Development Level

Tbio 36 | 11,445
Tchem 15 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal embryo size 3 | 220
abnormal bone structure 2 | 187
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
decreased B cell number 1 | 5
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating creatini... 1 | 39
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased startle reflex 1 | 75
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 42 | 11,493
ovarian cancer 31 | 8,520
osteosarcoma 26 | 7,950
Cancer 23 | 2,499
psoriasis 23 | 6,694
lung cancer 20 | 4,740
Breast cancer 19 | 3,578
atypical teratoid / rhabdoid tumor 18 | 5,112
glioblastoma 18 | 5,792
ependymoma 16 | 4,679
medulloblastoma, large-cell 16 | 6,241
group 3 medulloblastoma 15 | 4,104
Astrocytoma, Pilocytic 13 | 3,081
adult high grade glioma 13 | 3,801
invasive ductal carcinoma 13 | 2,951
malignant mesothelioma 13 | 3,232
Kidney cancer 12 | 2,613
interstitial cystitis 12 | 2,312
lung adenocarcinoma 12 | 2,716
Acquired scoliosis 11 | 281
Curvature of spine 11 | 282
Hypertensive disease 10 | 292
Short stature 10 | 531
breast carcinoma 10 | 1,638
lung carcinoma 10 | 2,843
oligodendroglioma 10 | 2,850
Increase in blood pressure 9 | 119
Osteoarthritis 9 | 184
cystic fibrosis 9 | 1,696
ductal carcinoma in situ 9 | 1,745
pancreatic cancer 9 | 2,398
Acquired flat foot 8 | 72
Cleft Palate 8 | 271
Craniofacial Abnormalities 8 | 151
Flatfoot 8 | 73
Liver Cirrhosis, Experimental 8 | 769
acute quadriplegic myopathy 8 | 1,158
astrocytic glioma 8 | 2,597
ulcerative colitis 8 | 1,819
Breast Neoplasms 7 | 445
Byzanthine arch palate 7 | 194
Congenital deafness 7 | 185
Cryptorchidism 7 | 296
Deafness 7 | 198
Hearing Loss, Partial 7 | 185
Hereditary hemorrhagic telangiectasia 7 | 13
Mammary Neoplasms 7 | 425
Orbital separation excessive 7 | 244
Pick disease 7 | 1,894
astrocytoma 7 | 1,146
diabetes mellitus 7 | 1,728
group 4 medulloblastoma 7 | 1,855
hearing impairment 7 | 199
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
juvenile dermatomyositis 7 | 1,187
non-small cell lung cancer 7 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pituitary cancer 7 | 1,972
primitive neuroectodermal tumor 7 | 3,035
Aortic Valve Insufficiency 6 | 40
Autosomal recessive predisposition 6 | 1,442
Bilateral fifth finger clinodactyly 6 | 110
Brachydactyly 6 | 156
Coronary artery disease 6 | 268
Curvature of little finger 6 | 110
Epilepsy 6 | 792
Exophthalmos 6 | 112
Fibrodysplasia ossificans progressiva 6 | 17
Hypoplastic mandible condyle 6 | 275
Loeys-Dietz syndrome 6 | 23
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Prominent eyes 6 | 96
Prominent globes 6 | 96
Protruding eyes 6 | 96
Pulmonary Fibrosis 6 | 106
Schizophrenia 6 | 1,160
Seizures 6 | 596
Ureteral obstruction 6 | 33
colon cancer 6 | 1,478
tuberculosis 6 | 2,010
Arachnodactyly 5 | 49
Chest Pain 5 | 38
Colorectal Neoplasms 5 | 243
Decreased joint mobility 5 | 53
Heart disease 5 | 306
Hernia, Inguinal 5 | 89
Hypertension 5 | 396
Hypotrophic malar bone 5 | 129
Kidney disease 5 | 430
Malar flattening 5 | 129
Multiple synostoses syndrome 5 | 9
Polycystic ovary syndrome 5 | 360
Prostatic Neoplasms 5 | 495
Retrognathia 5 | 54
Rheumatoid arthritis 5 | 1,191
Waldenstrons macroglobulinemia 5 | 765
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
pediatric high grade glioma 5 | 1,064
subependymal giant cell astrocytoma 5 | 2,287

Tissue

Endocrine System 51 | 18,159
Female tissues 51 | 17,400
Liver and Pancreas 50 | 16,750
Digestive Tract 48 | 17,369
Urinary Tract 48 | 16,678
Male tissues 47 | 17,142
Skin and soft tissues 47 | 17,230
Blood and immune system 46 | 16,909
Cardiovascular System 46 | 15,192
Nervous System 46 | 16,725
Respiratory system 46 | 16,393

Target Family

Non-IDG 30 | 12,091
Kinase 11 | 634
Transcription Factor 7 | 1,400
Epigenetic 3 | 242

PathwayCommons: inoh Pathway

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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Growth/differentiation factor 2 GDF2 Tbio Non-IDG -2.16825 176.4 239
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.65728 4647.9 684
Bone morphogenetic protein 3 BMP3 Tbio Non-IDG -2.11354 130.5 361
Bone morphogenetic protein 6 BMP6 Tbio Non-IDG -2.55269 373.2 317
Growth/differentiation factor 6 GDF6 Tbio Non-IDG -2.31035 205.4 110
Growth/differentiation factor 7 GDF7 Tbio Non-IDG -1.56725 40.0 180
Bone morphogenetic protein receptor type-1B BMPR1B Tchem Kinase -2.00303 86.8 498
Growth/differentiation factor 8 MSTN Tbio Non-IDG -3.08307 1338.8 568