Development Level

Tbio 39 | 11,445
Tchem 7 | 1,598
Tdark 1 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal heart morphology 4 | 162
decreased vertical activity 3 | 208
enlarged heart 3 | 210
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
decreased lymphocyte cell numb... 2 | 83
decreased startle reflex 2 | 75
edema 2 | 59
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
hydrometra 2 | 53
small superior vagus ganglion 2 | 74
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal craniofacial morpholo... 1 | 33
abnormal eye size 1 | 7
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
hydroencephaly 1 | 14
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating insulin ... 1 | 3
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small heart 1 | 10
syndactyly 1 | 23

Disease

Carcinoma 38 | 11,493
psoriasis 25 | 6,694
osteosarcoma 22 | 7,950
Cancer 21 | 2,499
ovarian cancer 21 | 8,520
Breast cancer 19 | 3,578
atypical teratoid / rhabdoid tumor 19 | 5,112
ependymoma 16 | 4,679
lung cancer 16 | 4,740
interstitial cystitis 14 | 2,312
medulloblastoma, large-cell 14 | 6,241
glioblastoma 13 | 5,792
group 3 medulloblastoma 13 | 4,104
primitive neuroectodermal tumor 12 | 3,035
Kidney cancer 11 | 2,613
breast carcinoma 11 | 1,638
invasive ductal carcinoma 11 | 2,951
malignant mesothelioma 11 | 3,232
ductal carcinoma in situ 10 | 1,745
lung carcinoma 10 | 2,843
Astrocytoma, Pilocytic 9 | 3,081
cystic fibrosis 9 | 1,696
non-small cell lung cancer 9 | 2,890
Osteoporosis 8 | 363
Short stature 8 | 531
astrocytic glioma 8 | 2,597
Autosomal recessive predisposition 7 | 1,442
Bipolar Disorder 7 | 666
Cryptorchidism 7 | 296
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Schizophrenia 7 | 1,160
acute myeloid leukemia 7 | 783
colon cancer 7 | 1,478
oligodendroglioma 7 | 2,850
pancreatic cancer 7 | 2,398
pediatric high grade glioma 7 | 1,064
Dull intelligence 6 | 645
Intellectual disability 6 | 1,016
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Obesity 6 | 678
Poor school performance 6 | 645
Small head 6 | 374
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
pituitary cancer 6 | 1,972
Breast Neoplasms 5 | 445
Broad flat nasal bridge 5 | 236
Cognitive delay 5 | 608
Decreased projection of maxilla 5 | 66
Deficiency of upper jaw bones 5 | 66
Global developmental delay 5 | 608
Hypoplasia of the maxilla 5 | 66
Hypotrophic maxilla 5 | 66
Low set ears 5 | 181
Maxillary retrognathia 5 | 66
Mental and motor retardation 5 | 608
Muscle hypotonia 5 | 571
Nasal bridge wide 5 | 236
Retrusion of upper jaw bones 5 | 66
Strabismus 5 | 270
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
cutaneous lupus erythematosus 5 | 1,057
esophageal adenocarcinoma 5 | 737
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
lung adenocarcinoma 5 | 2,716
non primary Sjogren syndrome sicca 5 | 891
osteoporosis-pseudoglioma syndrome 5 | 9
tuberculosis 5 | 2,010
Acquired scoliosis 4 | 281
Autistic Disorder 4 | 364
Cataract 4 | 297
Colonic Neoplasms 4 | 142
Curvature of spine 4 | 282
Deafness 4 | 198
Endometrial cancer 4 | 311
Epilepsy 4 | 792
Frontal bossing 4 | 157
Hearing Loss, Partial 4 | 185
Immune system cancer 4 | 140
Lens Opacities 4 | 231
Microstomia 4 | 78
Orbital separation excessive 4 | 244
Penile hypospadias 4 | 106
Pick disease 4 | 1,894
Prostatic Neoplasms 4 | 495
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Vascular disease 4 | 319
Ventricular Septal Defects 4 | 119
acute quadriplegic myopathy 4 | 1,158
fibroadenoma 4 | 559
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
posterior fossa group A ependymoma 4 | 468
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819

Tissue

Female tissues 46 | 17,400
Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Nervous System 45 | 16,725
Blood and immune system 44 | 16,909
Male tissues 44 | 17,142
Skin and soft tissues 44 | 17,230
Urinary Tract 43 | 16,678
Liver and Pancreas 41 | 16,750
Respiratory system 40 | 16,393
Cardiovascular System 36 | 15,192

Target Family

Non-IDG 27 | 12,091
GPCR 10 | 408
Epigenetic 5 | 242
Transcription Factor 5 | 1,400

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Protein Wnt-2b WNT2B Tbio Non-IDG -1.76988 58.0 172
Frizzled-8 FZD8 Tbio GPCR -1.64874 42.5 233
Protein Wnt-5b WNT5B Tbio Non-IDG -1.62833 40.2 161
Frizzled-9 FZD9 Tbio GPCR -1.77240 61.8 380
Protein Wnt-10a WNT10A Tbio Non-IDG -2.66153 436.3 118
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46
Frizzled-6 FZD6 Tbio GPCR -1.63747 44.5 260