Development Level

Tclin 36 | 613
Tbio 32 | 11,445
Tchem 16 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
abnormal behavior 3 | 298
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
decreased body weight 2 | 161
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
preweaning lethality, complete... 2 | 979
abnormal retinal vasculature m... 1 | 27
abnormal whole-body plethysmog... 1 | 4
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased T cell number 1 | 6
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased cellular hemoglobin ... 1 | 1
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating potassiu... 1 | 29
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
macrophthalmia 1 | 2
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 64 | 11,493
medulloblastoma, large-cell 50 | 6,241
ovarian cancer 49 | 8,520
osteosarcoma 43 | 7,950
atypical teratoid / rhabdoid tumor 36 | 5,112
lung cancer 35 | 4,740
psoriasis 32 | 6,694
glioblastoma 31 | 5,792
ependymoma 30 | 4,679
Breast cancer 25 | 3,578
Autosomal recessive predisposition 24 | 1,442
group 3 medulloblastoma 24 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
invasive ductal carcinoma 24 | 2,951
Astrocytoma, Pilocytic 23 | 3,081
Chronic heart failure 23 | 46
astrocytic glioma 22 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
primitive neuroectodermal tumor 22 | 3,035
Atrial Fibrillation 21 | 124
lung adenocarcinoma 21 | 2,716
non-small cell lung cancer 21 | 2,890
Kidney cancer 19 | 2,613
Myocardial Perfusion Imaging Adjunct 19 | 25
Platelet Aggregation Inhibition 19 | 22
Prevention of Cerebral Thrombosis 19 | 29
adult high grade glioma 19 | 3,801
interstitial cystitis 19 | 2,312
oligodendroglioma 19 | 2,850
colon cancer 18 | 1,478
tuberculosis 18 | 2,010
pancreatic cancer 17 | 2,398
ulcerative colitis 17 | 1,819
lung carcinoma 16 | 2,843
malignant mesothelioma 16 | 3,232
Pick disease 15 | 1,894
group 4 medulloblastoma 15 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
breast carcinoma 13 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Schizophrenia 11 | 1,160
ductal carcinoma in situ 11 | 1,745
pituitary cancer 11 | 1,972
Cancer 10 | 2,499
gastric carcinoma 10 | 807
Intellectual disability 9 | 1,016
Mental Depression 9 | 333
Obesity 9 | 678
subependymal giant cell astrocytoma 9 | 2,287
Bipolar Disorder 8 | 666
Dull intelligence 8 | 645
Dysuria 8 | 26
Increased Urinary Frequency 8 | 11
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Nocturia 8 | 9
Poor school performance 8 | 645
Retinitis Pigmentosa 8 | 226
Suprapubic pain 8 | 8
Urgent desire to urinate 8 | 11
Urinary Incontinence 8 | 50
Urinary Tract Irritation 8 | 24
Waldenstrons macroglobulinemia 8 | 765
diabetes mellitus 8 | 1,728
nasopharyngeal carcinoma 8 | 1,058
pediatric high grade glioma 8 | 1,064
Asthma 7 | 385
Atopic dermatitis 7 | 952
Depressive disorder 7 | 409
Electroretinogram abnormal 7 | 95
Epilepsy 7 | 792
Hypogonadism 7 | 173
Multiple myeloma 7 | 1,332
Nystagmus 7 | 317
Optic Atrophy 7 | 242
Photodysphoria 7 | 121
Photophobia 7 | 121
adrenocortical carcinoma 7 | 1,428
cutaneous lupus erythematosus 7 | 1,057
cystic fibrosis 7 | 1,696
primary pancreatic ductal adenocarcinoma 7 | 1,109
Abnormality of retinal pigmentation 6 | 111
Anteverted nostril 6 | 191
Blindness 6 | 88
Decompensated cardiac failure 6 | 9
Difficulties with night vision 6 | 87
Endometriosis 6 | 540
Night Blindness 6 | 101
Retinal pigment epithelial abnormality 6 | 111
active Crohn's disease 6 | 922
acute quadriplegic myopathy 6 | 1,158
astrocytoma 6 | 1,146
dermatomyositis 6 | 966
pancreatic carcinoma 6 | 562
primary Sjogren syndrome 6 | 735
Rheumatoid arthritis 5 | 1,191
chronic rhinosinusitis 5 | 512
fibroadenoma 5 | 559
progressive supranuclear palsy 5 | 676

Tissue

Endocrine System 83 | 18,159
Blood and immune system 82 | 16,909
Digestive Tract 82 | 17,369
Skin and soft tissues 81 | 17,230
Urinary Tract 81 | 16,678
Female tissues 80 | 17,400
Liver and Pancreas 80 | 16,750
Male tissues 80 | 17,142
Nervous System 79 | 16,725
Respiratory system 79 | 16,393
Cardiovascular System 76 | 15,192

Target Family

Enzyme 74 | 4,145
Kinase 8 | 634
Non-IDG 3 | 12,091

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Adenylate cyclase type 10 ADCY10 Tchem Enzyme -3.13751 1324.4 108
Ectonucleoside triphosphate diphosphohydrolase 2 ENTPD2 Tchem Enzyme -2.37613 245.8 150
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.20658 167.7 205
Bifunctional purine biosynthesis protein PURH ATIC Tchem Non-IDG -2.93014 835.0 246
Cytosolic 5'-nucleotidase 1B NT5C1B Tbio Enzyme -1.94015 85.4 93
AMP deaminase 2 AMPD2 Tchem Enzyme -1.74341 53.6 155
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A Tclin Enzyme -1.27429 21.3 169
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha PDE6A Tclin Enzyme -1.29228 20.3 111
Guanine deaminase GDA Tbio Enzyme -1.48687 32.3 196