Development Level

Tbio 7,414 | 10,625
Tdark 2,761 | 7,003
Tchem 1,359 | 1,890
Tclin 366 | 602

Collection

Eligible Kinase Proteins 80 | 134
Eligible Ion Channel Proteins 48 | 117
Eligible non-olfactory GPCR Proteins 45 | 143

IMPC Term

preweaning lethality, complete... 531 | 633
preweaning lethality, incomple... 199 | 260
embryonic lethality prior to t... 166 | 187
abnormal behavior 163 | 226
decreased lean body mass 152 | 195
decreased total body fat amoun... 144 | 186
decreased body weight 137 | 174
embryonic lethality prior to o... 134 | 148
decreased bone mineral content 120 | 157
increased or absent threshold ... 100 | 128
abnormal embryo size 98 | 112
increased circulating alkaline... 97 | 119
abnormal bone structure 96 | 131
decreased bone mineral density 93 | 126
decreased body length 91 | 108
decreased circulating glucose ... 84 | 121
decreased grip strength 82 | 123
increased lean body mass 79 | 107
abnormal retina morphology 77 | 100
hyperactivity 76 | 108
enlarged heart 72 | 111
increased bone mineral content 70 | 92
increased mean corpuscular hem... 70 | 93
decreased circulating choleste... 68 | 85
increased mean corpuscular vol... 68 | 91
hypoactivity 63 | 89
decreased circulating serum al... 62 | 79
decreased circulating triglyce... 62 | 83
decreased circulating HDL chol... 61 | 77
increased grip strength 61 | 83
short tibia 58 | 82
abnormal lens morphology 54 | 73
prenatal lethality prior to he... 54 | 64
increased circulating sodium l... 50 | 71
decreased circulating insulin ... 49 | 75
increased fasted circulating g... 49 | 68
decreased lumbar vertebrae num... 47 | 62
increased circulating HDL chol... 45 | 63
abnormal bone mineralization 43 | 55
increased total body fat amoun... 43 | 57
increased sacral vertebrae num... 42 | 62
abnormal retinal pigmentation 41 | 61
decreased mean corpuscular vol... 41 | 50
decreased prepulse inhibition 41 | 52
decreased rib number 40 | 59
male infertility 40 | 62
decreased leukocyte cell numbe... 39 | 54
increased bone mineral density 39 | 52
abnormal sleep behavior 38 | 63
abnormal coat/hair pigmentatio... 37 | 54
decreased hemoglobin content 37 | 53
decreased startle reflex 37 | 48
impaired glucose tolerance 37 | 52
increased exploration in new e... 37 | 56
decreased circulating alanine ... 36 | 53
improved glucose tolerance 36 | 56
increased circulating choleste... 36 | 53
abnormal heart morphology 35 | 51
decreased caudal vertebrae num... 35 | 49
abnormal gait 34 | 51
abnormal neural tube closure 34 | 37
decreased fasted circulating g... 34 | 49
abnormal behavioral response t... 33 | 52
abnormal seminal vesicle morph... 33 | 47
decreased erythrocyte cell num... 33 | 43
thrombocytopenia 33 | 46
decreased heart weight 32 | 44
increased hemoglobin content 32 | 45
decreased circulating LDL chol... 31 | 37
decreased circulating alkaline... 31 | 41
decreased eosinophil cell numb... 31 | 41
increased circulating chloride... 31 | 43
abnormal eye morphology 30 | 38
decreased circulating calcium ... 30 | 33
decreased circulating total pr... 29 | 41
increased blood urea nitrogen ... 29 | 44
increased hematocrit 29 | 36
abnormal spleen morphology 28 | 36
decreased circulating free fat... 28 | 39
increased leukocyte cell numbe... 28 | 37
increased rib number 28 | 41
cardiovascular system phenotyp... 27 | 35
small testis 27 | 37
decreased mean corpuscular hem... 26 | 34
increased body weight 26 | 42
limb grasping 26 | 35
abnormal cranium morphology 25 | 32
decreased circulating fructosa... 25 | 31
decreased neutrophil cell numb... 25 | 37
increased circulating calcium ... 25 | 32
increased startle reflex 25 | 38
tremors 25 | 34
abnormal hindbrain development 24 | 24
abnormal testis morphology 23 | 30
decreased blood urea nitrogen ... 23 | 31
embryonic growth retardation 23 | 28
increased circulating creatini... 23 | 29
increased circulating potassiu... 23 | 31
increased erythrocyte cell num... 23 | 26
abnormal cornea morphology 22 | 24

