Development Level

Tchem 8 | 1,598
Tbio 4 | 11,445
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
enlarged heart 1 | 210
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Cancer 12 | 2,499
Carcinoma 12 | 11,493
ovarian cancer 12 | 8,520
lung cancer 10 | 4,740
glioblastoma 9 | 5,792
osteosarcoma 9 | 7,950
Breast cancer 8 | 3,578
Hepatomegaly 8 | 285
Blepharoptosis 7 | 231
Cryptorchidism 7 | 296
Delayed bone age 7 | 136
Downward slant of palpebral fissure 7 | 158
Dysarthria 7 | 192
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
group 3 medulloblastoma 7 | 4,104
malignant mesothelioma 7 | 3,232
medulloblastoma, large-cell 7 | 6,241
Abnormal dermatoglyphic pattern 6 | 24
Byzanthine arch palate 6 | 194
Cardiac Arrhythmia 6 | 103
Cardiac conduction abnormalities 6 | 78
Conduction disorder of the heart 6 | 79
Congenital pectus carinatum 6 | 52
Curly hair (finding) 6 | 14
Decreased projection of midface 6 | 105
EKG abnormalities 6 | 78
Electrocardiogram abnormal 6 | 81
Electrocardiogram change 6 | 78
Excess nuchal skin 6 | 30
Exophthalmos 6 | 112
Full lower lip 6 | 64
Hypogonadism, Isolated Hypogonadotropic 6 | 71
Hypogonadotropic hypogonadism 6 | 89
Hypotrophic midface 6 | 105
Joint hyperflexibility 6 | 78
Kidney cancer 6 | 2,613
Midface retrusion 6 | 105
Muscle hypotonia 6 | 571
Neck webbing 6 | 35
Noonan syndrome 6 | 34
Orbital separation excessive 6 | 244
Prominent eyes 6 | 96
Prominent globes 6 | 96
Prominent lower lip 6 | 64
Protruding eyes 6 | 96
Short stature 6 | 531
Small midface 6 | 105
Strabismus 6 | 270
astrocytic glioma 6 | 2,597
psoriasis 6 | 6,694
Abnormal hair quantity 5 | 16
Abnormal platelet function 5 | 12
Abnormality of pulmonary valve 5 | 23
Abnormality of the spleen 5 | 13
Acquired scoliosis 5 | 281
Aplasia/Hypoplasia of the abdominal wall musculature 5 | 17
Bleeding tendency 5 | 37
Blood Coagulation Disorders 5 | 42
Breast Neoplasms 5 | 445
Coagulation abnormalities 5 | 27
Coarse hair 5 | 31
Curvature of spine 5 | 282
Enlarged thorax 5 | 18
Epilepsy 5 | 792
Feeding difficulties in infancy 5 | 175
Hemorrhagic Disorders 5 | 30
High forehead 5 | 102
Hyperreflexia 5 | 209
Low posterior hairline 5 | 52
Low-set, posteriorly rotated ears 5 | 110
Lymphangioma, Cystic 5 | 21
Mammary Neoplasms 5 | 425
Muscle Weakness 5 | 170
Pectus excavatum 5 | 100
Pulmonary Stenosis 5 | 45
Pulmonary artery stenosis 5 | 22
Rough hair texture 5 | 31
Seizures 5 | 596
Short neck 5 | 140
Tall forehead 5 | 102
Thickened helices 5 | 15
Triangular face 5 | 58
Wide spaced nipples 5 | 46
atypical teratoid / rhabdoid tumor 5 | 5,112
cystic fibrosis 5 | 1,696
juvenile dermatomyositis 5 | 1,187
pancreatic cancer 5 | 2,398
Concave bridge of nose 4 | 195
Congenital Epicanthus 4 | 177
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Multiple myeloma 4 | 1,332
Stomach Neoplasms 4 | 300
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
oligodendroglioma 4 | 2,850
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Non-IDG 8 | 12,091
Kinase 4 | 634
Enzyme 3 | 4,145

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 15 | 15
http://pathwaycommons.org/pc2/... 236 | 236
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113
SHC-transforming protein 3 SHC3 Tbio Non-IDG -1.97665 99.4 137
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
Platelet-derived growth factor subunit A PDGFA Tchem Non-IDG -2.74845 537.8 341
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147