Development Level

Tchem 6 | 1,598
Tbio 4 | 11,445
Tclin 2 | 613

IMPC Phenotype

abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal skin morphology 1 | 50
decreased body weight 1 | 161
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
enlarged kidney 1 | 14
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
preweaning lethality, complete... 1 | 979

Disease

Cancer 10 | 2,499
ovarian cancer 9 | 8,520
Carcinoma 8 | 11,493
glioblastoma 8 | 5,792
psoriasis 8 | 6,694
Vascular disease 7 | 319
atypical teratoid / rhabdoid tumor 7 | 5,112
Cholestasis, Extrahepatic 6 | 25
Lung Neoplasms 6 | 232
medulloblastoma, large-cell 6 | 6,241
Arthritis 5 | 290
Arthritis, Juvenile 5 | 126
Brain Ischemia 5 | 110
Breast cancer 5 | 3,578
Disease Models, Animal 5 | 155
Dull intelligence 5 | 645
Hyperalgesia 5 | 83
Intellectual disability 5 | 1,016
Juvenile arthritis 5 | 126
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Parkinson's disease 5 | 392
Poor school performance 5 | 645
Schizophrenia 5 | 1,160
Trigeminal Neuralgia 5 | 24
lung cancer 5 | 4,740
osteosarcoma 5 | 7,950
pituitary cancer 5 | 1,972
primitive neuroectodermal tumor 5 | 3,035
Alzheimer's disease 4 | 658
Cocaine-Related Disorders 4 | 92
Epilepsy 4 | 792
Eye disease 4 | 62
Kidney disease 4 | 430
Obesity 4 | 678
Reperfusion Injury 4 | 86
Stomach Neoplasms 4 | 300
Toxic encephalopathy 4 | 141
acute myeloid leukemia 4 | 783
aldosterone-producing adenoma 4 | 665
diabetes mellitus 4 | 1,728
ependymoma 4 | 4,679
gastric cancer 4 | 459
group 3 medulloblastoma 4 | 4,104
group 4 medulloblastoma 4 | 1,855
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung carcinoma 4 | 2,843
Asthma 3 | 385
Astrocytoma, Pilocytic 3 | 3,081
Cell Transformation, Neoplastic 3 | 97
Cognitive delay 3 | 608
Depressive disorder 3 | 409
Gastrointestinal system disease 3 | 54
Global developmental delay 3 | 608
Heart disease 3 | 306
Hyperglycemia 3 | 137
Hyperhidrosis disorder 3 | 81
Hypertrophic Cardiomyopathy 3 | 117
Increased sweating 3 | 81
Lung disease 3 | 142
Mental Depression 3 | 333
Mental and motor retardation 3 | 608
Neoplasm Metastasis 3 | 168
Pick disease 3 | 1,894
Premature Birth 3 | 77
Premature birth of newborn 3 | 67
Rheumatoid arthritis 3 | 1,191
Short stature 3 | 531
Substance Withdrawal Syndrome 3 | 55
Sweating 3 | 81
Waldenstrons macroglobulinemia 3 | 765
adrenocortical carcinoma 3 | 1,428
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
chronic lymphosyte leukemia 3 | 204
colon cancer 3 | 1,478
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
nephrosclerosis 3 | 333
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pterygium 3 | 76
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Big calvaria 2 | 147
Coarse facial features 2 | 108
High forehead 2 | 102
Ichthyoses 2 | 41
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Tall forehead 2 | 102
Thickened facial skin with coarse facial features 2 | 108
Underdeveloped brows 2 | 38
Underdeveloped supraorbital ridges 2 | 38

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Kinase 7 | 634
Transcription Factor 5 | 1,400

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Fos-related antigen 1 FOSL1 Tbio Transcription Factor -2.39870 235.8 243
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.29568 193.3 384
Fos-related antigen 2 FOSL2 Tbio Transcription Factor -2.16948 129.6 430
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Protein fosB FOSB Tbio Transcription Factor -2.66286 432.2 328
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 Tclin Kinase -1.83744 60.9 883
Transcription factor AP-1 JUN Tchem Transcription Factor -3.83935 6236.4 2664