Development Level

Tbio 42 | 11,445
Tchem 7 | 1,598

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal heart morphology 4 | 162
enlarged heart 4 | 210
abnormal bone mineralization 2 | 38
cataract 2 | 92
decreased lymphocyte cell numb... 2 | 83
decreased vertical activity 2 | 208
increased startle reflex 2 | 112
mammalian phenotype 2 | 17
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal coat-hair pigmentatio... 1 | 64
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating serum al... 1 | 82
decreased exploration in new e... 1 | 11
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic lethality prior to t... 1 | 278
hydroencephaly 1 | 14
hyperactivity 1 | 148
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
kinked tail 1 | 2
mydriasis 1 | 6
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small heart 1 | 10
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 38 | 11,493
psoriasis 32 | 6,694
Cancer 26 | 2,499
ovarian cancer 24 | 8,520
glioblastoma 22 | 5,792
atypical teratoid / rhabdoid tumor 18 | 5,112
osteosarcoma 18 | 7,950
Breast cancer 17 | 3,578
medulloblastoma, large-cell 17 | 6,241
Astrocytoma, Pilocytic 16 | 3,081
ependymoma 16 | 4,679
invasive ductal carcinoma 15 | 2,951
interstitial cystitis 14 | 2,312
non-small cell lung cancer 14 | 2,890
lung cancer 13 | 4,740
pancreatic cancer 13 | 2,398
malignant mesothelioma 12 | 3,232
Osteoporosis 11 | 363
breast carcinoma 11 | 1,638
cutaneous lupus erythematosus 11 | 1,057
ductal carcinoma in situ 11 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
lung carcinoma 11 | 2,843
primitive neuroectodermal tumor 11 | 3,035
astrocytic glioma 10 | 2,597
group 3 medulloblastoma 10 | 4,104
lung adenocarcinoma 10 | 2,716
pituitary cancer 10 | 1,972
adrenocortical carcinoma 9 | 1,428
cystic fibrosis 9 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
oligodendroglioma 9 | 2,850
pediatric high grade glioma 9 | 1,064
primary pancreatic ductal adenocarcinoma 9 | 1,109
Autosomal recessive predisposition 8 | 1,442
Duchenne muscular dystrophy 8 | 601
adult high grade glioma 8 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Obesity 7 | 678
Schizophrenia 7 | 1,160
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
diabetes mellitus 7 | 1,728
group 4 medulloblastoma 7 | 1,855
juvenile dermatomyositis 7 | 1,187
Atopic dermatitis 6 | 952
Kidney cancer 6 | 2,613
Short stature 6 | 531
gastric carcinoma 6 | 807
non primary Sjogren syndrome sicca 6 | 891
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
tuberculosis 6 | 2,010
ulcerative colitis 6 | 1,819
Acquired scoliosis 5 | 281
Breast Neoplasms 5 | 445
Cleft Palate 5 | 271
Colorectal Neoplasms 5 | 243
Curvature of spine 5 | 282
Pick disease 5 | 1,894
colon cancer 5 | 1,478
dermatomyositis 5 | 966
esophageal adenocarcinoma 5 | 737
limb girdle muscular dystrophy 2A 5 | 213
osteoporosis-pseudoglioma syndrome 5 | 9
sonic hedgehog group medulloblastoma 5 | 467
subependymal giant cell astrocytoma 5 | 2,287
Adenoma 4 | 167
Broad flat nasal bridge 4 | 236
Congenital diaphragmatic hernia 4 | 67
Cryptorchidism 4 | 296
Gait abnormality 4 | 135
Heart conduction disease 4 | 83
Juvenile osteoporosis 4 | 4
Kidney disease 4 | 430
Mammary Neoplasms 4 | 425
Nasal bridge wide 4 | 236
Orbital separation excessive 4 | 244
Osteoporosis, Juvenile 4 | 4
Parkinson's disease 4 | 392
Platyspondyly 4 | 56
Prostatic Neoplasms 4 | 495
Rheumatoid arthritis 4 | 1,191
Tooth agenesis 4 | 44
chronic rhinosinusitis 4 | 512
medulloblastoma 4 | 720
nephrosclerosis 4 | 333
non diabetic and post-ischemic heart failure 4 | 200
Arthritis 3 | 290
Bipolar Disorder 3 | 666
Chronic obstructive pulmonary disease 3 | 184
Endometriosis 3 | 540
Hypersensitivity reaction type II disease 3 | 253
Umbilical hernia 3 | 93
Vascular disease 3 | 319
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
fibroadenoma 3 | 559
urothelial carcinoma 3 | 318

Tissue

Female tissues 48 | 17,400
Digestive Tract 47 | 17,369
Endocrine System 47 | 18,159
Nervous System 47 | 16,725
Blood and immune system 46 | 16,909
Male tissues 46 | 17,142
Skin and soft tissues 46 | 17,230
Urinary Tract 45 | 16,678
Liver and Pancreas 43 | 16,750
Respiratory system 41 | 16,393
Cardiovascular System 36 | 15,192

Target Family

Non-IDG 42 | 12,091
Transcription Factor 4 | 1,400
Kinase 2 | 634
Enzyme 1 | 4,145

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Syndecan-3 SDC3 Tbio Non-IDG -1.86172 78.8 179
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46
Protein Wnt-2b WNT2B Tbio Non-IDG -1.76988 58.0 172
Protein Wnt-10a WNT10A Tbio Non-IDG -2.66153 436.3 118
Protein Wnt-5b WNT5B Tbio Non-IDG -1.62833 40.2 161
Secreted frizzled-related protein 3 FRZB Tbio Non-IDG -2.51623 308.4 252
Kremen protein 1 KREMEN1 Tbio Non-IDG -1.25099 14.5 263
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297