Disease

ovarian cancer 6,493 | 8,484
osteosarcoma 5,688 | 7,933
medulloblastoma, large-cell 4,514 | 6,234
psoriasis 4,475 | 6,685
glioblastoma 4,160 | 5,572
lung cancer 3,475 | 4,466
atypical teratoid / rhabdoid tumor 3,220 | 4,369
malignant mesothelioma 2,478 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 2,473 | 3,289
Breast cancer 2,415 | 3,094
invasive ductal carcinoma 2,216 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,213 | 2,988
primitive neuroectodermal tumor 2,186 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 2,161 | 2,956
pilocytic astrocytoma 2,148 | 3,086
non-small cell lung cancer 2,086 | 2,798
oligodendroglioma 2,081 | 2,849
pediatric high grade glioma 2,040 | 2,712
lung adenocarcinoma 1,961 | 2,713
ependymoma 1,907 | 2,514
lung carcinoma 1,861 | 2,844
Cancer 1,763 | 2,346
pancreatic cancer 1,749 | 2,300
subependymal giant cell astrocytoma 1,661 | 2,287
group 3 medulloblastoma 1,618 | 2,254
astrocytic glioma 1,611 | 2,241
interstitial cystitis 1,521 | 2,299
ulcerative colitis 1,499 | 2,087
Carcinoma 1,477 | 2,147
Pick disease 1,468 | 1,893
adult high grade glioma 1,453 | 2,148
group 4 medulloblastoma 1,436 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,404 | 1,795
pituitary cancer 1,382 | 1,972
ductal carcinoma in situ 1,306 | 1,745
breast carcinoma 1,224 | 1,614
cystic fibrosis 1,214 | 1,665
astrocytoma 1,195 | 1,493
Multiple myeloma 1,168 | 1,327
tuberculosis 1,123 | 1,557
medulloblastoma 1,094 | 1,524
colon cancer 1,093 | 1,475
sonic hedgehog group medulloblastoma 1,076 | 1,482
diabetes mellitus 1,069 | 1,663
adrenocortical carcinoma 1,064 | 1,427
posterior fossa group A ependymoma 1,060 | 1,511
primary pancreatic ductal adenocarcinoma 1,014 | 1,271
acute quadriplegic myopathy 997 | 1,157
juvenile dermatomyositis 994 | 1,189
posterior fossa group B ependymoma 970 | 1,530
Rheumatoid Arthritis 890 | 1,160
spina bifida 809 | 1,064
atypical teratoid/rhabdoid tumor 808 | 1,095
dermatomyositis 790 | 933
nasopharyngeal carcinoma 718 | 1,056
cutaneous lupus erythematosus 702 | 1,056
Waldenstrons macroglobulinemia 673 | 765
Atopic dermatitis 668 | 944
active Crohn's disease 667 | 918
gastric carcinoma 636 | 832
acute myeloid leukemia 618 | 780
non primary Sjogren syndrome sicca 614 | 840
primary Sjogren syndrome 554 | 789
tuberculosis and treatment for 6 months 547 | 686
esophageal adenocarcinoma 539 | 737
progressive supranuclear palsy 536 | 674
aldosterone-producing adenoma 529 | 664
Duchenne muscular dystrophy 479 | 602
Alzheimer's disease 474 | 644
Down syndrome 439 | 548
Intellectual disability 436 | 573
pancreatic carcinoma 433 | 567
hepatocellular carcinoma 427 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 418 | 499
Obesity 409 | 616
Endometriosis 401 | 535
IGA Glomerulonephritis 386 | 454
Prostatic Neoplasms 380 | 471
fibroadenoma 368 | 557
Amyotrophic Lateral Sclerosis 365 | 431
Mammary Neoplasms 361 | 410
gastric cancer 345 | 430
active ulcerative colitis 338 | 477
Schizophrenia 329 | 501
chronic rhinosinusitis 329 | 512
mucosa-associated lymphoid tissue lymphoma 321 | 480
inflammatory breast cancer 300 | 404
Multiple Sclerosis 295 | 498
Neurodegenerative disease 294 | 383
non-small cell lung carcinoma 284 | 413
hereditary spastic paraplegia 277 | 313
Parkinson's disease 265 | 364
Polycystic Ovary Syndrome 261 | 332
sarcoidosis 261 | 358
tuberculosis and treatment for 3 months 251 | 327
glioblastoma multiforme 250 | 347
Kidney disease 239 | 396
Epilepsy 237 | 346
Stomach Neoplasms 232 | 282
interstitial lung disease 230 | 291

Tissue

Nervous System 11,761 | 18,561
Female tissues 11,760 | 18,647
Endocrine System 11,750 | 18,512
Digestive Tract 11,739 | 18,473
Urinary Tract 11,722 | 18,444
Liver and Pancreas 11,670 | 18,136
Male tissues 11,641 | 17,969
Skin and soft tissues 11,639 | 18,115
Blood and immune system 11,629 | 17,995
Cardiovascular System 11,614 | 17,958
Respiratory system 11,501 | 17,484

Target Family

Non-IDG 6,838 | 11,971
Enzyme 2,805 | 4,146
Transcription Factor 887 | 1,400
Kinase 472 | 634
Transporter 282 | 473
Epigenetic 197 | 242
Ion Channel 164 | 341
GPCR 163 | 406
Nuclear Receptor 39 | 48
oGPCR 28 | 421
TF/Epigenetic 25 | 38

PathwayCommons: mirtarbase Pathway

Homo sapiens 11,900 | 11,900
Kaposi sarcoma-associated herp... 13 | 13
Epstein Barr virus 4 | 4
Mus musculus 3 | 3
Rattus norvegicus 2 | 2

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158