Development Level

Tbio 12 | 11,445
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45

Disease

Carcinoma 16 | 11,493
Cancer 15 | 2,499
osteosarcoma 12 | 7,950
ovarian cancer 12 | 8,520
lung cancer 11 | 4,740
Multiple myeloma 10 | 1,332
glioblastoma 10 | 5,792
psoriasis 10 | 6,694
Peripheral T-cell lymphoma 9 | 25
Primary cutaneous T-cell lymphoma 9 | 29
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
subependymal giant cell astrocytoma 8 | 2,287
atypical teratoid / rhabdoid tumor 7 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
medulloblastoma, large-cell 7 | 6,241
tuberculosis 7 | 2,010
Breast cancer 6 | 3,578
Mental Depression 6 | 333
Schizophrenia 6 | 1,160
astrocytoma 6 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
malignant mesothelioma 6 | 3,232
oligodendroglioma 6 | 2,850
primitive neuroectodermal tumor 6 | 3,035
Kidney cancer 5 | 2,613
acute quadriplegic myopathy 5 | 1,158
cystic fibrosis 5 | 1,696
interstitial cystitis 5 | 2,312
invasive ductal carcinoma 5 | 2,951
Amyotrophic lateral sclerosis 4 | 451
Astrocytoma, Pilocytic 4 | 3,081
Craniofacial Abnormalities 4 | 151
Depressive disorder 4 | 409
Familial primary pulmonary hypertension 4 | 11
Intellectual disability 4 | 1,016
Pick disease 4 | 1,894
adult high grade glioma 4 | 3,801
group 4 medulloblastoma 4 | 1,855
lung carcinoma 4 | 2,843
Brachydactyly 3 | 156
Cocaine-Related Disorders 3 | 92
Congenital Camptodactyly 3 | 40
Decreased projection of midface 3 | 105
Dull intelligence 3 | 645
Enophthalmos 3 | 75
Epilepsy 3 | 792
Frontal bossing 3 | 157
Hypoplastic feet 3 | 66
Hypotrophic midface 3 | 105
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Midface retrusion 3 | 105
Mood Disorders 3 | 184
Orbital separation excessive 3 | 244
Poor school performance 3 | 645
Pulmonary Fibrosis 3 | 106
Seizures 3 | 596
Short stature 3 | 531
Small head 3 | 374
Small midface 3 | 105
Sunken eyes 3 | 63
Umbilical hernia 3 | 93
Ureteral obstruction 3 | 33
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 922
acute myeloid leukemia 3 | 783
astrocytic glioma 3 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
juvenile dermatomyositis 3 | 1,187
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
Acquired scoliosis 2 | 281
Anteverted nostril 2 | 191
Bilateral fifth finger clinodactyly 2 | 110
Concave bridge of nose 2 | 195
Curvature of little finger 2 | 110
Curvature of spine 2 | 282
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Endometriosis 2 | 540
Failure to gain weight 2 | 365
Kidney disease 2 | 430
Melanoma 2 | 711
Pediatric failure to thrive 2 | 365
Strabismus 2 | 270
Unipolar Depression 2 | 250
Vascular disease 2 | 319
chronic lymphosyte leukemia 2 | 204
dermatomyositis 2 | 966
medulloblastoma 2 | 720
pulmonary arterial hypertension 2 | 75

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678

Target Family

Epigenetic 9 | 242
Non-IDG 6 | 12,091
Transcription Factor 6 | 1,400

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 21 | 21
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mothers against decapentaplegic homolog 3 SMAD3 Tbio Transcription Factor -3.19667 1403.6 1526
Mothers against decapentaplegic homolog 2 SMAD2 Tbio Transcription Factor -3.26675 1515.7 1396
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Mothers against decapentaplegic homolog 1 SMAD1 Tbio Transcription Factor -0.93576 6.90 897
Histone deacetylase 4 HDAC4 Tclin Epigenetic -2.42231 255.5 825
Histone deacetylase 6 HDAC6 Tclin Epigenetic -2.72354 545.3 725
Histone deacetylase 2 HDAC2 Tclin Epigenetic -2.79651 587.9 712
Histone deacetylase 3 HDAC3 Tclin Epigenetic -2.28457 142.9 673
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.19942 147.5 520