Development Level

Tbio 175 | 11,445
Tchem 36 | 1,598
Tclin 19 | 613
Tdark 3 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 17 | 979
decreased vertical activity 8 | 208
enlarged heart 8 | 210
embryonic lethality prior to t... 7 | 278
preweaning lethality, incomple... 6 | 499
abnormal heart morphology 5 | 162
increased total body fat amoun... 5 | 134
decreased bone mineral content 4 | 151
decreased lean body mass 4 | 135
improved glucose tolerance 4 | 79
limb grasping 4 | 41
abnormal bone structure 3 | 187
cataract 3 | 92
decreased body weight 3 | 161
decreased fasted circulating g... 3 | 65
embryonic lethality prior to o... 3 | 239
impaired glucose tolerance 3 | 75
impaired pupillary reflex 3 | 26
increased circulating choleste... 3 | 66
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
increased startle reflex 3 | 112
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
abnormal retinal vasculature m... 2 | 27
corneal opacity 2 | 32
decreased bone mineral density 2 | 126
decreased circulating creatini... 2 | 39
decreased startle reflex 2 | 75
edema 2 | 59
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired righting response 2 | 26
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating iron lev... 2 | 30
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased heart weight 2 | 62
increased leukocyte cell numbe... 2 | 47
increased neutrophil cell numb... 2 | 46
microphthalmia 2 | 26
short tibia 2 | 97
abnormal body wall morphology 1 | 9
abnormal brain morphology 1 | 13
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal whole-body plethysmog... 1 | 4
absent startle reflex 1 | 24
cleft palate 1 | 8
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
female infertility 1 | 60
hemorrhage 1 | 23
hydroencephaly 1 | 14
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased large unstained cell... 1 | 5
increased mean platelet volume 1 | 45
iris synechia 1 | 3
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prolonged RR interval 1 | 8
small superior vagus ganglion 1 | 74
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 120 | 11,493
Cancer 117 | 2,499
psoriasis 103 | 6,694
lung cancer 73 | 4,740
osteosarcoma 66 | 7,950
ovarian cancer 65 | 8,520
glioblastoma 63 | 5,792
ependymoma 62 | 4,679
Schizophrenia 60 | 1,160
diabetes mellitus 60 | 1,728
malignant mesothelioma 58 | 3,232
medulloblastoma, large-cell 58 | 6,241
atypical teratoid / rhabdoid tumor 55 | 5,112
Breast cancer 52 | 3,578
Astrocytoma, Pilocytic 50 | 3,081
group 3 medulloblastoma 49 | 4,104
lung carcinoma 49 | 2,843
interstitial cystitis 47 | 2,312
Depressive disorder 45 | 409
Obesity 44 | 678
Asthma 42 | 385
Bipolar Disorder 42 | 666
Kidney disease 42 | 430
adult high grade glioma 42 | 3,801
Hypertension 40 | 396
oligodendroglioma 39 | 2,850
Autosomal recessive predisposition 38 | 1,442
Mental Depression 38 | 333
cystic fibrosis 38 | 1,696
pituitary cancer 37 | 1,972
ulcerative colitis 35 | 1,819
Alcoholic Intoxication, Chronic 34 | 289
invasive ductal carcinoma 34 | 2,951
lung adenocarcinoma 34 | 2,716
non-small cell lung cancer 34 | 2,890
tuberculosis 34 | 2,010
Major Depressive Disorder 33 | 301
Arthritis 32 | 290
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
Osteoporosis 31 | 363
astrocytic glioma 31 | 2,597
Hypertensive disease 30 | 292
Liver Cirrhosis, Experimental 30 | 769
Unipolar Depression 30 | 250
primitive neuroectodermal tumor 30 | 3,035
colon cancer 29 | 1,478
pancreatic cancer 29 | 2,398
Autistic Disorder 28 | 364
Breast Neoplasms 28 | 445
Diarrhea 28 | 253
Heart disease 28 | 306
Inflammatory bowel disease 28 | 151
Mammary Neoplasms 28 | 425
Anemia 27 | 365
Hypersensitivity reaction type II disease 27 | 253
Rheumatoid arthritis 27 | 1,191
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
Hypotension 26 | 82
Mood Disorders 26 | 184
Pulmonary Fibrosis 26 | 106
Cerebrovascular disease 25 | 238
Inflammation 25 | 120
Lung disease 25 | 142
Multiple Sclerosis 25 | 540
Seizures 25 | 596
Alzheimer's disease 24 | 658
Atherosclerosis 24 | 291
Parkinson's disease 24 | 392
Adenoma 23 | 167
Coronary artery disease 23 | 268
breast carcinoma 23 | 1,638
cutaneous lupus erythematosus 23 | 1,057
Endometriosis 22 | 540
Hypoglycemia 22 | 152
Pain 22 | 103
Polycystic ovary syndrome 22 | 360
Prostatic Neoplasms 22 | 495
Vascular disease 22 | 319
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
Allergic hypersensitivity disease 21 | 126
Hyperglycemia 21 | 137
Kidney cancer 21 | 2,613
Liver disease 21 | 237
Neuropathy 21 | 261
ductal carcinoma in situ 21 | 1,745
Cleft Palate 20 | 271
Infertility 20 | 188
Dermatitis 19 | 157
Epilepsy 19 | 792
Hyperalgesia 19 | 83
Melanoma 19 | 711
Pancreatitis 19 | 123
Reperfusion Injury 19 | 86
Acromegaly 18 | 51
Heart failure 18 | 162
Hypothyroidism 18 | 122
group 4 medulloblastoma 18 | 1,855
subependymal giant cell astrocytoma 18 | 2,287
Allergic rhinitis 17 | 94
Spontaneous abortion 17 | 113

Tissue

Endocrine System 213 | 18,159
Female tissues 203 | 17,400
Digestive Tract 202 | 17,369
Skin and soft tissues 197 | 17,230
Blood and immune system 193 | 16,909
Nervous System 192 | 16,725
Male tissues 190 | 17,142
Liver and Pancreas 188 | 16,750
Urinary Tract 188 | 16,678
Respiratory system 184 | 16,393
Cardiovascular System 146 | 15,192

Target Family

Non-IDG 191 | 12,091
GPCR 31 | 408
Enzyme 11 | 4,145

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thrombopoietin THPO Tbio Non-IDG -3.23551 1632.3 440
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Adenylate cyclase type 10 ADCY10 Tchem Enzyme -3.13751 1324.4 108
Growth/differentiation factor 2 GDF2 Tbio Non-IDG -2.16825 176.4 239
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150