Development Level

Tbio 29 | 11,445
Tchem 18 | 1,598
Tclin 8 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 4 | 499
decreased mean platelet volume 3 | 25
short tibia 3 | 97
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
enlarged spleen 2 | 41
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
abnormal behavior 1 | 298
abnormal heart morphology 1 | 162
abnormal locomotor behavior 1 | 24
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged thymus 1 | 5
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 24
increased fasted circulating g... 1 | 76
increased glycosylated hemoglo... 1 | 1
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
male infertility 1 | 123
prenatal lethality 1 | 28
thrombocytopenia 1 | 56

Disease

Carcinoma 38 | 11,493
ovarian cancer 33 | 8,520
medulloblastoma, large-cell 31 | 6,241
glioblastoma 30 | 5,792
atypical teratoid / rhabdoid tumor 29 | 5,112
osteosarcoma 28 | 7,950
Cancer 27 | 2,499
psoriasis 25 | 6,694
ependymoma 22 | 4,679
Breast cancer 20 | 3,578
lung cancer 20 | 4,740
adult high grade glioma 19 | 3,801
astrocytic glioma 17 | 2,597
Kidney cancer 16 | 2,613
group 4 medulloblastoma 15 | 1,855
oligodendroglioma 15 | 2,850
Orbital separation excessive 13 | 244
group 3 medulloblastoma 13 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
primitive neuroectodermal tumor 13 | 3,035
subependymal giant cell astrocytoma 13 | 2,287
Cognitive delay 12 | 608
Epilepsy 12 | 792
Global developmental delay 12 | 608
Mental and motor retardation 12 | 608
Downward slant of palpebral fissure 11 | 158
Schizophrenia 11 | 1,160
Seizures 11 | 596
diabetes mellitus 11 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
malignant mesothelioma 11 | 3,232
pancreatic cancer 11 | 2,398
Astrocytoma, Pilocytic 10 | 3,081
Muscle hypotonia 10 | 571
Pick disease 10 | 1,894
juvenile dermatomyositis 10 | 1,187
lung adenocarcinoma 10 | 2,716
Bipolar Disorder 9 | 666
Blepharoptosis 9 | 231
Byzanthine arch palate 9 | 194
Delayed bone age 9 | 136
High forehead 9 | 102
Hypoplastic mandible condyle 9 | 275
Intellectual disability 9 | 1,016
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Multiple myeloma 9 | 1,332
Renal Cell Carcinoma 9 | 214
Rheumatoid arthritis 9 | 1,191
Stomach Neoplasms 9 | 300
Tall forehead 9 | 102
breast carcinoma 9 | 1,638
dermatomyositis 9 | 966
interstitial cystitis 9 | 2,312
invasive ductal carcinoma 9 | 2,951
Alzheimer's disease 8 | 658
Carcinoma, Hepatocellular 8 | 228
Concave bridge of nose 8 | 195
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Dull intelligence 8 | 645
Excess nuchal skin 8 | 30
Frontal bossing 8 | 157
Full lower lip 8 | 64
Insulin Resistance 8 | 72
Joint hyperflexibility 8 | 78
Liver carcinoma 8 | 240
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Pectus excavatum 8 | 100
Poor school performance 8 | 645
Prominent lower lip 8 | 64
Short stature 8 | 531
Strabismus 8 | 270
primary pancreatic ductal adenocarcinoma 8 | 1,109
tuberculosis 8 | 2,010
Acquired scoliosis 7 | 281
Autosomal recessive predisposition 7 | 1,442
Big calvaria 7 | 147
Cardiac Arrhythmia 7 | 103
Conduction disorder of the heart 7 | 79
Congenital Epicanthus 7 | 177
Curvature of spine 7 | 282
Dysarthria 7 | 192
Electrocardiogram abnormal 7 | 81
Endometrial cancer 7 | 311
Exophthalmos 7 | 112
Feeding difficulties in infancy 7 | 175
Increased head circumference 7 | 147
Increased size of cranium 7 | 147
Increased size of skull 7 | 147
Low-set, posteriorly rotated ears 7 | 110
Prominent eyes 7 | 96
Prominent globes 7 | 96
Protruding eyes 7 | 96
Short neck 7 | 140
Triangular face 7 | 58
ductal carcinoma in situ 7 | 1,745

Tissue

Digestive Tract 55 | 17,369
Endocrine System 55 | 18,159
Female tissues 55 | 17,400
Skin and soft tissues 55 | 17,230
Cardiovascular System 54 | 15,192
Male tissues 54 | 17,142
Nervous System 54 | 16,725
Blood and immune system 53 | 16,909
Liver and Pancreas 53 | 16,750
Respiratory system 53 | 16,393
Urinary Tract 53 | 16,678

Target Family

Enzyme 20 | 4,145
Non-IDG 20 | 12,091
Kinase 14 | 634
Transporter 1 | 473

PathwayCommons: inoh Pathway

http://pathwaycommons.org/pc2/... 55 | 55
http://pathwaycommons.org/pc2/... 236 | 236
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This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113
14-3-3 protein gamma YWHAG Tbio Non-IDG -1.87443 78.9 387
SHC-transforming protein 3 SHC3 Tbio Non-IDG -1.97665 99.4 137
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134
Insulin receptor substrate 4 IRS4 Tbio Non-IDG -1.60429 0.00000 121