Development Level

Tchem 16 | 1,598
Tbio 9 | 11,445
Tclin 4 | 613

IMPC Phenotype

decreased body length 2 | 101
decreased bone mineral density 2 | 126
embryonic lethality prior to o... 2 | 239
male infertility 2 | 123
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating potassiu... 1 | 20
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased cardiac muscle contr... 1 | 8
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134

Disease

Carcinoma 23 | 11,493
psoriasis 18 | 6,694
ovarian cancer 16 | 8,520
lung cancer 14 | 4,740
Cancer 12 | 2,499
medulloblastoma, large-cell 12 | 6,241
osteosarcoma 11 | 7,950
invasive ductal carcinoma 10 | 2,951
pituitary cancer 10 | 1,972
Intellectual disability 9 | 1,016
Seizures 9 | 596
glioblastoma 9 | 5,792
interstitial cystitis 9 | 2,312
lung adenocarcinoma 9 | 2,716
pancreatic cancer 9 | 2,398
Dull intelligence 8 | 645
Epilepsy 8 | 792
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
acute myeloid leukemia 8 | 783
atypical teratoid / rhabdoid tumor 8 | 5,112
colon cancer 8 | 1,478
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
Autosomal recessive predisposition 7 | 1,442
Breast cancer 7 | 3,578
Depressive disorder 7 | 409
diabetes mellitus 7 | 1,728
ductal carcinoma in situ 7 | 1,745
esophageal adenocarcinoma 7 | 737
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung carcinoma 7 | 2,843
non-small cell lung cancer 7 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
primitive neuroectodermal tumor 7 | 3,035
Asthma 6 | 385
Bipolar Disorder 6 | 666
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Hypertension 6 | 396
Liver Cirrhosis, Experimental 6 | 769
Mental and motor retardation 6 | 608
Succinic semialdehyde dehydrogenase deficiency 6 | 16
adult high grade glioma 6 | 3,801
breast carcinoma 6 | 1,638
malignant mesothelioma 6 | 3,232
Alcohol dependence 5 | 107
Alcoholic Intoxication, Chronic 5 | 289
Atopic dermatitis 5 | 952
Duchenne muscular dystrophy 5 | 601
Schizophrenia 5 | 1,160
nephrosclerosis 5 | 333
oligodendroglioma 5 | 2,850
pediatric high grade glioma 5 | 1,064
primary pancreatic ductal adenocarcinoma 5 | 1,109
ulcerative colitis 5 | 1,819
Brain disease 4 | 96
Colonic Neoplasms 4 | 142
Hypertensive disease 4 | 292
Kidney disease 4 | 430
Leishmaniasis 4 | 47
Mental Depression 4 | 333
Mood Disorders 4 | 184
X- linked recessive 4 | 110
acute quadriplegic myopathy 4 | 1,158
astrocytoma 4 | 1,146
chronic rhinosinusitis 4 | 512
fibroadenoma 4 | 559
group 4 medulloblastoma 4 | 1,855
Alzheimer's disease 3 | 658
Astrocytoma, Pilocytic 3 | 3,081
Atherosclerosis 3 | 291
Attention deficit hyperactivity disorder 3 | 278
Autistic Disorder 3 | 364
Brain Ischemia 3 | 110
Cerebrovascular disease 3 | 238
Coronary artery disease 3 | 268
Dysarthria 3 | 192
Endometriosis 3 | 540
Kidney cancer 3 | 2,613
Major Depressive Disorder 3 | 301
Multiple myeloma 3 | 1,332
Status Epilepticus 3 | 98
Toxic encephalopathy 3 | 141
Unipolar Depression 3 | 250
Vascular disease 3 | 319
Vomiting 3 | 116
active Crohn's disease 3 | 922
adrenocortical carcinoma 3 | 1,428
astrocytic glioma 3 | 2,597
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
spina bifida 3 | 1,074
tuberculosis 3 | 2,010

Tissue

Blood and immune system 29 | 16,909
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Nervous System 29 | 16,725
Respiratory system 29 | 16,393
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678
Male tissues 28 | 17,142
Cardiovascular System 27 | 15,192

Target Family

Enzyme 29 | 4,145

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Arginase-2, mitochondrial ARG2 Tchem Enzyme -2.46702 275.2 245
S-adenosylmethionine decarboxylase proenzyme AMD1 Tchem Enzyme -3.21826 1586.8 141
Spermine synthase SMS Tchem Enzyme -1.50353 28.6 215
4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 Tbio Enzyme -1.43954 27.0 162
Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 Tbio Enzyme -3.14670 1303.9 150
Amine oxidase [flavin-containing] B MAOB Tclin Enzyme -3.40865 2530.3 252
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.35134 2277.5 752
Spermidine synthase SRM Tchem Enzyme -1.65951 38.0 172
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 Tbio Enzyme -1.74725 52.8 197
Retinal dehydrogenase 1 ALDH1A1 Tchem Enzyme -2.81062 648.3 725