Development Level

Tbio 13 | 11,445
Tchem 12 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 81
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Cancer 22 | 2,499
Carcinoma 22 | 11,493
osteosarcoma 21 | 7,950
ovarian cancer 21 | 8,520
glioblastoma 15 | 5,792
lung cancer 15 | 4,740
Breast cancer 13 | 3,578
medulloblastoma, large-cell 13 | 6,241
psoriasis 13 | 6,694
Kidney cancer 12 | 2,613
atypical teratoid / rhabdoid tumor 12 | 5,112
ependymoma 11 | 4,679
group 4 medulloblastoma 11 | 1,855
Byzanthine arch palate 10 | 194
Joint hyperflexibility 10 | 78
Muscle hypotonia 10 | 571
Short stature 10 | 531
Abnormal dermatoglyphic pattern 9 | 24
Acquired scoliosis 9 | 281
Blepharoptosis 9 | 231
Curvature of spine 9 | 282
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Noonan syndrome 9 | 34
Strabismus 9 | 270
invasive ductal carcinoma 9 | 2,951
Delayed bone age 8 | 136
Downward slant of palpebral fissure 8 | 158
Orbital separation excessive 8 | 244
group 3 medulloblastoma 8 | 4,104
juvenile dermatomyositis 8 | 1,187
oligodendroglioma 8 | 2,850
Aortic coarctation 7 | 30
Cardiac Arrhythmia 7 | 103
Cardiac conduction abnormalities 7 | 78
Conduction disorder of the heart 7 | 79
Congenital pectus carinatum 7 | 52
Cryptorchidism 7 | 296
EKG abnormalities 7 | 78
Electrocardiogram abnormal 7 | 81
Electrocardiogram change 7 | 78
Excess nuchal skin 7 | 30
Full lower lip 7 | 64
High forehead 7 | 102
Multiple myeloma 7 | 1,332
Neck webbing 7 | 35
Pectus excavatum 7 | 100
Prominent lower lip 7 | 64
Tall forehead 7 | 102
Triangular face 7 | 58
astrocytic glioma 7 | 2,597
lung adenocarcinoma 7 | 2,716
malignant mesothelioma 7 | 3,232
pancreatic cancer 7 | 2,398
ulcerative colitis 7 | 1,819
Abnormality of pulmonary valve 6 | 23
Bleeding tendency 6 | 37
Blood Coagulation Disorders 6 | 42
Carcinoma, Hepatocellular 6 | 228
Carcinoma, Squamous Cell 6 | 110
Coagulation abnormalities 6 | 27
Coarse hair 6 | 31
Congenital Epicanthus 6 | 177
Curly hair (finding) 6 | 14
Decreased projection of midface 6 | 105
Dysarthria 6 | 192
Enlarged thorax 6 | 18
Exophthalmos 6 | 112
Feeding difficulties in infancy 6 | 175
Hemorrhagic Disorders 6 | 30
Hepatomegaly 6 | 285
Hypogonadism, Isolated Hypogonadotropic 6 | 71
Hypogonadotropic hypogonadism 6 | 89
Hypotrophic midface 6 | 105
Liver carcinoma 6 | 240
Low posterior hairline 6 | 52
Low-set, posteriorly rotated ears 6 | 110
Lymphangioma, Cystic 6 | 21
Melanocytic nevus 6 | 43
Midface retrusion 6 | 105
Muscle Weakness 6 | 170
Neuroblastoma 6 | 80
Noncancerous mole 6 | 28
Prominent eyes 6 | 96
Prominent globes 6 | 96
Protruding eyes 6 | 96
Pulmonary Stenosis 6 | 45
Pulmonary artery stenosis 6 | 22
Rough hair texture 6 | 31
Schizophrenia 6 | 1,160
Short neck 6 | 140
Small midface 6 | 105
Squamous cell carcinoma 6 | 129
Stomach Neoplasms 6 | 300
Wide spaced nipples 6 | 46
adult high grade glioma 6 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
non-small cell lung cancer 6 | 2,890

Tissue

Blood and immune system 30 | 16,909
Cardiovascular System 30 | 15,192
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678

Target Family

Enzyme 12 | 4,145
Non-IDG 11 | 12,091
Kinase 7 | 634

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113
SHC-transforming protein 3 SHC3 Tbio Non-IDG -1.97665 99.4 137
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134