Development Level

Tclin 4 | 612
Tchem 3 | 1,388
Tbio 1 | 11,651

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal coat appearance 1 | 31
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
cataract 1 | 92
decreased body weight 1 | 161
decreased total body fat amoun... 1 | 207

Disease

Carcinoma 7 | 11,493
Cancer 6 | 2,499
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Short stature 5 | 531
glioblastoma 5 | 5,792
ovarian cancer 5 | 8,520
Acquired scoliosis 4 | 281
Blepharoptosis 4 | 231
Byzanthine arch palate 4 | 194
Cardiomyopathy 4 | 116
Concave bridge of nose 4 | 195
Congenital Epicanthus 4 | 177
Cryptorchidism 4 | 296
Curvature of spine 4 | 282
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Downward slant of palpebral fissure 4 | 158
Dry skin 4 | 75
Dull intelligence 4 | 645
Feeding difficulties in infancy 4 | 175
High forehead 4 | 102
Hypertrophic Cardiomyopathy 4 | 117
Intellectual disability 4 | 1,016
Kidney Neoplasm 4 | 29
Kidney Neoplasms 4 | 37
LEOPARD syndrome 4 | 20
Low intelligence 4 | 645
Low posterior hairline 4 | 52
Low-set, posteriorly rotated ears 4 | 110
Lung Neoplasms 4 | 232
Malignant Melanoma with BRAF V600E Mutation 4 | 4
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Metastatic malignant melanoma 4 | 9
Multiple lentigines 4 | 10
Multiple myeloma 4 | 1,332
Muscle hypotonia 4 | 571
Neck webbing 4 | 35
Noonan syndrome 4 | 34
Orbital separation excessive 4 | 244
Pectus excavatum 4 | 100
Poor school performance 4 | 645
Premature Birth 4 | 77
Premature birth of newborn 4 | 67
Pulmonary Stenosis 4 | 45
Senile lentigo 4 | 10
Short neck 4 | 140
Skin hyperelastic 4 | 32
Strabismus 4 | 270
Tall forehead 4 | 102
Thickened helices 4 | 15
Xerosis 4 | 75
atypical teratoid / rhabdoid tumor 4 | 5,112
osteosarcoma 4 | 7,950
Abnormality of vision 3 | 40
Absence of eyebrows 3 | 31
Anteverted nostril 3 | 191
Aplasia/Hypoplasia of the eyebrow 3 | 31
Atrial Septal Defects 3 | 85
Big calvaria 3 | 147
Bleeding tendency 3 | 37
Brain Ischemia 3 | 110
Carcinoma of thyroid 3 | 17
Coarse facial features 3 | 108
Electroencephalogram abnormal 3 | 101
Failure to thrive in infancy 3 | 32
Fine hair 3 | 42
Frontal bossing 3 | 157
Hemangioma, Cavernous 3 | 20
Hyperalgesia 3 | 83
Hypoplasia of the zygomatic bone 3 | 22
Ichthyoses 3 | 41
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Large auricle 3 | 87
Large dysplastic ears 3 | 87
Large pinnae 3 | 87
Large prominent ears 3 | 87
Large protruding ears 3 | 87
Large, floppy ears 3 | 87
Liver cell carcinoma 3 | 15
Long philtrum 3 | 137
Lymphangioma, Cystic 3 | 21
Macrotia 3 | 87
Melanoma 3 | 711
Myopia 3 | 176
Palmoplantar keratosis 3 | 74
Renal Cell Carcinoma 3 | 214
Short nose 3 | 132
Sparse hair 3 | 59
Sparse or absent eyebrows 3 | 31
Sparse/absent eyebrows 3 | 31
Thickened facial skin with coarse facial features 3 | 108
Thin, sparse hair 3 | 59
Triangular face 3 | 58
Underdeveloped brows 3 | 38
Underdeveloped supraorbital ridges 3 | 38

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Kinase 7 | 634
Transcription Factor 1 | 1,400

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 8 | 8
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.33582 220.9 1431
Dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 Tclin Kinase -1.83744 60.9 883
Serine/threonine-protein kinase A-Raf ARAF Tchem Kinase -2.46615 277.6 465
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
RAF proto-oncogene serine/threonine-protein kinase RAF1 Tclin Kinase -3.11577 1210.8 2254