Development Level

Tbio 10 | 11,445
Tchem 3 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal allantois morphology 1 | 8
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retinal vasculature m... 1 | 27
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating chloride... 1 | 30
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
increased or absent threshold ... 1 | 101
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

ovarian cancer 10 | 8,520
Autosomal recessive predisposition 9 | 1,442
Carcinoma 8 | 11,493
Epilepsy 8 | 792
Seizures 8 | 596
glioblastoma 8 | 5,792
lung cancer 8 | 4,740
medulloblastoma, large-cell 8 | 6,241
osteosarcoma 8 | 7,950
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
atypical teratoid / rhabdoid tumor 7 | 5,112
non-small cell lung cancer 7 | 2,890
psoriasis 7 | 6,694
Cancer 6 | 2,499
Rheumatoid arthritis 6 | 1,191
primitive neuroectodermal tumor 6 | 3,035
Adverse reaction to drug 5 | 61
Arthritis, Rheumatoid 5 | 174
Bipolar Disorder 5 | 666
Cleft Lip 5 | 141
Cleft Palate 5 | 271
Drug-Related Side Effects and Adverse Reactions 5 | 62
Infantile onset 5 | 238
Muscle hypotonia 5 | 571
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
tuberculosis 5 | 2,010
Breast Neoplasms 4 | 445
Breast cancer 4 | 3,578
Choreoathetoid movements 4 | 32
Choreoathetosis 4 | 32
Colorectal Neoplasms 4 | 243
Down syndrome 4 | 499
Dull intelligence 4 | 645
Dystonia 4 | 164
Dystonic disease 4 | 106
Highly variable severity 4 | 157
Intellectual disability 4 | 1,016
Irritation - emotion 4 | 68
Kidney cancer 4 | 2,613
Low intelligence 4 | 645
Mammary Neoplasms 4 | 425
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Phenylketonuria 4 | 20
Poor school performance 4 | 645
Schizophrenia 4 | 1,160
Small head 4 | 374
Tremor 4 | 113
Variable expressivity 4 | 157
adrenocortical carcinoma 4 | 1,428
adult high grade glioma 4 | 3,801
ductal carcinoma in situ 4 | 1,745
malignant mesothelioma 4 | 3,232
nasopharyngeal carcinoma 4 | 1,058
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary Sjogren syndrome 4 | 735
Anemia 3 | 365
Cerebellar Ataxia 3 | 304
Deglutition Disorders 3 | 132
Drooling 3 | 27
Homocystinuria 3 | 21
Hyperactive behavior 3 | 91
Hyperhomocysteinemia 3 | 37
Hyperphenylalaninaemia 3 | 5
Hyperreflexia 3 | 209
Intermittent fever 3 | 15
Lymphoma, Follicular 3 | 18
Lymphoma, Non-Hodgkin 3 | 24
Malignant mesothelioma of pleura 3 | 7
Mood Disorders 3 | 184
Nervous System Diseases 3 | 53
Neural tube defect, folate-sensitive 3 | 4
Progressive neurologic deterioration 3 | 19
Sialorrhea 3 | 28
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
diabetes mellitus 3 | 1,728
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
nervous system disorder 3 | 53
neural tube defect 3 | 9
pancreatic cancer 3 | 2,398
spina bifida 3 | 1,074
Alzheimer's disease 2 | 658
Depressive disorder 2 | 409
Endometriosis 2 | 540
Male infertility 2 | 206
Mental Depression 2 | 333
Waldenstrons macroglobulinemia 2 | 765
acute quadriplegic myopathy 2 | 1,158
colon cancer 2 | 1,478
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Enzyme 14 | 4,145
Non-IDG 2 | 12,091

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 16 | 16
http://pathwaycommons.org/pc2/... 236 | 236
http://pathwaycommons.org/pc2/... 235 | 235
http://pathwaycommons.org/pc2/... 233 | 233
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http://pathwaycommons.org/pc2/... 85 | 85
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http://pathwaycommons.org/pc2/... 15 | 15

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bifunctional purine biosynthesis protein PURH ATIC Tchem Non-IDG -2.93014 835.0 246
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
GTP cyclohydrolase 1 GCH1 Tbio Enzyme -2.80099 639.3 247
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Sepiapterin reductase SPR Tbio Enzyme -1.58814 36.9 174
Dihydrofolate reductase DHFR Tclin Enzyme -2.99192 972.8 202
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Dihydropteridine reductase QDPR Tchem Enzyme -2.31177 200.8 146
Trifunctional purine biosynthetic protein adenosine-3 GART Tclin Non-IDG -2.26480 181.2 139