
increased heart weight 3 | 37
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
abnormal QRS complex 2 | 25
abnormal bone mineralization 2 | 55
abnormal coat/ hair morphology 2 | 18
abnormal femur morphology 2 | 14
abnormal maxilla morphology 2 | 16
abnormal pericardium morpholog... 2 | 11
abnormal posture 2 | 5
abnormal vibrissa morphology 2 | 17
decreased T cell number 2 | 31
decreased blood urea nitrogen ... 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating free fat... 2 | 39
decreased circulating glycerol... 2 | 19
decreased mean corpuscular vol... 2 | 50
decreased spleen weight 2 | 13
decreased threshold for audito... 2 | 32
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
enlarged spleen 2 | 26
hypoactivity 2 | 89
increased T cell number 2 | 15
increased body weight 2 | 42
increased bone mineral density 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating calcium ... 2 | 32
increased circulating choleste... 2 | 53
increased circulating free fat... 2 | 17
increased circulating total pr... 2 | 20
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased prepulse inhibition 2 | 21
increased sacral vertebrae num... 2 | 62
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased IgG1 level 1 | 4
decreased circulating chloride... 1 | 32
decreased eosinophil cell numb... 1 | 41
decreased total retina thickne... 1 | 20
impaired righting response 1 | 19
increased body length 1 | 20
increased eosinophil cell numb... 1 | 9
increased mean platelet volume 1 | 19
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
trunk curl 1 | 15

Disease

ovarian cancer 330 | 8,484
osteosarcoma 259 | 7,933
psoriasis 227 | 6,685
glioblastoma 223 | 5,572
medulloblastoma, large-cell 223 | 6,234
Cancer 220 | 2,346
lung cancer 189 | 4,466
atypical teratoid / rhabdoid tumor 167 | 4,369
Breast cancer 152 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 138 | 3,289
pancreatic cancer 136 | 2,300
non-small cell lung cancer 131 | 2,798
pilocytic astrocytoma 127 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 123 | 2,988
oligodendroglioma 120 | 2,849
lung adenocarcinoma 119 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 118 | 2,956
pediatric high grade glioma 117 | 2,712
malignant mesothelioma 115 | 3,162
invasive ductal carcinoma 114 | 2,950
ependymoma 109 | 2,514
Carcinoma 108 | 2,147
primitive neuroectodermal tumor 108 | 3,031
subependymal giant cell astrocytoma 102 | 2,287
group 4 medulloblastoma 98 | 1,875
lung carcinoma 96 | 2,844
astrocytoma 94 | 1,493
ulcerative colitis 88 | 2,087
astrocytic glioma 85 | 2,241
interstitial cystitis 85 | 2,299
Pick disease 80 | 1,893
primary pancreatic ductal adenocarcinoma 79 | 1,271
breast carcinoma 76 | 1,614
diabetes mellitus 75 | 1,663
juvenile dermatomyositis 72 | 1,189
Multiple myeloma 71 | 1,327
acute quadriplegic myopathy 71 | 1,157
ductal carcinoma in situ 71 | 1,745
pituitary cancer 71 | 1,972
dermatomyositis 66 | 933
tuberculosis 66 | 1,557
medulloblastoma 65 | 1,524
spina bifida 65 | 1,064
Waldenstrons macroglobulinemia 63 | 765
posterior fossa group A ependymoma 63 | 1,511
colon cancer 62 | 1,475
Rheumatoid Arthritis 60 | 1,160
cystic fibrosis 57 | 1,665
adult high grade glioma 54 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,795
group 3 medulloblastoma 52 | 2,254
adrenocortical carcinoma 48 | 1,427
Alzheimer's disease 46 | 644
sonic hedgehog group medulloblastoma 46 | 1,482
Mammary Neoplasms 44 | 410
atypical teratoid/rhabdoid tumor 44 | 1,095
esophageal adenocarcinoma 41 | 737
Prostatic Neoplasms 40 | 471
gastric carcinoma 40 | 832
Down syndrome 39 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 39 | 499
Duchenne muscular dystrophy 37 | 602
cutaneous lupus erythematosus 36 | 1,056
nasopharyngeal carcinoma 36 | 1,056
primary Sjogren syndrome 36 | 789
posterior fossa group B ependymoma 34 | 1,530
Obesity 33 | 616
Vascular disease 33 | 281
Amyotrophic Lateral Sclerosis 32 | 431
Stomach Neoplasms 32 | 282
Neoplasm Invasiveness 30 | 127
non primary Sjogren syndrome sicca 30 | 840
Lung Neoplasms 29 | 171
acute myeloid leukemia 29 | 780
aldosterone-producing adenoma 29 | 664
pancreatic carcinoma 29 | 567
Liver carcinoma 28 | 217
Parkinson's disease 28 | 364
Renal Cell Carcinoma 28 | 199
fibroadenoma 28 | 557
Atopic dermatitis 27 | 944
Neoplasm Metastasis 27 | 138
progressive supranuclear palsy 27 | 674
tuberculosis and treatment for 6 months 27 | 686
Blastic phase chronic myeloid leukemia 26 | 58
Chronic Myelocytic Leukemia Accelerated Phase 26 | 59
non-small cell lung carcinoma 26 | 413
Animal Mammary Neoplasms 25 | 136
Kidney disease 25 | 396
Mammary Neoplasms, Experimental 25 | 150
Adenocarcinoma 24 | 115
Intellectual disability 24 | 573
Polycystic Ovary Syndrome 24 | 332
active Crohn's disease 24 | 918
Heart disease 23 | 279
IGA Glomerulonephritis 23 | 454
Hypertensive disease 22 | 193
Schizophrenia 22 | 501
Squamous cell carcinoma 22 | 94
interstitial lung disease 21 | 291

Tissue

Blood and immune system 473 | 17,995
Cardiovascular System 473 | 17,958
Digestive Tract 473 | 18,473
Endocrine System 473 | 18,512
Female tissues 473 | 18,647
Liver and Pancreas 473 | 18,136
Male tissues 473 | 17,969
Nervous System 473 | 18,561
Urinary Tract 473 | 18,444
Respiratory system 472 | 17,484
Skin and soft tissues 471 | 18,115

Target Family

Non-IDG 254 | 11,971
Kinase 97 | 634
Enzyme 85 | 4,146
Transcription Factor 28 | 1,400
Transporter 5 | 473
Epigenetic 3 | 242
GPCR 1 | 406

PathwayCommons: netpath Pathway

EGFR1 473 | 473
TNFalpha 271 | 271
TCR 259 | 259
TGF_beta_Receptor 220 | 220
AndrogenReceptor 164 | 164
BCR 161 | 161
Wnt 118 | 118
Prolactin 105 | 105
KitReceptor 104 | 104
Leptin 98 | 98
IL6 85 | 85
IL3 84 | 84
RANKL 84 | 84
TSH 82 | 82
IL2 81 | 81
Notch 76 | 76
Alpha6Beta4Integrin 74 | 74
IL4 73 | 73
IL1 69 | 69
IL5 59 | 59
FSH 44 | 44
Hedgehog 39 | 39
ID 38 | 38
TWEAK 35 | 35
IL-7 28 | 28
IL9 24 | 24
TSLP 24 | 24

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184