Development Level

Tbio 32 | 11,651
Tchem 18 | 1,388
Tclin 8 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
decreased circulating LDL chol... 3 | 38
decreased mean platelet volume 3 | 25
short tibia 3 | 97
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased body weight 2 | 161
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
enlarged spleen 2 | 41
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal locomotor behavior 1 | 24
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged thymus 1 | 5
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased fasted circulating g... 1 | 76
increased glycosylated hemoglo... 1 | 1
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality 1 | 28
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 40 | 11,493
ovarian cancer 34 | 8,520
Cancer 31 | 2,499
osteosarcoma 31 | 7,950
glioblastoma 30 | 5,792
medulloblastoma, large-cell 30 | 6,241
atypical teratoid / rhabdoid tumor 29 | 5,112
psoriasis 26 | 6,694
Breast cancer 22 | 3,578
ependymoma 22 | 4,679
lung cancer 21 | 4,740
adult high grade glioma 19 | 3,801
Kidney cancer 18 | 2,613
astrocytic glioma 16 | 2,597
Epilepsy 15 | 792
Orbital separation excessive 15 | 244
oligodendroglioma 15 | 2,850
Seizures 14 | 596
group 3 medulloblastoma 14 | 4,104
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
group 4 medulloblastoma 13 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
subependymal giant cell astrocytoma 13 | 2,287
Downward slant of palpebral fissure 12 | 158
Schizophrenia 12 | 1,160
diabetes mellitus 12 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
primitive neuroectodermal tumor 12 | 3,035
Bipolar Disorder 11 | 666
Intellectual disability 11 | 1,016
pancreatic cancer 11 | 2,398
Astrocytoma, Pilocytic 10 | 3,081
Blepharoptosis 10 | 231
Byzanthine arch palate 10 | 194
Concave bridge of nose 10 | 195
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Dull intelligence 10 | 645
High forehead 10 | 102
Hypoplastic mandible condyle 10 | 275
Low intelligence 10 | 645
Mandibular hypoplasia 10 | 275
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Micrognathism 10 | 275
Muscle hypotonia 10 | 571
Pick disease 10 | 1,894
Poor school performance 10 | 645
Renal Cell Carcinoma 10 | 214
Rheumatoid arthritis 10 | 1,191
Stomach Neoplasms 10 | 300
Tall forehead 10 | 102
breast carcinoma 10 | 1,638
lung adenocarcinoma 10 | 2,716
malignant mesothelioma 10 | 3,232
Big calvaria 9 | 147
Delayed bone age 9 | 136
Increased head circumference 9 | 147
Increased size of cranium 9 | 147
Increased size of skull 9 | 147
Pectus excavatum 9 | 100
dermatomyositis 9 | 966
interstitial cystitis 9 | 2,312
invasive ductal carcinoma 9 | 2,951
juvenile dermatomyositis 9 | 1,187
Acquired scoliosis 8 | 281
Alzheimer's disease 8 | 658
Autosomal recessive predisposition 8 | 1,442
Carcinoma, Hepatocellular 8 | 228
Curvature of spine 8 | 282
Endometrial cancer 8 | 311
Excess nuchal skin 8 | 30
Frontal bossing 8 | 157
Full lower lip 8 | 64
Insulin Resistance 8 | 72
Joint hyperflexibility 8 | 78
Liver carcinoma 8 | 240
Multiple myeloma 8 | 1,332
Obesity 8 | 678
Prominent lower lip 8 | 64
Short stature 8 | 531
Strabismus 8 | 270
spina bifida 8 | 1,074
tuberculosis 8 | 2,010
Congenital Epicanthus 7 | 177
Dysarthria 7 | 192
Exophthalmos 7 | 112
Hepatomegaly 7 | 285
Lung Neoplasms 7 | 232
Parkinson's disease 7 | 392
Prominent eyes 7 | 96
Prostatic Neoplasms 7 | 495
Triangular face 7 | 58
Ventricular Septal Defects 7 | 119
ductal carcinoma in situ 7 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
primary pancreatic ductal adenocarcinoma 7 | 1,109

Tissue

Digestive Tract 58 | 17,369
Endocrine System 58 | 18,159
Female tissues 58 | 17,400
Skin and soft tissues 58 | 17,230
Cardiovascular System 57 | 15,192
Male tissues 57 | 17,142
Nervous System 57 | 16,725
Blood and immune system 56 | 16,909
Liver and Pancreas 56 | 16,750
Respiratory system 56 | 16,393
Urinary Tract 56 | 16,678

Target Family

Enzyme 21 | 4,145
Non-IDG 20 | 12,091
Kinase 17 | 634

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta PPP2R3B Tbio Enzyme -1.28190 19.5 142
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482
14-3-3 protein sigma SFN Tbio Non-IDG -2.56638 391.2 550
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 Tchem Kinase -1.42705 21.1 603
5'-AMP-activated protein kinase subunit gamma-1 PRKAG1 Tbio Kinase -1.00162 9.02 293
5'-AMP-activated protein kinase subunit beta-1 PRKAB1 Tbio Kinase -1.52519 32.5 532
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.59435 390.4 689
Target of rapamycin complex subunit LST8 MLST8 Tbio Non-IDG -2.64631 429.3 360