Development Level

Tbio 4 | 11,445
Tchem 3 | 1,598
Tclin 3 | 613

IMPC Phenotype

abnormal brain morphology 1 | 13
decreased circulating glucose ... 1 | 126
decreased total body fat amoun... 1 | 207
increased bone mineral density 1 | 72
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Cancer 9 | 2,499
Carcinoma 9 | 11,493
ovarian cancer 9 | 8,520
lung cancer 8 | 4,740
osteosarcoma 8 | 7,950
ependymoma 7 | 4,679
Kidney cancer 6 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
psoriasis 6 | 6,694
Immune system cancer 5 | 140
Lymphoid leukemia 5 | 160
Rheumatoid arthritis 5 | 1,191
Short stature 5 | 531
glioblastoma 5 | 5,792
medulloblastoma, large-cell 5 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Acquired scoliosis 4 | 281
Anemia 4 | 365
Breast cancer 4 | 3,578
Curvature of spine 4 | 282
Enophthalmos 4 | 75
Frontal bossing 4 | 157
Low set ears 4 | 181
Multiple myeloma 4 | 1,332
Prostatic Neoplasms 4 | 495
Sunken eyes 4 | 63
adult high grade glioma 4 | 3,801
astrocytoma 4 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
pituitary cancer 4 | 1,972
Arthritis 3 | 290
Astrocytoma, Pilocytic 3 | 3,081
Autistic Disorder 3 | 364
Broad flat nasal bridge 3 | 236
Bushy eyebrows 3 | 49
Byzanthine arch palate 3 | 194
Carcinoma, Squamous Cell 3 | 110
Colorectal Neoplasms 3 | 243
Congenital deafness 3 | 185
Crohn's disease 3 | 321
Cryptorchidism 3 | 296
Deafness 3 | 198
Decreased projection of maxilla 3 | 66
Deficiency of upper jaw bones 3 | 66
Dull intelligence 3 | 645
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Feeding difficulties in infancy 3 | 175
Hearing Loss, Partial 3 | 185
Hypoplasia of the maxilla 3 | 66
Hypoplastic iliac wing 3 | 19
Hypoplastic mandible condyle 3 | 275
Hypotrophic maxilla 3 | 66
Intellectual disability 3 | 1,016
Isolated cases 3 | 72
Low intelligence 3 | 645
Mandibular hypoplasia 3 | 275
Maxillary retrognathia 3 | 66
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Micrognathism 3 | 275
Microstomia 3 | 78
Muscle hypotonia 3 | 571
Nasal bridge wide 3 | 236
Obesity 3 | 678
Patent ductus arteriosus 3 | 90
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Polycystic ovary syndrome 3 | 360
Poor school performance 3 | 645
Respiratory distress 3 | 43
Retrusion of upper jaw bones 3 | 66
Schizophrenia 3 | 1,160
Seizures 3 | 596
Single transverse palmar crease 3 | 29
Small head 3 | 374
Squamous cell carcinoma 3 | 129
Stomach Neoplasms 3 | 300
Strabismus 3 | 270
acute quadriplegic myopathy 3 | 1,158
atypical teratoid / rhabdoid tumor 3 | 5,112
group 4 medulloblastoma 3 | 1,855
hearing impairment 3 | 199
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Agoraphobia 2 | 21
Auricular malformation 2 | 41
Broad thumbs 2 | 28
Large foramen magnum 2 | 6
Leukemia, Myelocytic, Acute 2 | 120
Leukemia, Myeloid, Acute 2 | 105
Non-alcoholic Fatty Liver Disease 2 | 42
Ovarian Neoplasms 2 | 102
Poor coordination 2 | 11
Simple ear 2 | 41
Spina bifida occulta 2 | 19
ovarian neoplasm 2 | 99

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Non-IDG 3 | 12,091
Transcription Factor 3 | 1,400
Epigenetic 2 | 242
Kinase 2 | 634

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Leukemia inhibitory factor receptor LIFR Tbio Non-IDG -2.35146 221.3 249
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Tyrosine-protein kinase JAK1 JAK1 Tclin Kinase -2.80024 518.7 425
CREB-binding protein CREBBP Tchem Epigenetic -2.81657 471.6 449
Tyrosine-protein kinase JAK2 JAK2 Tclin Kinase -3.54037 3339.7 801
Mothers against decapentaplegic homolog 1 SMAD1 Tbio Transcription Factor -0.93576 6.90 897