Development Level

Tbio 13 | 11,445
Tchem 5 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
abnormal spleen morphology 1 | 55
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased threshold for audito... 1 | 26
embryonic lethality prior to t... 1 | 278
increased B cell number 1 | 9
increased T cell number 1 | 6
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased lactate dehydrogenas... 1 | 3
increased startle reflex 1 | 112
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
thick ventricular wall 1 | 7

Disease

Carcinoma 19 | 11,493
osteosarcoma 16 | 7,950
ovarian cancer 16 | 8,520
Cancer 15 | 2,499
glioblastoma 13 | 5,792
lung cancer 12 | 4,740
Breast cancer 9 | 3,578
ependymoma 9 | 4,679
Blepharoptosis 8 | 231
Cryptorchidism 8 | 296
Downward slant of palpebral fissure 8 | 158
Orbital separation excessive 8 | 244
Short stature 8 | 531
Strabismus 8 | 270
atypical teratoid / rhabdoid tumor 8 | 5,112
medulloblastoma, large-cell 8 | 6,241
pancreatic cancer 8 | 2,398
psoriasis 8 | 6,694
Abnormal dermatoglyphic pattern 7 | 24
Byzanthine arch palate 7 | 194
Cardiac Arrhythmia 7 | 103
Cardiac conduction abnormalities 7 | 78
Conduction disorder of the heart 7 | 79
Congenital pectus carinatum 7 | 52
Curly hair (finding) 7 | 14
Delayed bone age 7 | 136
EKG abnormalities 7 | 78
Electrocardiogram abnormal 7 | 81
Electrocardiogram change 7 | 78
Excess nuchal skin 7 | 30
Feeding difficulties in infancy 7 | 175
Full lower lip 7 | 64
High forehead 7 | 102
Hypoplastic mandible condyle 7 | 275
Joint hyperflexibility 7 | 78
Kidney cancer 7 | 2,613
Low-set, posteriorly rotated ears 7 | 110
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Muscle hypotonia 7 | 571
Neck webbing 7 | 35
Noonan syndrome 7 | 34
Prominent lower lip 7 | 64
Short neck 7 | 140
Tall forehead 7 | 102
astrocytic glioma 7 | 2,597
primary pancreatic ductal adenocarcinoma 7 | 1,109
Abnormal hair quantity 6 | 16
Abnormal platelet function 6 | 12
Abnormality of pulmonary valve 6 | 23
Abnormality of the spleen 6 | 13
Acquired scoliosis 6 | 281
Aplasia/Hypoplasia of the abdominal wall musculature 6 | 17
Astrocytoma, Pilocytic 6 | 3,081
Bleeding tendency 6 | 37
Blood Coagulation Disorders 6 | 42
Breast Neoplasms 6 | 445
Coagulation abnormalities 6 | 27
Coarse hair 6 | 31
Congenital Epicanthus 6 | 177
Curvature of spine 6 | 282
Decreased projection of midface 6 | 105
Dysarthria 6 | 192
Enlarged thorax 6 | 18
Exophthalmos 6 | 112
Hemorrhagic Disorders 6 | 30
Hepatomegaly 6 | 285
Hypogonadism, Isolated Hypogonadotropic 6 | 71
Hypogonadotropic hypogonadism 6 | 89
Hypotrophic midface 6 | 105
Low posterior hairline 6 | 52
Lymphangioma, Cystic 6 | 21
Mammary Neoplasms 6 | 425
Midface retrusion 6 | 105
Muscle Weakness 6 | 170
Pectus excavatum 6 | 100
Prominent eyes 6 | 96
Prominent globes 6 | 96
Protruding eyes 6 | 96
Pulmonary Stenosis 6 | 45
Pulmonary artery stenosis 6 | 22
Rough hair texture 6 | 31
Small midface 6 | 105
Thickened helices 6 | 15
Triangular face 6 | 58
Wide spaced nipples 6 | 46
juvenile dermatomyositis 6 | 1,187
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Mental and motor retardation 5 | 608
Multiple myeloma 5 | 1,332
Poor school performance 5 | 645
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819

Tissue

Blood and immune system 20 | 16,909
Cardiovascular System 20 | 15,192
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678

Target Family

Transcription Factor 10 | 1,400
Non-IDG 4 | 12,091
Enzyme 3 | 4,145
Kinase 3 | 634

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Friend leukemia integration 1 transcription factor FLI1 Tbio Transcription Factor -1.82504 66.8 454
ETS domain-containing protein Elk-3 ELK3 Tbio Transcription Factor -0.17124 0.86 225
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.92119 9.61 156
ETS domain-containing protein Elk-4 ELK4 Tbio Transcription Factor -1.07328 11.4 100
Transcriptional regulator ERG ERG Tchem Transcription Factor -1.19111 12.3 398
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134