Development Level

Tchem 5 | 1,598
Tclin 5 | 613
Tbio 3 | 11,445

IMPC Phenotype

decreased circulating creatini... 2 | 39
decreased body weight 1 | 161
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
preweaning lethality, incomple... 1 | 499

Disease

Cancer 11 | 2,499
Carcinoma 11 | 11,493
medulloblastoma, large-cell 9 | 6,241
osteosarcoma 9 | 7,950
ovarian cancer 9 | 8,520
lung cancer 8 | 4,740
psoriasis 7 | 6,694
Severe combined immunodeficiency 6 | 51
malignant mesothelioma 6 | 3,232
Breast cancer 5 | 3,578
Failure to gain weight 5 | 365
Pediatric failure to thrive 5 | 365
Rheumatoid arthritis 5 | 1,191
adult high grade glioma 5 | 3,801
atypical teratoid / rhabdoid tumor 5 | 5,112
ductal carcinoma in situ 5 | 1,745
glioblastoma 5 | 5,792
group 4 medulloblastoma 5 | 1,855
interstitial cystitis 5 | 2,312
invasive ductal carcinoma 5 | 2,951
pancreatic cancer 5 | 2,398
Autosomal recessive predisposition 4 | 1,442
Kidney cancer 4 | 2,613
Polycythemia vera 4 | 27
Schizophrenia 4 | 1,160
Splenomegaly 4 | 190
pituitary cancer 4 | 1,972
Anemia 3 | 365
Diarrhea 3 | 253
Diffuse large B-cell lymphoma 3 | 39
Fever 3 | 138
Frontal bossing 3 | 157
Lymphadenopathy 3 | 62
Lymphoma, Large B-Cell, Diffuse 3 | 34
Lymphopenia 3 | 67
Multiple Sclerosis 3 | 540
Pneumonia 3 | 174
Prostatic Neoplasms 3 | 495
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
follicular lymphoma 3 | 20
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
pancreatic carcinoma 3 | 562
primitive neuroectodermal tumor 3 | 3,035
ulcerative colitis 3 | 1,819
Absence of eyebrows 2 | 31
Alopecia 2 | 115
Animal Mammary Neoplasms 2 | 136
Aplasia/Hypoplasia of the eyebrow 2 | 31
Atopic dermatitis 2 | 952
Big calvaria 2 | 147
Breast Neoplasms 2 | 445
Concave bridge of nose 2 | 195
DOID:2627 2 | 94
Decreased antibody level in blood 2 | 35
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Dry skin 2 | 75
Endometrial cancer 2 | 311
Endometriosis 2 | 540
Epilepsy 2 | 792
Fatigue 2 | 182
Hepatomegaly 2 | 285
High forehead 2 | 102
Hypersensitivity reaction type II disease 2 | 253
Hypogammaglobulinemia 2 | 35
Immunologic Deficiency Syndromes 2 | 113
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Leukemia 2 | 104
Liver Cirrhosis, Experimental 2 | 769
Liver cancer 2 | 604
Lung Neoplasms 2 | 232
Lymphoid leukemia 2 | 160
Mammary Neoplasms 2 | 425
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Mastocytosis 2 | 27
Microstomia 2 | 78
Myopia 2 | 176
Otitis Media 2 | 52
Polymicrogyria 2 | 48
Pruritus 2 | 58
Seizures 2 | 596
Sparse or absent eyebrows 2 | 31
Sparse/absent eyebrows 2 | 31
Tall forehead 2 | 102
Telecanthus 2 | 62
Ventricular Septal Defects 2 | 119
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
non-small cell lung cancer 2 | 2,890
sarcoidosis 2 | 370
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Kinase 6 | 634
Non-IDG 4 | 12,091
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 13 | 13
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
Interleukin-7 receptor subunit alpha IL7R Tbio Non-IDG -2.77688 547.0 828
Signal transducer and activator of transcription 5B STAT5B Tchem Transcription Factor -3.02570 950.5 620
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Interleukin-7 IL7 Tbio Non-IDG -3.06671 1222.2 599
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform PIK3CB Tchem Kinase -2.29043 197.8 384
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA Tclin Kinase -3.04988 1076.8 484
Tyrosine-protein kinase JAK1 JAK1 Tclin Kinase -2.80024 518.7 425
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform PIK3CD Tclin Kinase -2.85064 709.2 423